471 research outputs found
Revisiting DETR Pre-training for Object Detection
Motivated by that DETR-based approaches have established new records on COCO
detection and segmentation benchmarks, many recent endeavors show increasing
interest in how to further improve DETR-based approaches by pre-training the
Transformer in a self-supervised manner while keeping the backbone frozen. Some
studies already claimed significant improvements in accuracy. In this paper, we
take a closer look at their experimental methodology and check if their
approaches are still effective on the very recent state-of-the-art such as
-Deformable-DETR. We conduct thorough experiments on COCO object
detection tasks to study the influence of the choice of pre-training datasets,
localization, and classification target generation schemes. Unfortunately, we
find the previous representative self-supervised approach such as DETReg, fails
to boost the performance of the strong DETR-based approaches on full data
regimes. We further analyze the reasons and find that simply combining a more
accurate box predictor and Objects benchmark can significantly improve the
results in follow-up experiments. We demonstrate the effectiveness of our
approach by achieving strong object detection results of AP= on COCO
val set, which surpasses -Deformable-DETR + Swin-L by +.
Last, we generate a series of synthetic pre-training datasets by combining the
very recent image-to-text captioning models (LLaVA) and text-to-image
generative models (SDXL). Notably, pre-training on these synthetic datasets
leads to notable improvements in object detection performance. Looking ahead,
we anticipate substantial advantages through the future expansion of the
synthetic pre-training dataset
Rank-DETR for High Quality Object Detection
Modern detection transformers (DETRs) use a set of object queries to predict
a list of bounding boxes, sort them by their classification confidence scores,
and select the top-ranked predictions as the final detection results for the
given input image. A highly performant object detector requires accurate
ranking for the bounding box predictions. For DETR-based detectors, the
top-ranked bounding boxes suffer from less accurate localization quality due to
the misalignment between classification scores and localization accuracy, thus
impeding the construction of high-quality detectors. In this work, we introduce
a simple and highly performant DETR-based object detector by proposing a series
of rank-oriented designs, combinedly called Rank-DETR. Our key contributions
include: (i) a rank-oriented architecture design that can prompt positive
predictions and suppress the negative ones to ensure lower false positive
rates, as well as (ii) a rank-oriented loss function and matching cost design
that prioritizes predictions of more accurate localization accuracy during
ranking to boost the AP under high IoU thresholds. We apply our method to
improve the recent SOTA methods (e.g., H-DETR and DINO-DETR) and report strong
COCO object detection results when using different backbones such as
ResNet-, Swin-T, and Swin-L, demonstrating the effectiveness of our
approach. Code is available at \url{https://github.com/LeapLabTHU/Rank-DETR}.Comment: NeurIPS 202
A Novel STAP Algorithm for Airborne MIMO Radar Based on Temporally Correlated Multiple Sparse Bayesian Learning
In a heterogeneous environment, to efficiently suppress clutter with only one snapshot, a novel STAP algorithm for multiple-input multiple-output (MIMO) radar based on sparse representation, referred to as MIMOSR-STAP in this paper, is presented. By exploiting the waveform diversity of MIMO radar, each snapshot at the tested range cell can be transformed into multisnapshots for the phased array radar, which can estimate the high-resolution space-time spectrum by using multiple measurement vectors (MMV) technique. The proposed approach is effective in estimating the spectrum by utilizing Temporally Correlated Multiple Sparse Bayesian Learning (TMSBL). In the sequel, the clutter covariance matrix (CCM) and the corresponding adaptive weight vector can be efficiently obtained. MIMOSR-STAP enjoys high accuracy and robustness so that it can achieve better performance of output signal-to-clutter-plus-noise ratio (SCNR) and minimum detectable velocity (MDV) than the single measurement vector sparse representation methods in the literature. Thus, MIMOSR-STAP can deal with badly inhomogeneous clutter scenario more effectively, especially suitable for insufficient independent and identically distributed (IID) samples environment
The relationship between atrial fibrillation and NLRP3 inflammasome: a gut microbiota perspective
