Effects of granulocyte colony-stimulating factor administration time on pain

WOS: 000407091600005PubMed ID: 28766349OBJECTIVE: This study was aimed at evaluating the effect of administration time of granulocyte colony-stimulating factor (G-CSF) on the level of pain related to G-CSF. METHODS: This study was carried out with 48 cancer patients divided into A and B groups. In the first stage of the study, the groups A and B were planned to be administered with G-CSF at 10: 00 and 14: 00, respectively. In the second stage, patients in groups A and B were asked to self-administer filgrastim at 14: 00 and 10: 00, respectively. Patients were also asked to assess their pain level after G-CSF administration for a total of 4 times. RESULTS: According to the findings, the incidence of pain related to G-CSF was 91.7 %. The pain score after G-CSF being administered at 10: 00 was significantly higher compared to administration at 14: 00 in both groups (group A after 4, 8, and 12 hours: p < 0.05; group B after 4 and 8 hours: p < 0.05). CONCLUSIONS: The results of the present study have demonstrated that the pain score related to G-CSF administration at 14:00 p.m. was significantly reduced. Thus, in order to minimize the pain, it will be more beneficial to administer G-CSF at 14: 00 (Tab. 4, Ref. 31). Text in PDF www.elis.sk

Can curcumin modulate allergic rhinitis in rats?

karimkhani, Hadi/0000-0002-4966-1745; Shojaolsadati, Paria/0000-0001-8311-5425WOS: 000391446800006PubMed: 27707425Objectives: This study aimed to explore the effects of curcumin on experimental allergic rhinitis in rats. Methods: Twenty-eight male Wistar albino rats were randomly divided into four groups: a control group; a group in which allergic rhinitis was induced and no treatment given; a group in which allergic rhinitis was induced followed by treatment with azelastine hydrochloride on days 21-28; and a group in which allergic rhinitis was induced followed by treatment with curcumin on days 21-28. Allergy symptoms and histopathological features of the nasal mucosa were examined. Results: The sneezing and nasal congestion scores were higher in the azelastine and curcumin treatment groups than in the control group. Histopathological examination showed focal goblet cell metaplasia on the epithelial surface in the azelastine group. In the curcumin group, there was a decrease in goblet cell metaplasia in the epithelium, decreased inflammatory cell infiltration and vascular proliferation in the lamina propria. Conclusion: Curcumin is an effective treatment for experimentally induced allergic rhinitis in rats.Continuous Education and Scientific Research Association, TurkeyStudy design and planning and manuscript preparation were supported by the Continuous Education and Scientific Research Association, Turkey

Clinical Pharmacology of Endothelin Receptor Antagonists Used in the Treatment of Pulmonary Arterial Hypertension

International audiencePulmonary arterial hypertension (PAH) is a devastating life-threatening disorder characterized by elevated pulmonary vascular resistance leading to elevated pulmonary arterial pressures, right ventricular failure and ultimately death. Vascular endothelial cells mainly produce and secrete endothelin (ET-1) in vessels that lead to a potent and long-lasting vasoconstrictive effect in pulmonary arterial smooth muscle cells. Along with its strong vasoconstrictive action, ET-1 can promote smooth muscle cell proliferation. Thus, ET-1 blockers have attracted attention as an antihypertensive drug and the ET-1 signaling system has paved a new therapeutic avenue for the treatment of PAH. The present chapter outlines not only the current understanding of the pathogenic role played by ET-1 signaling systems in the pathogenesis of PH, but also on the clinical pharmacology of endothelin receptor antagonists (ERA) used in the treatment of PAH