Gender framing in political advertising during the 2014 United States senate election in North Carolina, Louisiana, Iowa and Kentucky

There is an increasing tendency for political candidates to frame their campaign advertising more negatively when mentioning their opponents rather than talk positively about themselves. However, some gender differences are likely to influence the amount of negative content in one\u27s advertising. In addition, gender stereotypes are considered as a disadvantage factor for women in campaigns, while some scholars suggest that stereotypes might help to build the reputation of women. As a result, this study examined the 2014 election for U.S. senate in North Carolina, Iowa, Kentucky and Louisiana because these four states were rated as top four states in terms of spending on negative political ads that included a woman and a man candidate (Chris, 2014). Content analysis is used to examine differences in stimuli used in the negative political ads in the 2014 midterm race for U.S. senate. This comparative analysis reveals more similarities than differences between the two gender groups in terms of framing, and male candidate ads (and especially ads sponsored by Super PACs for male candidates) were found to be more negative than female candidate ads

Inhibition of miR-665 alleviates lipopolysaccharide-induced inflammation via up-regulation of SOCS7 in chondrogenic ATDC5 cells

Purpose: To examine the effect and mechanism of action of miR-665 in osteoarthritis.Methods: An in vitro inflammatory injury model of osteoarthritis was established using chondrogenic ATDC5 cells with lipopolysaccharide (LPS) treatment. The expression levels of inflammatory cytokines were determined by enzyme-linked immunosorbent assays (ELISAs) and by quantitative real-time polymerase chain reaction (qRT-PCR). A binding target for miR-665 was predicted using TargetScan and then evaluated using a dual-luciferase reporter assay.Results: Treatment with LPS significantly up-regulated the inflammatory cytokine expressions of interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-alpha (TNF-α), in ATDC5 cells (p < 0.01), and the expression of miRNA-665 was significantly increased in LPS-treated ATDC5 cells (p < 0.01).Knockdown of miR-665 down-regulated the expression levels of these inflammatory cytokines. Suppressor of cytokine signaling 7 (SOCS7) was identified as a target of miR-665. Data from qRT-PCR and western-blot analyses indicated that SOCS7 expression was promoted by miR-665  inhibition and inhibited by miR-665 over-expression. LPS treatment significantly decreased the expression of SOCS7 protein in ATDC5 cells (p < 0.01), and over-expression of SOCS7 attenuated the LPS-stimulated inflammatory injury. In addition, over-expression of miR-655 enhanced the inflammatory injury and reversed the protective effect of SOCS7 against LPS-stimulated inflammation.Conclusion: Inhibition of miR-665 alleviated LPS-stimulated inflammatory injury in ATDC5 cells via the up-regulation of SOCS7, suggesting a potential therapeutic target for osteoarthritis. Keywords: MiR-665, Lipopolysaccharide, Inflammation, SOCS7, Chondrogenic, ATDC

Effects of Aromatic Ammoniums on Methyl Ammonium Lead Iodide Hybrid Perovskite Materials

The introduction of bulky ammoniums into methyl ammonium lead iodide hybrid perovskites (MAPbI3) has emerged as a promising strategy to improve the properties of these materials. In the present work, we studied the effects of several aromatic ammoniums onto the structural, electronic, and optical properties of MAPbI3. Although powder XRD data suggest that the bulky cations are not involved in the bulk phase of the MAPbI3, a surprisingly large effect of the bulky cations onto the photoluminescence properties was observed

Learning to Check Contract Inconsistencies

Contract consistency is important in ensuring the legal validity of the contract. In many scenarios, a contract is written by filling the blanks in a precompiled form. Due to carelessness, two blanks that should be filled with the same (or different)content may be incorrectly filled with different (or same) content. This will result in the issue of contract inconsistencies, which may severely impair the legal validity of the contract. Traditional methods to address this issue mainly rely on manual contract review, which is labor-intensive and costly. In this work, we formulate a novel Contract Inconsistency Checking (CIC) problem, and design an end-to-end framework, called Pair-wise Blank Resolution (PBR), to solve the CIC problem with high accuracy. Our PBR model contains a novel BlankCoder to address the challenge of modeling meaningless blanks. BlankCoder adopts a two-stage attention mechanism that adequately associates a meaningless blank with its relevant descriptions while avoiding the incorporation of irrelevant context words. Experiments conducted on real-world datasets show the promising performance of our method with a balanced accuracy of 94.05% and an F1 score of 90.90% in the CIC problem.Comment: Accepted by AAAI 202

