Advances in Single Nucleotide Polymorphisms of Vitamin D Metabolic Pathway Genes and Respiratory Diseases

Vitamin D is a fat-soluble vitamin. It is an essential vitamin for human body. It has a classical effect on regulating calcium and phosphorus metabolism. Participate in cellular and humoral immune processes by regulating the growth, differentiation and metabolism of immune cells. A large number of studies in recent years have shown that vitamin D deficiency increases the incidence of respiratory diseases. Respiratory diseases mainly include bronchial asthma, chronic obstructive pulmonary disease, tuberculosis, acute upper respiratory tract infection and pneumonia. Vitamin D metabolic pathway genes play a very important regulatory role in the transformation of vitamin D into active vitamin D, including CYP2R1,,CYP27B1, CYP24A1, VDBP, VDR five genes. Genetic polymorphism of genes is the molecular basis of individual differences and disease development. Therefore, this paper summarizes the research on single nucleotide polymorphism of vitamin D metabolic pathway gene and respiratory diseases. In order to provide a new idea for future treatment

Research Progress of Vitamin D and Pathogenesis of Bronchial Asthma

At present the incidence of bronchial asthma on the rise, its pathogenesis and the genetic immune and the relationship between social environment and other aspects are inseparable the activity of vitamin D (Vit D) in the body in the form of 1, 25 - (OH) 2 d3, mainly involved in bone metabolism and calcium absorption in addition to this, a growing number of studies show that in Vit D plays an important role in the pathogenesis of bronchial asthma, play a role in the immune function of bronchial asthma growth hormone sensitivity adjustment and airway remodeling in this paper, the development of a variety of mechanisms, such as Vit D. Review the possible mechanisms affecting bronchial asthma, hoping to provide adjuvant treatment for patients with bronchial asthma, discover new treatment approaches, and improve the quality of life for patients

Childhood trauma and suicide risk in hospitalized patients with schizophrenia: the sequential mediating roles of pandemic related post-traumatic stress symptoms, sleep quality, and psychological distress

IntroductionStressful global situation due to the COVID-19 pandemic caused a tremendous impact on mental health in hospitalized patients with schizophrenia. The mediating roles of psychological impact related to COVID-19, sleep quality, and psychological distress were investigated in the association between childhood trauma and suicidal risk in hospitalized patients with schizophrenia.MethodsWe analyzed cross-sectional data of 147 patients with schizophrenia and 189 healthy controls (HCs).ResultsHistories of childhood trauma and schizophrenia were good predictors of COVID-19-related psychological impact, global sleep quality, and psychological distress. Moreover, the series mediation model showed that the effect of childhood trauma on suicidal risk in hospitalized patients with schizophrenia was totally sequential mediated by the psychological impact of COVID-19, sleep quality, and psychological distress.ConclusionClinicians need to recognize the increased suicidal risk associated with COVID-19-related psychological distress in schizophrenia patients with a history of childhood trauma

A Journey into the City. Migrant Workers' Relation with the Urban Space and Struggle for Existence in Xu Zechen's Early Jingpiao Fiction

In contemporary China, rural-urban migrants constitute a new urban subject with entirely new identity-related issues. This study aims at demonstrating how literature can be a valid field in investigating such evolving subjectivities, through an analysis of Xu Zechen’s early novellas depicting migrants’ vicissitudes in Beijing. Combining a close reading of the texts and a review of the main social problems characterising rural-urban migration in China, this paper focuses on the representation of the identity crisis within the migrant self in Xu’s stories, taking into account the network of meanings employed by the writer to signify the objective and subjective tension between the city and the countryside

Achieving differentiated quality of service and high revenue through scheduling on E-commerce systems

As competition among e-commerce websites continue to escalate the need for using appropriate system management strategies that improve the revenue of the website is becoming increasingly important. One way of improving revenue is to encourage heavy buyers by providing them with a higher quality of service in comparison to customers that are less likely to buy an item from the store. This paper focuses on effective scheduling strategies that provide differentiated service to three classes of customers. The main objective of the research is to achieve a high revenue generated by a website and support its business goal, while providing higher responsiveness for the higher priority customer classes. A number of scheduling policies that use varying degrees of knowledge of system and customer characteristics is proposed and their performances are analyzed through a performance prototype. The experimental results lead to a number of insights underlying system performance and the revenue earned for the online stores

