381 research outputs found
KxFe2-ySe2 single crystals: Floating-zone growth, Transport and Structural properties
Single crystals of superconducting KxFe2-ySe2 have been grown with the
optical floating-zone technique under application of 8 bar of argon pressure.
We found that large and high quality single crystals with dimensions of
~\varnothing6 \times 10 mm could be obtained at the termination of the grown
ingot through quenching, while the remaining part of the ingot decomposed.
As-grown single crystals commonly represent an intergrowth of two sets of the
c-axis characterized by slightly different lattice constants. Single crystal of
K0.80Fe1.81Se2 shows a superconducting transition at Tc = 31.6 K, leading to a
near 100% expulsion of the external magnetic field in magnetization
measurements. On the other hand, neutron-diffraction data indicate that
superconductivity in the sample coexists with a iron-vacancy superstructure and
static antiferromagnetic order. The anisotropic ratio of the upper critical
field Hc2 for both H//c and H//ab configurations is \sim3.46
Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma.
Histone methyltransferase KMT2D harbors frequent loss-of-function somatic point mutations in several tumor types, including melanoma. Here, we identify KMT2D as a potent tumor suppressor in melanoma through an in vivo epigenome-focused pooled RNAi screen and confirm the finding by using a genetically engineered mouse model (GEMM) based on conditional and melanocyte-specific deletion of KMT2D. KMT2D-deficient tumors show substantial reprogramming of key metabolic pathways, including glycolysis. KMT2D deficiency aberrantly upregulates glycolysis enzymes, intermediate metabolites, and glucose consumption rates. Mechanistically, KMT2D loss causes genome-wide reduction of H3K4me1-marked active enhancer chromatin states. Enhancer loss and subsequent repression of IGFBP5 activates IGF1R-AKT to increase glycolysis in KMT2D-deficient cells. Pharmacological inhibition of glycolysis and insulin growth factor (IGF) signaling reduce proliferation and tumorigenesis preferentially in KMT2D-deficient cells. We conclude that KMT2D loss promotes tumorigenesis by facilitating an increased use of the glycolysis pathway for enhanced biomass needs via enhancer reprogramming, thus presenting an opportunity for therapeutic intervention through glycolysis or IGF pathway inhibitors
Metamagnetic transition in EuFeAs single crystals
We report the measurements of anisotropic magnetization and magnetoresistance
on single crystals of EuFeAs, a parent compound of ferro-arsenide
high-temperature superconductor. Apart from the antiferromagnetic (AFM)
spin-density-wave transition at 186 K associated with Fe moments, the compound
undergoes another magnetic phase transition at 19 K due to AFM ordering of
Eu spins (). The latter AFM state exhibits metamagnetic
transition under magnetic fields. Upon applying magnetic field with at 2 K, the magnetization increases linearly to 7.0 /f.u. at
=1.7 T, then keeps at this value of saturated Eu moments under
higher fields. In the case of , the magnetization increases
step-like to 6.6 /f.u. with small magnetic hysteresis. A metamagnetic
phase was identified with the saturated moments of 4.4 /f.u. The
metamagnetic transition accompanies with negative in-plane magnetoresistance,
reflecting the influence of Eu moments ordering on the electrical
conduction of FeAs layers. The results were explained in terms of
spin-reorientation and spin-reversal based on an -type AFM structure for
Eu spins. The magnetic phase diagram has been established.Comment: 10 pages, 8 figures. accepted for publication in New Journal of
Physics as a special issue articl
Evaluation of Genetic Susceptibility Loci for Chronic Hepatitis B in Chinese: Two Independent Case-Control Studies
BACKGROUND: A recent genome-wide scan has identified two genetic variants in the HLA-DP region strongly associated with hepatitis B infection in Japanese. This study evaluates the effects of these risk variants in Chinese, where the HBV infection is the most popular in the world. METHODS AND FINDINGS: We have assessed the relationship between these two single nucleotide polymorphisms (rs3077 and rs9277535) and chronic hepatitis B infection in two independent case-control studies. The first population in Chinese Han included 736 patients and 782 spontaneously recovered controls. The second set was established in Chinese Zhuang minority of 177 patients and 208 controls. Both A alleles of rs3077 and rs9277535 significantly deceased the risk to CHB in Chinese Han (OR = 0.540, 95%CI: 0.464-0.628, P = 4.068×10(-16) and OR = 0.696, 95%CI: 0.601-0.806, P = 1.062×10(-6), respectively). Conceivably, rs9277535 was found to be associated with decreased risk of the disease in Chinese Zhuang, with an OR of 0.606 (95%CI, 0.441-0.833, P = 0.002). CONCLUSION: Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population. These findings might provide clues to develop screening and surveillance strategies
Observation of decays to and
Using a data sample of events collected with
the BESIII detector, we report the first observation of the four-lepton-decays
and utilizing the process
. The branching fractions are determined to be
and
, respectively. The
results deviate from theoretical predictions, by 2.8 and 5.2 ,
respectively. No significant signal is observed for , and an upper limit on the branching fraction is set at
at the 90 confidence level. A CP asymmetry observable
is constructed for the first two channels, which is measured to be
and , respectively. No
evidence for CP violation is observed in this process.Comment: 9 pages, 1 figur
Upregulation of Circulating PD-L1/PD-1 Is Associated with Poor Post-Cryoablation Prognosis in Patients with HBV-Related Hepatocellular Carcinoma
BACKGROUND: The programmed cell death-1 receptor/programmed cell death-1 ligand (PD-1/PD-L1) pathway plays a crucial role in tumor evasion from host immunity. This study was designed to evaluate the association between circulating PD-L1/PD-1 and prognosis after cryoablation in patients with HBV-related hepatocellular carcinoma (HCC). METHODOLOGY/PRINCIPAL FINDINGS: In the present study, 141 HBV-related HCC patients were enrolled and of those 109 patients received cryoablation. Circulating PD-L1/PD-1 expression was tested by flow cytometry, and 23 patients were simultaneously evaluated for intratumoral PD-L1 expression by immunohistochemical staining. Circulating PD-1/PD-L1 expression was associated with severity of diseases in patients with HCC, and the circulating PD-L1 expression was closely correlated with intratumoral PD-L1 expression. Of the clinical parameters, PD-1/PD-L1 expression was associated with tumor size, blood vessel invasion and BCLC staging. Moreover, PD-1/PD-L1 expression dropped after cryoablation while being elevated at the time of tumor recurrence. Patients with higher expression of circulating PD-L1, as well as circulating PD-1, had a significantly shorter overall survival and tumor-free survival than those with lower expression. Multivariate analysis confirmed that circulating PD-L1 could serve as an independent predictor of overall survival and tumor-recurrence survival in HCC patients after cryoablation. CONCLUSIONS/SIGNIFICANCE: Upregulation of circulating PD-L1/PD-1 is associated with poor post-cryoablation prognosis in patients with HBV-related hepatocellular carcinoma
Study of
Based on a data sample of events
collected with the BESIII detector at the BEPCII collider, the branching
fraction of is measured to be
for the first time. In
addition, the (or ) invariant mass spectra
is studied and the potential presence of excited states has been
investigated
Measurement of the Cross Section for e^{+}e^{-}→Hadrons at Energies from 2.2324 to 3.6710 GeV
Based on electron-positron collision data collected with the BESIII detector
operating at the Beijing Electron Positron Collider II storage rings, the value
of hadrons)/
is measured at 14 center-of-mass energies from 2.2324 to 3.6710 GeV. The
resulting uncertainties are less than , and are dominated by systematic
uncertainties.Comment: 8 pages, 2 figure
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