Magnetization Losses in Multifilament Coated Superconductors

We report the results of a study of the magnetization losses in experimental multifilament, as well as control (uniform), coated superconductors exposed to time-varying magnetic field of various frequencies. Both the hysteresis loss, proportional to the sweep rate of the applied magnetic field, and the coupling loss, proportional to the square of the sweep rate, have been observed. A scaling is found that allows us to quantify each of these contributions and extrapolate the results of the experiment beyond the envelope of accessible field amplitude and frequency. The combined loss in the multifilament conductor is reduced by about 90% in comparison with the uniform conductor at full field penetration at sweep rate as high as 3T/s

Accelerometers can measure total and activity-specific energy expenditures in free-ranging marine mammals only if linked to time-activity budgets

Peer reviewedPostprin

Nonadditivity of convoy- and secondary-electron yields in the forward-electron emission from thin carbon foils under irradiation of fast carbon-cluster ions

We have measured energy spectra of secondary electrons produced by fast-carbon-cluster Cn+ (n=1–4) bombardment of thin carbon foils (3.2, 7.3, 11.9, and 20.3 µg/cm2). For clusters of identical velocity, the convoy-electron yield is enhanced with increasing cluster size n, while the yield of secondary electrons is reduced. The yield of convoy electrons normalized to the number of injected atoms increases proportionally with cluster size n. This proportionality suggests that there is only a weak vicinage effect on the number of primary electrons scattered by the projectile. The vicinage effect observed in low-energy secondary electrons must therefore arise from either transport or transmission through the surface

Interaction induced collapse of a section of the Fermi sea in in the zig-zag Hubbard ladder

Using the next-nearest neighbor (zig-zag) Hubbard chain as an one dimemensional model, we investigate the influence of interactions on the position of the Fermi wavevectors with the density-matrix renormalization-group technique (DMRG). For suitable choices of the hopping parameters we observe that electron-electron correlations induce very different renormalizations for the two different Fermi wavevectors, which ultimately lead to a complete destruction of one section of the Fermi sea in a quantum critical point

Secondary-Structure Design of Proteins by a Backbone Torsion Energy

We propose a new backbone-torsion-energy term in the force field for protein systems. This torsion-energy term is represented by a double Fourier series in two variables, the backbone dihedral angles phi and psi. It gives a natural representation of the torsion energy in the Ramachandran space in the sense that any two-dimensional energy surface periodic in both phi and psi can be expanded by the double Fourier series. We can then easily control secondary-structure-forming tendencies by modifying the torsion-energy surface. For instance, we can increase/decrease the alpha-helix-forming-tendencies by lowering/raising the torsion-energy surface in the alpha-helix region and likewise increase/decrease the beta-sheet-forming tendencies by lowering/raising the surface in the beta-sheet region in the Ramachandran space. We applied our approach to AMBER parm94 and AMBER parm96 force fields and demonstrated that our modifications of the torsion-energy terms resulted in the expected changes of secondary-structure-forming-tendencies by performing folding simulations of alpha-helical and beta-hairpin peptides.Comment: 13 pages, (Revtex4), 5 figure

Differential Regulation of the Melanoma Proteome by eIF4A1 and eIF4E.

Small molecules and antisense oligonucleotides that inhibit the translation initiation factors eIF4A1 and eIF4E have been explored as broad-based therapeutic agents for cancer treatment, based on the frequent upregulation of these two subunits of the eIF4F cap-binding complex in many cancer cells. Here, we provide support for these therapeutic approaches with mechanistic studies of eIF4F-driven tumor progression in a preclinical model of melanoma. Silencing eIF4A1 or eIF4E decreases melanoma proliferation and invasion. There were common effects on the level of cell-cycle proteins that could explain the antiproliferative effects in vitro Using clinical specimens, we correlate the common cell-cycle targets of eIF4A1 and eIF4E with patient survival. Finally, comparative proteomic and transcriptomic analyses reveal extensive mechanistic divergence in response to eIF4A1 or eIF4E silencing. Current models indicate that eIF4A1 and eIF4E function together through the 5'UTR to increase translation of oncogenes. In contrast, our data demonstrate that the common effects of eIF4A1 and eIF4E on translation are mediated by the coding region and 3'UTR. Moreover, their divergent effects occur through the 5'UTR. Overall, our work shows that it will be important to evaluate subunit-specific inhibitors of eIF4F in different disease contexts to fully understand their anticancer actions. Cancer Res; 77(3); 613-22. ©2016 AACR