Analysis of Stator End-winding in a Dual Wound Machine Using Biot-Savart Law

Integrated full electric propulsion (IFEP) systems provide both ship propulsion and services with different electrical ratings. Instead of using multiple electrical machine sets, a dual wound machine with two sets of windings sharing the same stator slots can use one prime mover to provide two independent power supplies, achieving a more compact design and maximizing the power density. In order to provide independent power supplies, the windings must eliminate the electromagnetic coupling between them. A 2-pole and 6-pole dual wound machine has been designed previously. The simulation results show that there is no electromagnetic coupling considering the windings in the slots. It is important to investigate if there is any electromagnetic coupling caused by the end-windings. This paper proposes a simplified 2D and 3D end-winding model to analyse the magnetic field distribution and induced voltage using the Biot-Savart law. It is concluded that the end-windings of the dual wound machine are also not electromagnetically coupled, which proves that it is able to produce two independent power supplies for ship propulsion and services

End-to-End Learning for Simultaneously Generating Decision Map and Multi-Focus Image Fusion Result

The general aim of multi-focus image fusion is to gather focused regions of different images to generate a unique all-in-focus fused image. Deep learning based methods become the mainstream of image fusion by virtue of its powerful feature representation ability. However, most of the existing deep learning structures failed to balance fusion quality and end-to-end implementation convenience. End-to-end decoder design often leads to unrealistic result because of its non-linear mapping mechanism. On the other hand, generating an intermediate decision map achieves better quality for the fused image, but relies on the rectification with empirical post-processing parameter choices. In this work, to handle the requirements of both output image quality and comprehensive simplicity of structure implementation, we propose a cascade network to simultaneously generate decision map and fused result with an end-to-end training procedure. It avoids the dependence on empirical post-processing methods in the inference stage. To improve the fusion quality, we introduce a gradient aware loss function to preserve gradient information in output fused image. In addition, we design a decision calibration strategy to decrease the time consumption in the application of multiple images fusion. Extensive experiments are conducted to compare with 19 different state-of-the-art multi-focus image fusion structures with 6 assessment metrics. The results prove that our designed structure can generally ameliorate the output fused image quality, while implementation efficiency increases over 30\% for multiple images fusion.Comment: repor

Segmentation of Parotid Gland Tumors Using Multimodal MRI and Contrastive Learning

Parotid gland tumor is a common type of head and neck tumor. Segmentation of the parotid glands and tumors by MR images is important for the treatment of parotid gland tumors. However, segmentation of the parotid glands is particularly challenging due to their variable shape and low contrast with surrounding structures. Recently deep learning has developed rapidly, which can handle complex problems. However, most of the current deep learning methods for processing medical images are still based on supervised learning. Compared with natural images, medical images are difficult to acquire and costly to label. Contrastive learning, as an unsupervised learning method, can more effectively utilize unlabeled medical images. In this paper, we used a Transformer-based contrastive learning method and innovatively trained the contrastive learning network with transfer learning. Then, the output model was transferred to the downstream parotid segmentation task, which improved the performance of the parotid segmentation model on the test set. The improved DSC was 89.60%, MPA was 99.36%, MIoU was 85.11%, and HD was 2.98. All four metrics showed significant improvement compared to the results of using a supervised learning model as a pre-trained model for the parotid segmentation network. In addition, we found that the improvement of the segmentation network by the contrastive learning model was mainly in the encoder part, so this paper also tried to build a contrastive learning network for the decoder part and discussed the problems encountered in the process of building

Effectiveness of BNT162b2 and CoronaVac vaccinations against SARS-CoV-2 omicron infection in people aged 60 years or above: a case–control study

