Roles for RAB24 in autophagy and disease

Autophagy is an evolutionarily conserved degradation pathway for cells to maintain homeostasis, produce energy, degrade misfolded proteins and damaged organelles, and fight against intracellular pathogens. The process of autophagy entails the isolation of cytoplasmic cargo into double membrane bound autophagosomes that undergo maturation by fusion with endosomes and lysosomes to obtain degradation capacity. RAB proteins regulate intracellular vesicle trafficking events including autophagy. RAB24 is an atypical RAB protein that is required for the clearance of late autophagic vacuoles under basal conditions. RAB24 has also been connected to several diseases including ataxia, cancer and tuberculosis. This review gives a short summary on autophagy and RAB proteins, and an overview on the current knowledge on the roles of RAB24 in autophagy and disease.</p

Climate Policy Networks in Australia: Dynamics of Failure and Possibility

Many high-income countries are committed to effective climate policy, yet remain heavily dependent on fossil fuel extraction. The contradiction between an intensifying climate crisis and continued policy failure generates new political alignments, constituencies, and agendas. A dialectical process of socio-ecological change opens-up, where the climate is "socialised" and society is "climatised". Australia is a high-income, high-emitting fossil fuel "superpower" with a thirty-year stretch of failing climate policy, and offers an exceptionally vivid illustration of this dynamic. The paper explores these themes through the rhetoric of participants in Australian climate policy networks. It is based on sustained involvement the field and a series of in-depth interviews with organisations that seek to influence Australian climate policy, across business associations, trade unions, environmental non-governmental organisations, government agencies, and think tanks. It finds extensive strategic reflection across these organisations, with moves to more collaboration and alliance-building to isolate the fossil fuel lobby, and efforts at creating new constituencies to advance decarbonisation "on the ground".Peer reviewe

Economic and Industrial Policy Transformations in Finland

Finland, economic transformation, industrial policies, innovation system, O33, O38, O52, O57, L52, L53,

Assassins

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