8,831 research outputs found

    Cusp-scaling behavior in fractal dimension of chaotic scattering

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    A topological bifurcation in chaotic scattering is characterized by a sudden change in the topology of the infinite set of unstable periodic orbits embedded in the underlying chaotic invariant set. We uncover a scaling law for the fractal dimension of the chaotic set for such a bifurcation. Our analysis and numerical computations in both two- and three-degrees-of-freedom systems suggest a striking feature associated with these subtle bifurcations: the dimension typically exhibits a sharp, cusplike local minimum at the bifurcation.Comment: 4 pages, 4 figures, Revte

    Targeted Stimuli-Responsive Dextran Conjugates for Doxorubicin Delivery to Hepatocytes

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    A targeted, stimuli-responsive, polymeric drug delivery vehicle has been developed to help alleviate the severe side-effects caused by narrow therapeutic window drugs. Doxorubicin, a commonly used chemotherapeutic agent has been conjugated to dextran by two different techniques. In the first method, doxorubicin and hepatocyte-targeting galactosamine were attached to dextran through amine bonds. Conjugation efficiency based on the amount loaded of each reactant varied from 1% to 50% for doxorubicin and from 2% to 20% for galactosamine, depending on various synthesis parameters. For the second conjugate, doxorubicin was attached to dextran through an acid-labile hydrazide bond. Fluorescence quenching indicated that all our conjugates can bind to DNA. The degree of binding was improved with increasing polymer molecular weight and substitution of doxorubicin, and also with hydrazide-bonded conjugate. In cell culture experiments, we have found that the uptake of conjugates was much lower than that of free doxorubicin. Lower uptake of conjugates decreased the toxicity of doxorubicin. Also, the uptake of non-galactosylated conjugate was lower than that of the galactosylated conjugate. Microscopy studies indicated that doxorubicin was localized almost exclusively at the nucleus, whereas the amine-bonded conjugates were present throughout the cell. Targeted amine-linked conjugates and hydrazide-bonded conjugates achieved greatly improved cytotoxicity. Following uptake, the doxorubicin was dissociated from the hydrazide conjugate in an endosomal compartment and diffused to the nucleus. The LC₅₀ values of non-targeted amine-linked, targeted amine-linked, and hydrazide-linked doxorubicin were 19.81 ÎŒg/mL, 7.33 ÎŒg/mL and 4.39 ÎŒg/mL, respectively. The amine-linked conjugates were also tested on a multidrug-resistant cell line; the LC₅₀ values of doxorubicin and the non-targeted amine-linked conjugate were 8.60 ÎŒg/mL and 36.02 ÎŒg/mL, respectively.Singapore-MIT Alliance (SMA

    Dissipative chaotic scattering

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    We show that weak dissipation, typical in realistic situations, can have a metamorphic consequence on nonhyperbolic chaotic scattering in the sense that the physically important particle-decay law is altered, no matter how small the amount of dissipation. As a result, the previous conclusion about the unity of the fractal dimension of the set of singularities in scattering functions, a major claim about nonhyperbolic chaotic scattering, may not be observable.Comment: 4 pages, 2 figures, revte

    Study of pure annihilation type decays B→Ds∗KB \to D_s^{*} K

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    In this work, we calculate the rare decays B0→Ds∗−K+B^0 \to D_s^{*-} K^+ and B+→Ds∗+Kˉ0B^+ \to D_s^{*+} \bar{K}^0 in perturbative QCD approach with Sudakov resummation. We give the branching ratio of 10−510^{-5} for B0→Ds∗−K+B^0 \to D_s^{*-}K^+, which will be tested soon in BB factories. The decay B+→Ds∗+Kˉ0B^+ \to D_s^{*+} \bar{K}^0 has a very small branching ratio at O(10−8){\cal O}(10^{-8}), due to the suppression from CKM matrix elements ∣Vub∗Vcd∣|V_{ub}^* V_{cd}|. It may be sensitive to new physics contributions.Comment: 14 pages, 1 figur

    A new topological aspect of the arbitrary dimensional topological defects

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    We present a new generalized topological current in terms of the order parameter field ϕ⃗\vec \phi to describe the arbitrary dimensional topological defects. By virtue of the % \phi-mapping method, we show that the topological defects are generated from the zero points of the order parameter field ϕ⃗\vec \phi, and the topological charges of these topological defects are topological quantized in terms of the Hopf indices and Brouwer degrees of ϕ\phi-mapping under the condition that the Jacobian % J(\frac \phi v)\neq 0. When J(ϕv)=0J(\frac \phi v)=0, it is shown that there exist the crucial case of branch process. Based on the implicit function theorem and the Taylor expansion, we detail the bifurcation of generalized topological current and find different directions of the bifurcation. The arbitrary dimensional topological defects are found splitting or merging at the degenerate point of field function ϕ⃗\vec \phi but the total charge of the topological defects is still unchanged.Comment: 24 pages, 10 figures, Revte

    Spin ordering quantum transitions of superconductors in a magnetic field

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    We argue that recent neutron scattering measurements by Lake et. al. (Science 291, 1759 (2001)) of the spin excitation spectrum of LSCO in a magnetic field can be understood in terms of proximity to a phase with co-existing superconductivity and spin density wave order. We present a general theory for such quantum transitions, and argue that their low energy spin fluctuations are controlled by a singular correction from the superflow kinetic energy, acting in the region outside the vortex cores. We propose numerous experimental tests of our theory.Comment: 4 pages, 3 eps fig

    Electron Glass in Ultrathin Granular Al Films at Low Temperatures

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    Quench-condensed granular Al films, with normal-state sheet resistance close to 10 kΩ/□\Omega/\Box, display strong hysteresis and ultraslow, non-exponential relaxation in the resistance when temperature is varied below 300 mK. The hysteresis is nonlinear and can be suppressed by a dc bias voltage. The relaxation time does not obey the Arrhenius form, indicating the existence of a broad distribution of low energy barriers. Furthermore, large resistance fluctuations, having a 1/f-type power spectrum with a low-frequency cut-off, are observed at low temperatures. With decreasing temperature, the amplitude of the fluctuation increases and the cut-off frequency decreases. These observations combine to provide a coherent picture that there exists a new glassy electron state in ultrathin granular Al films, with a growing correlation length at low temperatures.Comment: RevTeX 3.1, 4 pages, 4 figures (EPS files) (Minor Additions

    A Cosmological Model with Dark Spinor Source

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    In this paper, we discuss the system of Friedman-Robertson-Walker metric coupling with massive nonlinear dark spinors in detail, where the thermodynamic movement of spinors is also taken into account. The results show that, the nonlinear potential of the spinor field can provide a tiny negative pressure, which resists the Universe to become singular. The solution is oscillating in time and closed in space, which approximately takes the following form g_{\mu\nu}=\bar R^2(1-\delta\cos t)^2\diag(1,-1,-\sin^2r ,-\sin^2r \sin^2\theta), with Rˉ=(1∌2)×1012\bar R= (1\sim 2)\times 10^{12} light year, and ÎŽ=0.96∌0.99\delta=0.96\sim 0.99. The present time is about t∌18∘t\sim 18^\circ.Comment: 13 pages, no figure, to appear in IJMP
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