BACKGROUND: In view of limited evidence that specifically addresses vaccine effectiveness (VE) in the older population, this study aims to evaluate the real-world effectiveness of BNT162b2 and CoronaVac in older adults during the Omicron BA.2 outbreak. METHODS: This case-control study analyzed data available between January and March 2022 from the electronic health databases in Hong Kong and enrolled individuals aged 60 or above. Each case was matched with up to 10 controls by age, sex, index date and Charlson Comorbidity Index for the four outcomes (COVID-19 infection, COVID-19-related hospitalization, severe complications, and all-cause mortality) independently. Conditional logistic regression was conducted to evaluate VE of BNT162b2 and CoronaVac against COVID-19-related outcomes within 28 days after COVID-19 infection among participants stratified by age groups (60-79, ≥80 years old). RESULTS: A dose-response relationship between the number of vaccine doses received and protection against severe or fatal disease was observed. Highest VE (95% CI) against COVID-19 infection was observed in individuals aged ≥80 who received three doses of BNT162b2 [75.5% (73.1-77.7%)] or three doses of CoronaVac [53.9% (51.0-56.5%)] compared to those in the younger age group who received three doses of BNT162b2 [51.1% (49.9-52.4%)] or three doses of CoronaVac [2.0% (-0.1-4.1%)]. VE (95% CI) was higher for other outcomes, reaching 91.9% (89.4-93.8%) and 86.7% (84.3-88.8%) against COVID-19-related hospitalization; 85.8% (61.2-94.8%) and 89.8% (72.4-96.3%) against COVID-19-related severe complications; and 96.4% (92.9-98.2%) and 95.0% (92.1-96.8%) against COVID-19-related mortality after three doses of BNT162b2 and CoronaVac in older vaccine recipients, respectively. A similar dose-response relationship was established in younger vaccine recipients and after stratification by sex and Charlson Comorbidity Index. CONCLUSION: Both BNT162b2 and CoronaVac vaccination were effective in protecting older adults against COVID-19 infection and COVID-19-related severe outcomes amidst the Omicron BA.2 pandemic, and VE increased further with the third dose

Mimotope ELISA for Detection of Broad Spectrum Antibody against Avian H5N1 Influenza Virus

Science and Technology Foundation of Fujian Province [2009YZ0002]; National Natural Science Foundation of China [30901077]; National High Technology Research and Development Program [2010AA022801]Background: We have raised a panel of broad spectrum neutralizing monoclonal antibodies against the highly pathogenic H5N1 avian influenza virus, which neutralize the infectivity of, and afford protection against infection by, most of the major genetic groups of the virus evolved since 1997. Peptide mimics reactive with one of these broad spectrum H5N1 neutralizing antibodies, 8H5, were identified from random phage display libraries. Method: The amino acid residues of the most reactive 12mer peptide, p125 (DTPLTTAALRLV), were randomly substituted to improve its mimicry of the natural 8H5 epitope. Result: 133 reactive peptides with unique amino acid sequences were identified from 5 sub-libraries of p125. Four residues (2,4,5.9) of the parental peptide were preserved among all the derived peptides and probably essential for 8H5 binding. These are interspersed among four other residues (1,3,8,10), which exhibit restricted substitution and probably could contribute to binding, and another four (6,7,11,12) which could be randomly substituted and probably are not essential for binding. One peptide, V-1b, derived by substituting 5 of the latter residues is the most reactive and has a binding constant of 3.16x10(-9) M, which is 38 fold higher than the affinity of the parental p125. Immunoassay produced with this peptide is specifically reactive with 8H5 but not also the other related broad spectrum H5N1 avian influenza virus neutralizing antibodies. Serum samples from 29 chickens infected with H5N1 avian influenza virus gave a positive result by this assay and those from 12 uninfected animals gave a negative test result. Conclusion: The immunoassay produced with the 12 mer peptide, V1-b, is specific for the natural 8H5 epitope and can be used for detection of antibody against the broad spectrum neutralization site of H5N1 avian influenza virus

Vaccine Effectiveness of BNT162b2 and CoronaVac against SARS-CoV-2 Omicron BA.2 in CKD

