Fixation Probabilities on Complete Star and Bipartite Digraphs

This paper exactly formulates the kth-order fixation probabilities on complete star digraphs (CSDs), which extend the results from Broom and Rychtář (2008). By applying these probability formulae, some asymptotic properties on CBDs are analyzed, and certain CSDs are determined to be amplifiers of selection for arbitrary relative fitness larger than 1, while all the CSDs are proved to be amplifiers of selection for fixed relative fitness slightly larger than 1. A numerical method for fixed population structure (by solving a linear system) is developed to calculate the fixation probabilities on complete bipartite digraphs (CBDs), and some conjectures are finally given through simulations

The effect of Vasohibin-1 expression and tumor-associated macrophages on the angiogenesis in vitro and in vivo

Peer reviewe

An efficient intelligent algorithm based on WSNs of the drug control system

U radu se predlaže novi algoritam, ACORS-ANNDPF za WSNs (bežične senzorske mreže), u svrhu povećanja stope uporabe WSNs i produženja životnog ciklusa Iot-a (Interneta stvari). Razvijen na temelju algoritma kolonije mrava, ovaj se poboljšani algoritam može primijeniti na izbor optimalne putanje i prepoznavanje optimalnog čvora za usmjeravanje u slučaju gubljenja čvora usmjeravanja. Kako bi se smanjilo vrijeme utrošeno na premiještanje skupine mreža, algoritam neuronske mreže odabire pokazatelje u skladu s aktualnim aplikacijskim okruženjem i podešava ih u svrhu optimiziranja podataka skupine. Nakon toga, autor provodi nekoliko simulacijskih eksperimenata i uspoređuje predloženi algoritam s drugim algoritmima. Rezultati pokazuju da se predloženim algoritmom osigurava visoka učinkovitost energije i balansirana potrošnja energije. Prema tome, zaključeno je da se predloženim algoritmom može poboljšati brzina uporabe mreže i povećati prijenosna funkcija mreže.A new algorithm, ACORS-ANNDPF for WSNs, is proposed in this paper to improve the utilization rate of WSNs and prolong the life cycle of the IoT. Developed on the basis of ant colony algorithm, the improved algorithm is applicable to the selection of the optimal path and identification of the optimal routing node in the case of losing the routing node. To reduce the time spent on transferring network packets, the indices are selected by the neural network algorithm in light of the actual application environment and adjusted to optimize the fusion of packet data. After that, the author carries out several simulation experiments and compares the proposed algorithm with other algorithms. The results demonstrate that the proposed algorithm ensures high energy efficiency and balanced energy consumption. Therefore, it is concluded that the proposed algorithm can improve network utilization rate and lead to better network transmission performance

Tumor-associated macrophages regulate gastric cancer cell invasion and metastasis through TGF beta 2/NF-kappa B/Kindlin-2 axis

Objective: Recent studies have shown that tumor-associated macrophages (TAMs) play an important role in cancer invasion and metastasis. Our previous studies have reported that TAMs promote the invasion and metastasis of gastric cancer (GC) cells through the Kindlin-2 pathway. However, the mechanism needs to be clarified. Methods: THP-1 monocytes were induced by PMA/interleukin (IL)-4/IL-13 to establish an efficient TAM model in vitro and M2 macrophages were isolated via flow cytometry. A dual luciferase reporter system and chromatin immunoprecipitation (ChIP) assay were used to investigate the mechanism of transforming growth factor beta 2 (TGF beta 2) regulating Kindlin-2 expression. Immunohistochemistry was used to study the relationships among TAM infiltration in human GC tissues, Kindlin-2 protein expression, clinicopathological parameters and prognosis in human GC tissues. A nude mouse oncogenesis model was used to verify the invasion and metastasis mechanisms in vivo. Results: We found that Kindlin-2 expression was upregulated at both mRNA and protein levels in GC cells cocultured with TAMs, associated with higher invasion rate. Kindlin-2 knockdown reduced the invasion rate of GC cells under coculture condition. TGF beta 2 secreted by TAMs regulated the expression of Kindlin-2 through the transcription factor NF-kappa B. TAMs thus participated in the progression of GC through the TGF beta 2/NF-kappa B/Kindlin-2 axis. Kindlin-2 expression and TAM infiltration were significantly positively correlated with TNM stage, and patients with high Kindlin-2 expression had significantly poorer overall survival than patients with low Kindlin-2 expression. Furthermore, Kindlin-2 promoted the invasion of GC cells in vivo. Conclusions: This study elucidates the mechanism of TAMs participating in GC cell invasion and metastasis through the TGF beta 2/NF-kappa B/Kindlin-2 axis, providing a possibility for new treatment options and approaches.Peer reviewe

Individual Differences in the Neural Basis of Response Inhibition After Sleep Deprivation Are Mediated by Chronotype

Sleep deprivation (SD) has been reported to severely affect executive function, and interindividual differences in these effects may contribute to the SD-associated cognition impairment. However, it is unclear how individual differences in chronotypes (morning-type, MT; evening-type, ET) influence neurobehavioral functions after SD. To address this question, we used functional magnetic resonance imaging (fMRI) to evaluate whether 24 h of SD differentially affect response inhibition, a core component of executive function, in MT and ET individuals. Accordingly, MT and ET participants were instructed to follow their preferred 7–9-h sleep schedule for 2 weeks at home both prior to and throughout the course of the study, and then performed a go/no-go task during fMRI scanning at 08:00 a.m. both at rested wakefulness (RW) and following SD. We also examined whether the neurobehavioral inhibition differences in the chronotypes in each session can be predicted by subjective ratings (sleepiness, mood, and task) or objective attention. Behaviorally, SD led to an increased response time of go trials (hit RT), more attentional lapses, higher subjective sleepiness, and worse mood indices, but it did not impair the accuracy of go trials (hit rate) and no-go trials (stop rate). Regardless of the presence of SD, ET individuals exhibited a lower stop rate, higher subjective ratings of sleepiness, exhausted mood, and task difficulty in comparison with MT individuals. On the neural level, SD resulted in decreased inhibition-related activation of the right lateral inferior frontal gyrus (rIFG) in MT individuals and increased rIFG activation in ET individuals. Moreover, the rIFG activation in ET individuals after SD was positively correlated to the subjective ratings of sleepiness and effort put into the task, which was considered as a compensatory response to the adverse effects of SD. These findings suggest that individual differences in inhibition-related cerebral activation after SD are influenced by chronotypes. In addition, ET individuals may be vulnerable to response inhibition. Thus, it is essential to take into consideration the chronotype in SD research and sleep medicine