THE EFFECT OF PREOPERATIVE ANXIETY ON FETAL CORD BLOOD TUMOR NECROSIS FACTOR-ALPHA, INTERLEUKIN-6, AND NEONATAL OUTCOMES IN PREGNANT WOMEN

Backgrounds: In this study, we aimed to investigate the relationship in pregnant women who undergo elective cesarean section between the preoperative anxiety (POA) levels and neonatal results and TNF-alfa,IL-6 and IL-8 levels, the pro-inflammatory cytokines in cord blood. Subjects and methods: Sixty-six volunteer patients, aged 18 to 40, who underwent elective cesarean surgery were included in the study. Trait Anxiety Inventory (TAI) was evaluated at the anesthesia outpatient clinic and State Anxiety Inventory (SAI) was determined one hour before cesarean section. Plasma levels of TNF-alfa,IL-6 and IL-8 in the umbilical cord blood were determined using the ELISA method. Fetal cord blood gas, birth weight, and APGAR scores at the 1st and 5th minutes after birth were recorded. Results: The mean preoperative maternal SAI and TAI scores were 46,6+-10,9 and 41,4+-7,8, respectively. There was a significant correlation between POA and fetal birth weight and fetal cord blood TNF-alfa,IL-6 and IL-8 parameters. The inflammatory marker levels in the cord blood of fetuses in the high anxiety groups were significantly higher (p<0.001). Fetal birth weight was significantly lower in the high anxiety groups (p<0.05), whereas there was no significant difference in cord blood gas values. Conclusions: Our results show that an increase in the levels of TNF-alfa,IL-6, and IL-8 cytokines in fetal cord blood in pregnant women with high anxiety levels and this situation causes negative effects on the newborn

THE EFFECT OF PREOPERATIVE ANXIETY ON FETAL CORD BLOOD TUMOR NECROSIS FACTOR-ALPHA, INTERLEUKIN-6, AND NEONATAL OUTCOMES IN PREGNANT WOMEN

Backgrounds: In this study, we aimed to investigate the relationship in pregnant women who undergo elective cesarean section between the preoperative anxiety (POA) levels and neonatal results and TNF-alfa,IL-6 and IL-8 levels, the pro-inflammatory cytokines in cord blood. Subjects and methods: Sixty-six volunteer patients, aged 18 to 40, who underwent elective cesarean surgery were included in the study. Trait Anxiety Inventory (TAI) was evaluated at the anesthesia outpatient clinic and State Anxiety Inventory (SAI) was determined one hour before cesarean section. Plasma levels of TNF-alfa,IL-6 and IL-8 in the umbilical cord blood were determined using the ELISA method. Fetal cord blood gas, birth weight, and APGAR scores at the 1st and 5th minutes after birth were recorded. Results: The mean preoperative maternal SAI and TAI scores were 46,6+-10,9 and 41,4+-7,8, respectively. There was a significant correlation between POA and fetal birth weight and fetal cord blood TNF-alfa,IL-6 and IL-8 parameters. The inflammatory marker levels in the cord blood of fetuses in the high anxiety groups were significantly higher (p<0.001). Fetal birth weight was significantly lower in the high anxiety groups (p<0.05), whereas there was no significant difference in cord blood gas values. Conclusions: Our results show that an increase in the levels of TNF-alfa,IL-6, and IL-8 cytokines in fetal cord blood in pregnant women with high anxiety levels and this situation causes negative effects on the newborn

Growth performance and biochemical profile of Azolla pinnata and Azolla caroliniana grown under greenhouse conditions

This study aimed to evaluate the growth performance, pigment content changes, essential amino acids (EAAs), fatty acids (FAs), and proximate composition of Azolla pinnata and Azolla caroliniana grown in a greenhouse. Plants were grown in nitrogen-free Hoagland's solution at 28 +/- 2 degrees C/21 +/- 2 degrees C, day/night temperature and 60-70% humidity and examined on the 3rd, 5th, 10th and 15th days. The mean percentage of plant growth and relative growth rate for A. pinnata were 119% and 0.148 gg(-1)day(-1), respectively, while for A. caroliniana these values were 94% and 0.120 gg(-1)day(-1), respectively. Compared to day 3, the amount of total chlorophyll obtained on day 15 decreased significantly (p0.0.5) in A. caroliniana. The crude protein, lipid, cellulose, ash values and the amounts of EAAs were higher in A. pinnata than A. caroliniana. Palmitic acid, oleic acid, and lignoceric acid were found to be predominant in A. pinnata and A. caroliniana. From the plant growth and pigment contents, we concluded that A. pinnata grew faster than A. caroliniana and its photosynthetic efficiency was more effective

Resistance or Thuggery?: Political Narratives of Urban Riots

Political scientists have discovered that most political categories (political authority, democratic legitimacy, identity building) are closely linked with the concept of narrative. We demonstrate the relevance of narrative analysis in politics by analyzing two cases of urban riots (Paris 2005, Baltimore 2015). We propose a micro-oriented perspective focusing on people’s everyday life experiences and cultural practices of storytelling. The analysis dissects state narratives, which discredit protests through the language of criminality. Our case examples show that sudden violence in urban riots is often a desperate expression of marginalized voices articulating moral claims of justice, particularly concerning everyday racism

