An Empirical Analysis on Purchase Intention on Coffee Beverage in Taiwan

Coffee is the most popular beverage in the world. However, in Taiwan, coffee is a second option for beverage choice after tea, which is the traditional beverage of this nation. Under the impact of Western culture, the habit of Taiwanese on beverage has become gradually change. In the recent years, the rapid growth of the various coffee supply channels such as coffee shop, coffee chains, fast food restaurants and convenience stores has assisted in creating a huge market for consumption coffee. Thus, understanding consumer’s habit on coffee purchasing in non-coffee drinking habit market is crucial. It can offer some important information for coffee suppliers to formulate their market strategies in Taiwan. Therefore, in this study, the determinants of Taiwanese coffee drinker in purchasing coffee are defined. Results from 260 respondents were analysed by exploratory factor analysis and regression analysis. The findings demonstrate that brand & price, product image, promotion & advertising, motivation, atmosphere & environment and taste are critical factors which impact on coffee drinker’s purchase intention. Among that, promotion & advertising plays the principal role to attract customers. Therefore, in order to create competitive advantages in the coffee beverage industry, the actions of promotion and advertising should be strong by coffee supplier. Besides, how to produce high quality of coffee beverages and maintain to meet the requirements of drinker's for good flavor and taste also must be considered. Keywords: coffee beverage, purchase intention, Taiwa

A novel HIV-1 restriction factor that is biologically distinct from APOBEC3 cytidine deaminases in a human T cell line CEM.NKR

<p>Abstract</p> <p>Background</p> <p>Isolation of novel retroviral restriction factors will open new avenues for anti-HIV/AIDS treatment. Although HIV-1 replication is restricted by APOBEC3G/APOBEC3F, TRIM5α, and CD317, none defend HIV-1 infection under natural conditions. Previously, we demonstrated a host factor from the human T cell line CEM.NKR that potently restricted wild-type HIV-1 replication. Interestingly, this restriction resembled the APOBEC3G/APOBEC3F pattern in that viral replication was inhibited from the second round of replication cycle at a post-entry step.</p> <p>Results</p> <p>Here, we further characterized this factor and found it distinguishable from the known anti-HIV APOBEC3 proteins. Although CEM.NKR cells expressed both APOBEC3G and APOBEC3F, their levels were at least 10 or 4-fold lower than those in H9 cells, and importantly, Vif effectively neutralized their activity. Among eight subclones isolated from CEM.NKR cells, one was relatively permissive, four were semi-permissive, and three were completely non-permissive for HIV-1 replication. When the levels of APOBEC3 expression were determined, all these clones retained similar low levels of APOBEC3DE, APOBEC3F, APOBEC3G and APOBEC3H expression, and no APOBEC3B expression was detected. Since the <it>vif </it>from SIVmac can effectively neutralize APOBEC3B and APOBEC3H, recombinant HIV-1 expressing this SIV gene were created. However, these viruses still failed to replicate in CEM.NKR cells. We also confirmed that HIV-1 restriction in CEM.NKR was not due to a loss of calnexin expression.</p> <p>Conclusion</p> <p>Taken together, these results not only demonstrate that all these aforementioned anti-HIV APOBEC3 proteins do not contribute to this HIV-1 restriction, but also shed light on a novel and potent HIV-1 inhibitor in CEM.NKR cells.</p

Prompt-based All-in-One Image Restoration using CNNs and Transformer

Image restoration aims to recover the high-quality images from their degraded observations. Since most existing methods have been dedicated into single degradation removal, they may not yield optimal results on other types of degradations, which do not satisfy the applications in real world scenarios. In this paper, we propose a novel data ingredient-oriented approach that leverages prompt-based learning to enable a single model to efficiently tackle multiple image degradation tasks. Specifically, we utilize a encoder to capture features and introduce prompts with degradation-specific information to guide the decoder in adaptively recovering images affected by various degradations. In order to model the local invariant properties and non-local information for high-quality image restoration, we combined CNNs operations and Transformers. Simultaneously, we made several key designs in the Transformer blocks (multi-head rearranged attention with prompts and simple-gate feed-forward network) to reduce computational requirements and selectively determines what information should be persevered to facilitate efficient recovery of potentially sharp images. Furthermore, we incorporate a feature fusion mechanism further explores the multi-scale information to improve the aggregated features. The resulting tightly interlinked hierarchy architecture, named as CAPTNet, despite being designed to handle different types of degradations, extensive experiments demonstrate that our method performs competitively to the task-specific algorithms

Acupuncture for cancer pain in adults.

