Properties of nuclear matter from macroscopic-microscopic mass formulas

Based on the standard Skyrme energy density functionals together with the extended Thomas-Fermi approach, the properties of symmetric and asymmetric nuclear matter represented in two macroscopic-microscopic mass formulas: Lublin-Strasbourg nuclear drop energy (LSD) formula and Weizs\"acker-Skyrme (WS*) formula, are extracted through matching the energy per particle of finite nuclei. For LSD and WS*, the obtained incompressibility coefficients of symmetric nuclear matter are $K_\infty=230 \pm 11$ MeV and $235\pm 11$ MeV, respectively. The slope parameter of symmetry energy at saturation density is $L=41.6\pm 7.6$ MeV for LSD and $51.5\pm 9.6$ MeV for WS*, respectively, which is compatible with the liquid-drop analysis of Lattimer and Lim [ApJ. \textbf{771}, 51 (2013)]. The density dependence of the mean-field isoscalar and isovector effective mass, and the neutron-proton effective masses splitting for neutron matter are simultaneously investigated. The results are generally consistent with those from the Skyrme Hartree-Fock-Bogoliubov calculations and nucleon optical potentials, and the standard deviations are large and increase rapidly with density. A better constraint for the effective mass is helpful to reduce uncertainties of the depth of the mean-field potential.Comment: 5 figures, to appear in Phys. Lett.

Further Development of the Improved QMD Model and its Applications to Fusion Reaction near Barrier

The Improved Quantum Molecular Dynamics model is further developed by introducing new parameters in interaction potential energy functional based on Skyrme interaction of SkM$^{*}$ and SLy series. The properties of ground states of selected nuclei can be reproduced very well. The Coulomb barriers for a series of reaction systems are studied and compared with the results of the proximity potential. The fusion excitation functions for a series of fusion reactions are calculated and the results are in good agreement with experimental data.Comment: 17 pages, 10 figures, PRC accepte

Constraints on symmetry energy and nucleon effective mass splitting with Heavy Ion Collisions

A new version of the improved quantum molecular dynamics model has been developed to include standard Skyrme interactions. Four commonly used Skyrme parameter sets, SLy4, SkI2, SkM* and Gs are adopted in the transport model code to calculate the isospin diffusion observables as well as single and double ratios of transverse emitted nucleons. While isospin diffusion observables are sensitive to the symmetry energy term, they are not very sensitive to the nucleon effective mass splitting parameters in the interactions. Our calculations show that the high energy neutrons and protons and their ratios from reactions at different incident energies provide a robust observable to study the momentum dependence of the nucleon effective mass splitting. However the sensitivity of effective mass splitting effect on the n/p yield ratios decreases with increasing beam energy, even though high energy proton and neutron are produced more abundantly at high beam energy. Our calculations show that the optimum incident energy to study nucleon effective masses is between 100-200 MeV per nucleon.Comment: Submitted to PLB, 14 pages, 4 figure

Manufacture of IRDye800CW-coupled Fe3O4 nanoparticles and their applications in cell labeling and in vivo imaging

BackgroundIn recent years, near-infrared fluorescence (NIRF)-labeled iron nanoparticles have been synthesized and applied in a number of applications, including the labeling of human cells for monitoring the engraftment process, imaging tumors, sensoring the in vivo molecular environment surrounding nanoparticles and tracing their in vivo biodistribution. These studies demonstrate that NIRF-labeled iron nanoparticles provide an efficient probe for cell labeling. Furthermore, the in vivo imaging studies show excellent performance of the NIR fluorophores. However, there is a limited selection of NIRF-labeled iron nanoparticles with an optimal wavelength for imaging around 800 nm, where tissue autofluorescence is minimal. Therefore, it is necessary to develop additional alternative NIRF-labeled iron nanoparticles for application in this area.ResultsThis study manufactured 12-nm DMSA-coated Fe3O4 nanoparticles labeled with a near-infrared fluorophore, IRDye800CW (excitation/emission, 774/789 nm), to investigate their applicability in cell labeling and in vivo imaging. The mouse macrophage RAW264.7 was labeled with IRDye800CW-labeled Fe3O4 nanoparticles at concentrations of 20, 30, 40, 50, 60, 80 and 100 μg/ml for 24 h. The results revealed that the cells were efficiently labeled by the nanoparticles, without any significant effect on cell viability. The nanoparticles were injected into the mouse via the tail vein, at dosages of 2 or 5 mg/kg body weight, and the mouse was discontinuously imaged for 24 h. The results demonstrated that the nanoparticles gradually accumulated in liver and kidney regions following injection, reaching maximum concentrations at 6 h post-injection, following which they were gradually removed from these regions. After tracing the nanoparticles throughout the body it was revealed that they mainly distributed in three organs, the liver, spleen and kidney. Real-time live-body imaging effectively reported the dynamic process of the biodistribution and clearance of the nanoparticles in vivo.ConclusionIRDye800CW-labeled Fe3O4 nanoparticles provide an effective probe for cell-labeling and in vivo imaging