Square one: zygote polarity and early embryogenesis in flowering plants

In the last two decades, work on auxin signaling has helped to understand many aspects of the fundamental process underlying the specification of tissue types in the plant embryo. However, the immediate steps after fertilization including the polarization of the zygote and the initial body axis formation remained poorly understood. Valuable insight into these enigmatic processes has been gained by studying fertilization in grasses. Recent technical advances in transcriptomics of developing embryos with high spatial and temporal resolution give an emerging picture of the rapid changes of the zygotic developmental program. Together with the use of live imaging of novel fluorescent marker lines, these data are now the basis of unraveling the very first steps of the embryonic patterning process

Identification of potential immunotherapeutic targets and prognostic biomarkers in Graves' disease using weighted gene co-expression network analysis

Graves' disease (GD) is an autoimmune disorder characterized by hyperthyroidism resulting from autoantibody-induced stimulation of the thyroid gland. Despite recent advancements in understanding GD's pathogenesis, the molecular processes driving disease progression and treatment response remain poorly understood. In this study, we aimed to identify crucial immunogenic factors associated with GD prognosis and immunotherapeutic response. To achieve this, we implemented a comprehensive screening strategy that combined computational immunogenicity-potential scoring with multi-parametric cluster analysis to assess the immunomodulatory genes in GD-related subtypes involving stromal and immune cells. Utilizing weighted gene co-expression network analysis (WGCNA), we identified co-expressed gene modules linked to cellular senescence and immune infiltration in CD4+ and CD8+ GD samples. Additionally, gene set enrichment analysis enabled the identification of hallmark pathways distinguishing high- and low-immune subtypes. Our WGCNA analysis revealed 21 gene co-expression modules comprising 1,541 genes associated with immune infiltration components in various stages of GD, including T cells, M1 and M2 macrophages, NK cells, and Tregs. These genes primarily participated in T cell proliferation through purinergic signaling pathways, particularly neuroactive ligand-receptor interactions, and DNA binding transcription factor activity. Three genes, namely PRSS1, HCRTR1, and P2RY4, exhibited robustness in GD patients across multiple stages and were involved in immune cell infiltration during the late stage of GD (p < 0.05). Importantly, HCRTR1 and P2RY4 emerged as potential prognostic signatures for predicting overall survival in high-immunocore GD patients (p < 0.05). Overall, our study provides novel insights into the molecular mechanisms driving GD progression and highlights potential key immunogens for further investigation. These findings underscore the significance of immune infiltration-related cellular senescence in GD therapy and present promising targets for the development of new immunotherapeutic strategies

Tunable control of subwavelength topological interface modes in locally resonance piezoelectric metamaterials

This paper reports the evidence of the tunable sub-wavelength topological interface state in local resonance piezoelectric metamaterials. An elastic beam serves as the host medium with periodically arranged local resonators and attached piezoelectric layers. Thus, the shunt circuits connected with the piezoelectric layers can easily change the electromechanical stiffness in any unit cell. By inspired the band-folding mechanism, doubling the primitive unit cell generates two Dirac points, whose one lower point falls below the locally resonant bandgap and is in the sub-wavelength region. Then, employing the shunt circuit's tunability opens band-folding points to develop two bandgaps associated with the Bragg scattering effect. Band inversion and topological transition exist during the negative capacitance parameter variation. Numerical simulations demonstrate interface wave propagation for excitation at the interface frequency in the heterostructure, composted of two media with different topological invariants. With the assistance of the piezoelectric shunting circuit, our proposed design can induce wave localization over multiple frequency bands, which has potential for applications such as signal filters, energy harvesting and vibration isolation. Finally, we investigate the relationship between the interface frequency and capacitance and consider the local resonance effect on topological interface modes