Enabling Full-Stack Quantum Computing with Changeable Error-Corrected Qubits

Executing quantum applications with quantum error correction (QEC) faces the gate non-universality problem imposed by the Eastin-Knill theorem. As one resource-time-efficient solution, code switching changes the encoding of logical qubits to implement universal logical gates. Unfortunately, it is still unclear how to perform full-stack fault-tolerant quantum computing (FTQC) based on the changeable logical qubit. Specifically, three critical problems remain unsolved: a) how to implement the dynamic logical qubit on hardware; b) how to determine the appropriate timing for logical qubit varying; c) how to improve the overall system performance for programs of different features. To overcome those design problems, We propose CECQ, to explore the large design space for FTQC based on changeable logical qubits. Experiments on various quantum programs demonstrate the effectiveness of CECQ

Optimal Synthesis of Stabilizer Codes via MaxSAT

Quantum Error Correction (QEC) codes are crucial for achieving fault-tolerant quantum computing in the long term. However, efficiently implementing these codes on hardware poses significant challenges, including hardware connectivity matching, efficient circuit scheduling, and fault-tolerance enforcement. In this study, we present an optimal synthesizer that stitches generic stabilizer codes onto diverse hardware structures via MaxSAT. Our evaluation demonstrates (1) the capability of our approach to be applied for various codes and devices and (2) the consistently better efficiency than the best prior heuristic approaches that only target specific QEC codes. By bridging the gap between high-level QEC code design and low-level hardware constraints, this work paves the way toward achieving long-term fault-tolerant quantum computing goals

Compilation for Quantum Computing on Chiplets

Chiplet architecture is an emerging architecture for quantum computing that could significantly increase qubit resources with its great scalability and modularity. However, as the computing scale increases, communication between qubits would become a more severe bottleneck due to the long routing distances. In this paper, we trade ancillary qubits for program concurrency by proposing a multi-entry communication highway mechanism, and building a compilation framework to efficiently manage and utilize the highway resources. Our evaluation shows that this framework significantly outperforms the baseline approach in both the circuit depth and the number of operations on some typical quantum benchmarks, leading to a more efficient and less error-prone compilation of quantum programs

Non-Invasive Brain Stimulation: Augmenting the Training and Performance Potential in Esports Players

During the last two decades, esports, a highly competitive sporting activity, has gained increasing popularity. Both performance and competition in esports require players to have fine motor skills and physical and cognitive abilities in controlling and manipulating digital activities in a virtual environment. While strategies for building and improving skills and abilities are crucial for successful gaming performance, few effective training approaches exist in the fast-growing area of competitive esports. In this paper, we describe a non-invasive brain stimulation (NIBS) approach and highlight the relevance and potential areas for research while being cognizant of various technical, safety, and ethical issues related to NIBS when applied to esports

Maternal serum disintegrin and metalloprotease protein-12 in early pregnancy as a potential marker of adverse pregnancy outcomes.

The aim of this study was to determine whether the concentration of disintegrin and metalloprotease protein12 (ADAM12) in first trimester maternal serum can be used as a marker for first-trimester complete spontaneous abortions, missed abortions, ectopic pregnancies and hydatidiform moles.The maternal serum concentrations of ADAM12 were measured in the range of 5-9+6 weeks of gestation using an automated AutoDelfia immunoassay platform in 9 cases of complete spontaneous abortion, 27 cases of missed abortions, 56 cases of ectopic pregnancies, 12 cases of hydatidiform moles, and 100 controls. Logistic regression analysis was used to determine significant factors for predicting adverse pregnancy outcomes in early pregnancy. Screening performance was assessed using receiver operating characteristic curves.Two hundred and four women were enrolled in the study. In the control group, the level of ADAM12 increased with gestational age. The median ADAM12 levels in the spontaneous abortion (0.430 MoM), ectopic pregnancy (0.460 MoM) and hydatidiform mole (0.037 MoM) groups were lower than that in the control group, while the median ADAM12 level in the missed abortion group (1.062 MoM) was not significant from the controls (1.002 MoM). Logistic regression analysis demonstrated that the level of ADAM12 in maternal serum facilitated the detection of ectopic pregnancies (OR = 0.909; 95% CI = 0.841 ∼ 0.982) and complete spontaneous abortion (OR = 0.863; 95% CI = 0.787 ∼ 0.946).In complete spontaneous abortion and ectopic pregnancy, ADAM12 maintained at low levels in early pregnancies, and there were significant differences compared to normal pregnancies. ADAM12 is a promising marker for the diagnosis of complete spontaneous abortion and ectopic pregnancy in symptomatic women, and under certain conditions, ADAM12 can diagnose ectopic pregnancy and spontaneous abortion before an ultrasonographic detection of the conditions

Maternal serum disintegrin and metalloprotease protein-12 in early pregnancy as a potential marker of adverse pregnancy outcomes.