The Influence of in-medium NN cross-sections, symmetry potential and impact parameter on the isospin observables

We explore the influence of in-medium nucleon-nucleon cross section, symmetry potential and impact parameter on isospin sensitive observables in intermediate-energy heavy-ion collisions with the ImQMD05 code, a modified version of Quantum Molecular Dynamics model. At incident velocities above the Fermi velocity, we find that the density dependence of symmetry potential plays a more important role on the double neutron to proton ratio $DR(n/p)$ and the isospin transport ratio $R_i$ than the in-medium nucleon-nucleon cross sections, provided that the latter are constrained to a fixed total NN collision rate. We also explore both $DR(n/p)$ and $R_i$ as a function of the impact parameter. Since the copious production of intermediate mass fragments is a distinguishing feature of intermediate-energy heavy-ion collisions, we examine the isospin transport ratios constructed from different groups of fragments. We find that the values of the isospin transport ratios for projectile rapidity fragments with $Z\ge20$ are greater than those constructed from the entire projectile rapidity source. We believe experimental investigations of this phenomenon can be performed. These may provide significant tests of fragmentation time scales predicted by ImQMD calculations.Comment: 24 pages, 9 figures, to be published in Phys. Rev.

Altered expression of glycan patterns and glycan-related genes in the medial prefrontal cortex of the valproic acid rat model of autism

Autism spectrum disorders (ASD) represent a group of neurodevelopmental defects characterized by social deficits and repetitive behaviors. Alteration in Glycosylation patterns could influence the nervous system development and contribute to the molecular mechanism of ASD. Interaction of environmental factors with susceptible genes may affect expressions of glycosylation-related genes and thus result in abnormal glycosylation patterns. Here, we used an environmental factor-induced model of autism by a single intraperitoneal injection of 400 mg/kg valproic acid (VPA) to female rats at day 12.5 post-conception. Following confirmation of reduced sociability and increased self-grooming behaviors in VPA-treated offspring, we analyzed the alterations in the expression profile of glycan patterns and glycan-related genes by lectin microarrays and RNA-seq, respectively. Lectin microarrays detected 14 significantly regulated lectins in VPA rats, with an up-regulation of high-mannose with antennary and down-regulation of Siaα2-3 Gal/GalNAc. Based on the KEGG and CAZy resources, we assembled a comprehensive list of 961 glycan-related genes to focus our analysis on specific genes. Of those, transcription results revealed that there were 107 differentially expressed glycan-related genes (DEGGs) after VPA treatment. Functional analysis of DEGGs encoding anabolic enzymes revealed that the process trimming to form core structure and glycan extension from core structure primarily changed, which is consistent with the changes in glycan patterns. In addition, the DEGGs encoding glycoconjugates were mainly related to extracellular matrix and axon guidance. This study provides insights into the underlying molecular mechanism of aberrant glycosylation after prenatal VPA exposure, which may serve as potential biomarkers for the autism diagnosis

Effect of splitting of the neutron and proton effective mass on nuclear symmetry energy at finite temperature

We present the temperature and density dependence of symmetry energy for nuclear matter at finite temperature based on the approach of the thermodynamics with Skyrme energy density functional. We first classify the Skyrme interactions into 7 groups according to the range of neutron and proton effective mass in neutron matter limit(99.99 per cent neutron in the matter). We find that there is obvious correlation between the temperature dependence of the symmetry energy and the splitting of the neutron and proton effective mass. For some Skyrme interactions with $m^{*}_{n}>m^{*}_{p}$ and strong splitting of the neutron and proton effective mass in asymmetric nuclear matter, a transition of the temperature dependence of symmetry energy from decreasing with temperature at low densities to increasing with temperature at high densities appears. For other Skyrme interactions, we do not observe such phenomenon. Our study show that the symmetry energy in hot asymmetric matter not only depends on symmetry potential part but also on the splitting of the neutron and proton effective mass to a certain extent.Comment: 5 pages, 3 figures, accepted for Phys. Lett.