BACKGROUND: Forty percent of individuals with early or intermediate stage cancer and 90% with advanced cancer have moderate to severe pain and up to 70% of patients with cancer pain do not receive adequate pain relief. It has been claimed that acupuncture has a role in management of cancer pain and guidelines exist for treatment of cancer pain with acupuncture. OBJECTIVES: To evaluate efficacy of acupuncture for relief of cancer-related pain in adults. SEARCH STRATEGY: CENTRAL, MEDLINE, EMBASE, PsycINFO, AMED, and SPORTDiscus were searched up to November 2010 including non-English language papers. SELECTION CRITERIA: Randomised controlled trials (RCTs) evaluating any type of invasive acupuncture for pain directly related to cancer in adults of 18 years or over. DATA COLLECTION AND ANALYSIS: It was planned to pool data to provide an overall measure of effect and to calculate the number needed to treat to benefit, but this was not possible due to heterogeneity. Two review authors (CP, OT) independently extracted data adding it to data extraction sheets. Quality scores were given to studies. Data sheets were compared and discussed with a third review author (MJ) who acted as arbiter. Data analysis was conducted by CP, OT and MJ. MAIN RESULTS: Three RCTs (204 participants) were included. One high quality study investigated the effect of auricular acupuncture compared with auricular acupuncture at 'placebo' points and with non-invasive vaccaria ear seeds attached at 'placebo' points. Participants in two acupuncture groups were blinded but blinding wasn't possible in the ear seeds group because seeds were attached using tape. This may have biased results in favour of acupuncture groups. Participants in the real acupuncture group had lower pain scores at two month follow-up than either the placebo or ear seeds group.There was high risk of bias in two studies because of low methodological quality. One study comparing acupuncture with medication concluded that both methods were effective in controlling pain, although acupuncture was the most effective. The second study compared acupuncture, point-injection and medication in participants with stomach cancer. Long-term pain relief was reported for both acupuncture and point-injection compared with medication during the last 10 days of treatment. Although both studies have positive results in favour of acupuncture they should be viewed with caution due to methodological limitations, small sample sizes, poor reporting and inadequate analysis. AUTHORS' CONCLUSIONS: There is insufficient evidence to judge whether acupuncture is effective in treating cancer pain in adults

Identification of Molecular Determinants from Moloney Leukemia Virus 10 Homolog (MOV10) Protein for Virion Packaging and Anti-HIV-1 Activity

Background: MOV10 inhibits HIV-1 replication after being packaged. Results: A Gag binding plus all but one of seven helicase domains are required for MOV10 packaging. Nearly all residues are required for anti-HIV-1 activity. Conclusion: Gag binding is not sufficient for MOV10 packaging, and multiple discontinuous domains regulate MOV10 activity. Significance: These findings uncover a new packaging mechanism and provide new insights into MOV10 antiviral activity

Parallel session 4 :Teaching and learning innovations

Presented Titles: Higher Education and COVID-19: Is Hybrid Teaching/Learning the Solution? [Author: Francis Arthur-Holmes] Technology-enabled Teaching and Learning in COVID-19: Implication for Professional Development in Hong Kong’s Post-secondary Colleges [Authors: Beatrice Yan-yan Dang; Hayes Hei-hang Tang; Joanna WY Yeung] Hybrid Learning: Online Learning in a Residential Environment [Authors: Ying Xiong; Jingduo Bi] Hybrid Education and Collaborative Learning: A Natural Experiment During COVID-19 [Authors: Luyao Zhang; Ying Xiong; Jiaxin Wu] Catching Teachers Off Guard from Remote Learning: An Implication of Innovative Teaching Training in Hong Kong [Authors: Derek Wai-sun Chun; Siu-ho Yau; Wai-man Chan

Clinical features and familial mutations in the coexistence of Wilson's disease and Alport syndrome: A case report

BackgroundAlport syndrome (AS) and Wilson's disease (WD) are genetic diseases that could lead to kidney damage. Herein, we report the clinical features and gene variants in a patient with WD and X-linked AS.Case presentationThe proband was a 12-year-old boy diagnosed with AS coexisting with WD at the age of 11 years. The patient underwent a medical check-up when he was 4 years and 8 months. Laboratory tests revealed elevated liver enzymes, decreased serum ceruloplasmin, increased 24-h urinary copper excretion, and one variant in the ATP7B gene. Then, the patient was diagnosed with WD. After 2 months of treatment with D-penicillamine and zinc salt, his liver function had recovered to normal levels, but he presented with microscopic hematuria. The hematuria did not resolve after switching to dimercaptosuccinic acid from D-penicillamine. In addition, he presented with proteinuria 3 years later. A renal biopsy was performed more than 6 years after the patient was diagnosed with WD, and electron microscopy showed that the basement membrane thickness was uneven, layered, and focal torn. Copper staining was negative. A genetic analysis identified a hemizygous variant (c.1718G &gt; A, p. Gly573Asp) in COL4A5 and a homozygous variant (c.2975C &gt; T, p. Pro992leu) in ATP7B. The patient’s urine protein–creatinine ratio was less than 1.0 mg/mg after a 1 year of follow-up, after enalapril was administered for treating AS.ConclusionThis case highlights a lack of improvement in renal function after conventional treatment provides a possible indication for performing renal biopsy or genetic testing to determine the etiology in order to facilitate subsequent clinical management. Clinicians should prevent the occurrence of diagnostic inaccuracies caused by diagnostic anchoring because an accurate diagnosis is essential for achieving precise treatment and improved prognosis