The aim of this study was to determine whether the concentration of disintegrin and metalloprotease protein12 (ADAM12) in first trimester maternal serum can be used as a marker for first-trimester complete spontaneous abortions, missed abortions, ectopic pregnancies and hydatidiform moles.The maternal serum concentrations of ADAM12 were measured in the range of 5-9+6 weeks of gestation using an automated AutoDelfia immunoassay platform in 9 cases of complete spontaneous abortion, 27 cases of missed abortions, 56 cases of ectopic pregnancies, 12 cases of hydatidiform moles, and 100 controls. Logistic regression analysis was used to determine significant factors for predicting adverse pregnancy outcomes in early pregnancy. Screening performance was assessed using receiver operating characteristic curves.Two hundred and four women were enrolled in the study. In the control group, the level of ADAM12 increased with gestational age. The median ADAM12 levels in the spontaneous abortion (0.430 MoM), ectopic pregnancy (0.460 MoM) and hydatidiform mole (0.037 MoM) groups were lower than that in the control group, while the median ADAM12 level in the missed abortion group (1.062 MoM) was not significant from the controls (1.002 MoM). Logistic regression analysis demonstrated that the level of ADAM12 in maternal serum facilitated the detection of ectopic pregnancies (OR = 0.909; 95% CI = 0.841 ∼ 0.982) and complete spontaneous abortion (OR = 0.863; 95% CI = 0.787 ∼ 0.946).In complete spontaneous abortion and ectopic pregnancy, ADAM12 maintained at low levels in early pregnancies, and there were significant differences compared to normal pregnancies. ADAM12 is a promising marker for the diagnosis of complete spontaneous abortion and ectopic pregnancy in symptomatic women, and under certain conditions, ADAM12 can diagnose ectopic pregnancy and spontaneous abortion before an ultrasonographic detection of the conditions

Smart Chemiluminescence Probes and Dual-Amplification of Signal for Detection of Amyloid Beta Species in Alzheimer’s Disease Model

Fluorescence and chemiluminescence imaging are the most widely applied optical emissive imagingmethods in biomedical research. “Smart” (turn-on) fluorescence imaging has been routinely used for invitro, cellular, and in vivo imaging; however, smart chemiluminescence imaging has been rarely explored.In this report, we designed chemiluminescence probe ADLumin-1 and validated that ADLumin-1 was asmart chemiluminescence probe for amyloid beta (Ab) species, evidenced by a 216-fold amplification ofchemiluminescence intensity upon mixing with Abs in vitro. In vivo two photon imaging indicated thatADLumin-1 could efficiently cross blood-brain- barrier (BBB) and provided excellent contrast both for Abplaques and cerebral amyloid angiopathy (CAA). In vivo whole brain imaging showed that thechemiluminescence signal of ADLumin-1 from 5-month-old transgenic AD (5xFAD) mice was 1.80-foldhigher than that from the age-matched wild-type mice. Moreover, we demonstrated that it was feasible tofurther dually-amplify signal via chemiluminescence resonance energy transfer (DAS-CRET) using twonon-conjugated smart probes (ADLumin-1 and CRANAD-3) in solutions, brain homogenates, and in vivowhole brain imaging. Our results showed that DAS-CRET could provide a 2.25-fold margin between 5-month-old 5xFAD mice and wild type mice. To our knowledge, this is the first report that achemiluminescence probe could be used for detecting Ab species both in vitro and in vivo. AlthoughADLumin-1 was designed for Abs, we believe that our strategy could be potentially extended to a widerange of targets, including other aggregating-prone proteins. Notably, our results suggested that thestrategies for turning-on fluorescence could be used for amplifying chemiluminescence, and we believe thatour studies could inspire considerably more research on chemiluminescence imaging</div

Growth Performance and Meat Quality of Broiler Chickens Supplemented with in Drinking Water

A feeding trial was conducted to investigate effects of Bacillus licheniformis on growth performance and meat quality of broilers. Nine hundred one-d-old broiler chicks were randomly assigned to 3 experimental groups with three replicate pens of 100 broiler chicks. Three treatments were i) control, ii) basal diets supplemented with 1 ml of B. licheniformis for each in feed water per day iii) basal diets supplemented with 2 ml of B. licheniformis per chick in feed water per day. The supplementation of B. licheniformis significantly increased body weight in grower chickens (p<0.05), and significantly improved the feed conversion in 3 to 6 and 0 to 6 wk feeding period compared with the control group (p<0.05). Additionally, the supplement also resulted in increased protein and free amino acid contents, and decreased fat content in chicken breast fillet (p<0.05). Furthermore, improvement in sensory attributes was observed in broilers fed with the probiotic. In conclusion, B. licheniformis treatments resulted in a significant increase (p<0.05) in broiler productivity based on an index taking into account daily weight gain and feed conversion rate. Meanwhile, the probiotic contributed towards an improvement of the chemical, nutritional and sensorial characteristics of breast fillet. Overall, the study indicates that B. licheniformis can be used as a growth promoter and meat quality enhancer in broiler poultry

Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo

Detection of amyloid beta deposits is often performed with fluorescent compounds that bind plaques. Here the authors develop turn-on chemiluminescent probes that bind amyloid beta plaques in vivo, and amplify the signal via chemiluminescence resonance energy transfer to the plaque-binding fluorescent molecule CRANAD-3

Maternal characteristics of the five outcome groups.

<p>Note: Data are the median (range).</p><p>Statistical tests of significance were by comparison with the control group using the Kruskal-Wallis test.</p