Human sperm RNA code senses dietary sugar.

A new study reveals that a high-sugar diet acutely alters human sperm small RNA profiles after 1 week and that these changes are associated with changes in sperm motility. This rapid response by sperm to nutritional fluctuation raises intriguing questions regarding the underlying mechanisms and the potential effects on offspring metabolic health

College Students’ Career Planing Experiential Teaching Exploring

Using experiential teaching in career planning can effectively stimulate students’ learning initiative, improving the quality of teaching and curriculum’s effectiveness. This paper analyzes the current situation and the necessity of teaching career planning and how to use experiential teaching method in the education of career planning

Charmless B(s)→VVB_{(s)}\to VV Decays in Factorization-Assisted Topological-Amplitude Approach

Within the factorization-assisted topological-amplitude approach, we studied the 33 charmless $B_{(s)} \to VV$ decays, where $V$ stands for a light vector meson. According to the flavor flows, the amplitude of each process can be decomposed into 8 different topologies. In contrast to the conventional flavor diagrammatic approach, we further factorize each topological amplitude into decay constant, form factors and unknown universal parameters. By $\chi^2$ fitting 46 experimental observables, we extracted 10 theoretical parameters with $\chi^2$ per degree of freedom around 2. Using the fitted parameters, we calculated the branching fractions, polarization fractions, CP asymmetries and relative phases between polarization amplitudes of each decay mode. The decay channels dominated by tree diagram have large branching fractions and large longitudinal polarization fraction. The branching fractions and longitudinal polarization fractions of color-suppressed decays become smaller. Current experimental data of large transverse polarization fractions in the penguin dominant decay channels can be explained by only one transverse amplitude of penguin annihilation diagram. Our predictions of those not yet measured channels can be tested in the ongoing LHCb experiment and the Belle-II experiment in future.Comment: 22 pages, 2 figure

In silico model and design of novel 5α-reductase inhibitors for treatment of benign prostatic hyperplasia

Purpose: To carry out in silico design of 5α-reductase inhibitors and study their potential for use in the treatment of benign prostate hyperplasia (BPH). Methods: In silico molecular docking simulation-based virtual screening of NCI Diversity Set-II containing 1880 diverse ligands was performed against human 5α-reductase for identification of potential lead molecules. The pharmacological properties and toxicity of the lead compounds were determined using software, Marvin Sketch and OSIRIS online programs, respectively. Results: Three compounds: ZINC13099050, ZINC01569237 and ZINC17995347_2 showed potent inhibition of 5α-reductase enzyme protein and good pharmacokinetic properties without any serious toxic effects. Conclusion: The selected lead molecules are promising inhibitors of 5α-reductase. They are recommended for further structure-based development of drugs for the treatment of BPH

Improvement of colchicine oral bioavailability by incorporating eugenol in the nanoemulsion as an oil excipient and enhancer

The effect of eugenol on colchicine transport across an isolated rat intestinal membrane was studied using an in vitro diffusion chamber system. We found that eugenol increased the absorptive transport of the drug efficiently. The effect of eugenol on intestinal absorption of colchicine in an oral administrative nanoemulsion formulation was also demonstrated in vivo. The colchicine nanoemulsion was prepared with isopropyl myristate, eugenol, Tween80, ethanol and water, and eugenol was used as an oil phase in the formulation; an average particle size of this nanoemulsion was 41.2 ± 7.2 nm. The permeation of colchicine in the nanoemulsion across the intestinal membrane was significantly different from that of the control group (0.2 mM colchicine). Finally, co-administration of eugenol in colchicine nanoemulsion to enhance the colchicine bioavailability was investigated by an oral administration method. After oral administration of colchicine (8 mg/kg) in the form of either the nanoemulsion or in free colchicine solution, the relative bioavailability of nanoemulsion and eugenol–nanoemulsion were enhanced by about 1.6- and 2.1-fold, respectively, compared with free colchicine solution. The procedure indicated that the intestinal absorption of colchicine was enhanced significantly by eugenol in the tested nanoemulsion. All the results suggested that eugenol is an efficient component in an oral administrative formulation for improving the intestinal absorption of colchicine