Background: The ongoing coronavirus disease 2019 (COVID-19) pandemic has posed increased risks of hospitalization and mortality in patients with underlying CKD. Current data on vaccine effectiveness of COVID-19 vaccines are limited to patients with CKD on dialysis and seroconversion in the non-dialysis population. Methods: A case–control study was conducted of adults with CKD using data extracted from the electronic health record database in Hong Kong. Adults with CKD and COVID-19 confirmed by PCR were included in the study. Each case was matched with up to ten controls attending Hospital Authority services without a diagnosis of COVID-19 on the basis of age, sex, and index date (within three calendar days). The vaccine effectiveness of BNT162b2 and CoronaVac in preventing COVID-19 infection, hospitalizations, and all-cause mortality was estimated using conditional logistic regression adjusted by patients' comorbidities and medication history during the outbreak from January to March 2022. Results: A total of 20,570 COVID-19 cases, 6604 COVID-19–related hospitalizations, and 2267 all-cause mortality were matched to 81,092, 62,803, and 21,348 controls, respectively. Compared with the unvaccinated group, three doses of BNT162b2 or CoronaVac were associated with a reduced risk of infection (BNT162b2: 64% [95% confidence interval (CI), 60 to 67], CoronaVac: 42% [95% CI, 38 to 47]), hospitalization (BNT162b2: 82% [95% CI, 77 to 85], CoronaVac: 80% [95% CI, 76 to 84]), and mortality (BNT162b2: 94% [95% CI, 88 to 97], CoronaVac: 93% [95% CI, 88 to 96]). Vaccines were less effective in preventing infection and hospitalization in the eGFR <15 and 15–29 ml/min per 1.73 m2 subgroups as compared with higher GFR subgroups. However, receipt of vaccine, even for one dose, was effective in preventing all-cause mortality, with estimates similar to the higher eGFR subgroups, as compared with unvaccinated. Conclusions: A dose-response relationship was observed between the number of BNT162b2 or CoronaVac doses and the effectiveness against COVID-19 infection and related comorbidity in the CKD population

Root phosphatase activity is a competitive trait affiliated with the conservation gradient in root economic space

Background: The diversity of resource acquisition strategies of plant roots determines the species coexistence patterns to a certain extent. However, few root physiological traits have been investigated, such as root phosphatase activity (PA) that affects plant phosphorus (P) uptake. Methods: Root PA and classical root functional traits were investigated for 21 coexisting species in a deciduous broad-leaved forest in warm temperate-subtropical transition zone, China. We analyzed the root order variation of absorptive fine root PA, clarified the attribution of root PA in root economic space (RES) and the different P acquisition strategies of co-occurring species based on the multidimensional RES theory, and determined the dominant factors affecting interspecific variation in root PA. Results: There was no distinct pattern of PA variation with root order in the first three root orders of absorptive fine roots, and root PA was constrained by phylogeny. Root PA is a competitive trait affiliated with the conservation gradient in RES. The tight linkages among root PA, mycorrhizal colonization, diameter, specific root length, and nitrogen concentration suggested trade-offs among P acquisition strategies of co-occurring species, i.e. species with long and fine roots acquire inorganic P by actively exploring the soil and secreting phosphatase to mineralize and hydrolyze organic P, while species with short and thick roots obtain P mainly by investing C in mycorrhizal partners. Conclusions: Collectively, our study provides an insight into the forest species coexistence in climatic transition zones, i.e. species coexistence mechanisms based on diverse phosphorus acquisition strategies

Design and analysis of dual wound machine for electric ships

Integrated full electric propulsion systems eliminate the direct mechanical coupling between the prime mover and the propeller, enabling easier connection of multiple prime movers and allowing more equitable and fuel-efficient engine loading. These features are important in both cruise ship and naval warship design. Propulsion and ship service systems require different electrical ratings. The general solution is to use multiple electrical machine sets. To approach the most compact design and maximise the weight reduction, a dual wound machine is considered in this paper. It has dual two-layer windings which share the same slots and uses one prime mover, to produce two independent power supplies. This paper designs a dual wound machine with no electromagnetic coupling due to the airgap fields, by algebraically analyzing the harmonic distribution. Further verification of the nil electro-magnetic coupling due to both the airgap and slot leakage fluxes is provided by 2D finite element modeling. Both loaded and unloaded conditions are considered