3-O-Caffeoylquinic acid in Periploca forrestii Schltr extract ameliorates collagen-induced arthritis by inducing IL17/IL23 cells in rats

Purpose: To study the therapeutic effect of 3-O-caffeoylquinic acid (3-O-CQA) from Periploca forrestii extract (PFE) on collagen-mediated arthritis (CIA) in rats, as well as the potential underlying mechanism of action. Methods: PFE and 3-O-CQA were successively and intragastrically administered to CIA rats. Paw swelling, arthritic scores and H & E staining were used to evaluate the therapeutic effect of 3-O-CQA. Moreover, to determine the effects of PFE and 3-O-CQA on fibroblast-resembling synoviocytes obtained from arthritic subjects (RAFLS), the viability of RAFLS cultured in vitro was measured with MMT, while apoptotic lesions were analyzed by flow cytometry. The levels of IL-6 in CIA and RAFLS were determined by enzyme-linked immunosorbent assay (ELISA), while quantitative reverse transcriptionpolymerase chain reaction (qRT-PCR) and immunoblotting were used to assess their mRNA and polypeptide levels, respectively. Results: PFE in 3-O-CQA ameliorated swelling and reduced arthritic scores in CIA rat model, and also decreased cytokine levels (p < 0.05). By decreasing mRNA and protein expressions, 3-O-CQA repressed the phosphorylation of STAT3 and JAK2 as well as the protein levels of IL-23 and RORγt (p < 0.05). Conclusion: The results of this study show that CIA and RAFLS are ameliorated in rats by 3-O-CQA in PFE through regulation of IL17/ IL23 and Th17 cells. Thus, 3-O-CQA affords a therapeutic strategy for the management of collagen-induced arthritis. Keywords: Arthriti; Periploca forrestii Schltr extract; 3-O-Caffeoylquinic acid; Interleukin (IL)-17; IL-23; Th17 cell

Diesel degradation capability and environmental robustness of strain Pseudomonas aeruginosa WS02

Petroleum hydrocarbon (PHC) degrading bacteria have been frequently discovered. However, in practical application, a single species of PHC degrading bacterium with weak competitiveness may face environmental pressure and competitive exclusion due to the interspecific competition between petroleum-degrading bacteria as well as indigenous microbiota in soil, leading to a reduced efficacy or even malfunction. In this study, the diesel degradation ability and environmental robustness of an endophytic strain Pseudomonas aeruginosa WS02, were investigated. The results show that the cell membrane surface of WS02 was highly hydrophobic, and the strain secreted glycolipid surfactants. Genetic analysis results revealed that WS02 contained multiple metabolic systems and PHC degradation-related genes, indicating that this strain theoretically possesses the capability of oxidizing both alkanes and aromatic hydrocarbons. Gene annotation also showed many targets which coded for heavy metal resistant and metal transporter proteins. The gene annotation-based inference was confirmed by the experimental results: GC-MS analysis revealed that short chain PHCs (C10–C14) were completely degraded, and the degradation of PHCs ranging from C15–C22 were above 90% after 14 d in diesel-exposed culture; Heavy metal (Mn2+, Pb2+ and Zn2+) exposure was found to affect the growth of WS02 to some extent, but not its ability to degrade diesel, and the degradation efficiency was still maintained at 39–59%. WS02 also showed a environmental robustness along with PHC-degradation performance in the co-culture system with other bacterial strains as well as in the co-cultured system with the indigenous microbiota in soil fluid extracted from a PHC-contaminated site. It can be concluded that the broad-spectrum diesel degradation efficacy and great environmental robustness give P. aeruginosa WS02 great potential for application in the remediation of PHC-contaminated soil.<br/

Automatic Insertion of Hot Keywords to Drive Traffic on Advertisements

Product titles and descriptions that include appropriate keywords, when used in an online advertisement, can improve the shopping feed quality and resultant traffic to the advertiser. However, online merchants lack knowledge of currently trending or popular keywords, and lacking keyword ideation, may choose suboptimal product titles. This disclosure describes techniques that enable online merchants to automatically optimize product titles or descriptions, e.g., as used in online ads. Trending or popular keywords relevant to the product are automatically added to the product title or description. Unique, product-specific insights gleaned from searched terms are utilized to improve title effectiveness automatically and at scale