Vasculitis and long standing ankylosing spondylitis in a patient with familial Mediterranean fever

Coexistence of familial Mediterranean fever (FMF) and other inflammatory disorders has been frequently reported, but no specific underlying factor has been identified. We report a patient with FMF who is presented with long-standing ankylosing spondylitis (AS) and cutaneous leukocytoklastic vasculitis (LV) of the lower limbs. It is the first report on combination of FMF with AS and LV. The Mediterranean Fever (MEFV) gene mutation of heterozygote (R202Q/R726A) and HLA-B27 are detected in this case, and are believed to form genetic susceptibility to LV

Comparison of the C-MAC video laryngoscope to the Macintosh laryngoscope for intubation of blunt trauma patients in the ED

Objectives: We aimed to compare the performance of the C-MAC video laryngoscope (C-MAC) to the Macintosh laryngoscope for intubation of blunt trauma patients in the ED. Material and methods: This was a prospective randomized study. The primary outcome measure is overall successful intubation. Secondary outcome measures are first attempt successful intubation, Cormack–Lehane (CL) grade, and indicators of the reasons for unsuccessful intubation at the first attempt with each device. Adult patients who suffered from blunt trauma and required intubation were randomized to video laryngoscopy with C-MAC device or direct laryngoscopy (DL). Results: During a 17-month period, a total of 150 trauma intubations were performed using a C-MAC and DL. Baseline characteristics of patients were similar between the C-MAC and DL group. Overall success for the C-MAC was 69/75 (92%, 95% CI 0.83 to 0.96) while for the DL it was 72/75 (96%, 95% CI 0.88 to 0.98). First attempt success for the C-MAC was 47/75 (62.7%, 95% CI 0.51 to 0.72) while for the DL it was 44/75 patients (58.7%, 95% CI 0.47 to 0.69). The mean time to achieve successful intubation was 33.4 ± 2.5 s for the C-MAC versus 42.4 ± 5.1 s for the DL (p = 0.93). There was a statistically significant difference between the DL and C-MAC in terms of visualizing the glottic opening and esophageal intubation in favor of the C-MAC (p = 0.002 and p = 0.013 respectively). Discussion and conclusion: The overall success rates were similar. The C-MAC demonstrated improved glottic view and decrease in esophageal intubation rate. Keywords: Airway management, Emergency medicine, Video laryngoscop

Heuristiken des politischen Entscheidens

Wo individuelle Nutzenkalküle und geteilte Erwartungen enden, beginnt das Terrain der Kunstfertigkeit. Unter der Annahme, dass politisches Entscheiden als pragmatischer Problemlösungs- und Abwägungsprozess zu betrachten ist, rollen die Beiträge dieses interdisziplinär angelegten Bandes die Frage neu auf, wie in der Politik unter Bedingungen begrenzter Rationalität Handlungsalternativen entworfen, verhandelt und ausgewählt werden. Die Pandemie hat diesem Anliegen eine ungeahnte Dramatik verliehen, eingeübte Grundsätze, Entscheidungsarenen und Praktiken der Politik stehen mehr denn je zur Disposition. Es ist an der Zeit, diese neu zu vermessen. (Verlagsangaben

Effects Of L-Thyroxine On Gastric Motility And Ghrelin In Subclinical Hypothyroidism: A Prospective Study

Introduction: Overt hypothyroidism affects the gastrointestinal system. Limited data are available regarding gastric motility in subclinical hypothyroidism (SCH). Objective: The aim of this study was to assess gastric motility-related gastric symptoms and levels of ghrelin in patients with SCH compared with those in healthy control subjects and to evaluate the potential effects of L-thyroxine replacement therapy. Methods: Twenty premenopausal women with SCH and 20 age- and body mass index-matched healthy control women were enrolled in the study. The gastroparesis cardinal severity index questionnaire was used to reveal gastrointestinal motility changes, and electrogastrographic activities were measured. Fasting and postprandial ghrelin levels at 30, 60, and 120 minutes were determined during a mixed meal test. All tests were repeated after 6 months when patients were in the euthyroid state. Results: The gastroparesis cardinal severity index score, fasting tachygastria ratio, and postprandial/fasting bradygastria ratio in electrogastrography were higher in patients with SCH compared with control subjects (P = .03, P = .04, and P = .04, respectively). All 3 parameters significantly improved after L-thyroxine replacement therapy (P = .001, P = .005, and P = .02 respectively) reaching levels similar to those of control subjects. Baseline and area under the curve for ghrelin during mixed meal tests did not show a difference between patients with SCH and control subjects and before and after L-thyroxine replacement in SCH. Conclusion: Gastric dysmotility and the resultant upper gastrointestinal symptoms can be observed in SCH, and symptomatology related to dysmotility and parameters appear to be improved with thyroid hormone replacement. Our results also suggest that ghrelin levels in response to a meal are similar between women with SCH and healthy women and that normalization of thyroid function by L-thyroxine does not modulate these levels.WoSScopu