Atrial fibrillation (AF) is a common clinical arrhythmia whose pathogenesis has not been fully elucidated, and the inflammatory response plays an important role in the development of AF. The inflammasome is an important component of innate immunity and is involved in a variety of pathophysiologic processes. The NLRP3 inflammasome is by far the best studied and validated inflammasome that recognizes multiple pathogens through pattern recognition receptors of innate immunity and mediates inflammatory responses through activation of Caspase-1. Several studies have shown that NLRP3 inflammasome activation contributes to the onset and development of AF. Ecological dysregulation of the gut microbiota has been associated with the development of AF, and some evidence suggests that gut microbiota components, functional byproducts, or metabolites may induce or exacerbate the development of AF by directly or indirectly modulating the NLRP3 inflammasome. In this review, we report on the interconnection of NLRP3 inflammasomes and gut microbiota and whether this association is related to the onset and persistence of AF. We discuss the potential value of pharmacological and dietary induction in the management of AF in the context of the association between the NLRP3 inflammasome and gut microbiota. It is hoped that this review will lead to new therapeutic targets for the future management of AF
YOLOv6: A Single-Stage Object Detection Framework for Industrial Applications
For years, the YOLO series has been the de facto industry-level standard for
efficient object detection. The YOLO community has prospered overwhelmingly to
enrich its use in a multitude of hardware platforms and abundant scenarios. In
this technical report, we strive to push its limits to the next level, stepping
forward with an unwavering mindset for industry application.
Considering the diverse requirements for speed and accuracy in the real
environment, we extensively examine the up-to-date object detection
advancements either from industry or academia. Specifically, we heavily
assimilate ideas from recent network design, training strategies, testing
techniques, quantization, and optimization methods. On top of this, we
integrate our thoughts and practice to build a suite of deployment-ready
networks at various scales to accommodate diversified use cases. With the
generous permission of YOLO authors, we name it YOLOv6. We also express our
warm welcome to users and contributors for further enhancement. For a glimpse
of performance, our YOLOv6-N hits 35.9% AP on the COCO dataset at a throughput
of 1234 FPS on an NVIDIA Tesla T4 GPU. YOLOv6-S strikes 43.5% AP at 495 FPS,
outperforming other mainstream detectors at the same scale~(YOLOv5-S, YOLOX-S,
and PPYOLOE-S). Our quantized version of YOLOv6-S even brings a new
state-of-the-art 43.3% AP at 869 FPS. Furthermore, YOLOv6-M/L also achieves
better accuracy performance (i.e., 49.5%/52.3%) than other detectors with a
similar inference speed. We carefully conducted experiments to validate the
effectiveness of each component. Our code is made available at
https://github.com/meituan/YOLOv6.Comment: technical repor
Body mass index-associated responses to an ABVD-like regimen in newly-diagnosed patients with Hodgkin lymphoma
Background: The role of body mass index (BMI) in the treatment outcomes of lymphoma patients is controversial. While investigating the efficacy of ABVD-like regimen in Hodgkin lymphoma (HL) patients, we observed that obese patients had poor responses. To better understand this clinical phenomenon, we evaluated the effect of BMI on responses to ABVD-like chemotherapy in HL patients.Methods: This retrospective cohort study evaluated the clinical outcomes of all 67 patients with confirmed HL who were treated at the First Affiliated Hospital of Soochow University from November 2016 to March 2023 with an ABVD-like regimen as first-line chemotherapy. Baseline patient characteristics and clinical outcomes were compared across different BMI categories. The primary end-point was the overall response rate defined as the proportion of the HL patients who achieved complete response or partial response. The additional end-points included progression-free survival and overall survival.Results: The median age of the HL patients was 31 years old. Of the patients, 10.4% were obese, and 17.9% patients were overweight. Interim and end-term response evaluations revealed overall response rates of 98.5% and 83.6%, respectively. The proportion of patients with potential poor prognostic factors (IPS risk factors) did not differ significantly in the responders versus non-responders. However, non-responders had a higher average BMI when compared with responders (p = 0.002). Poor overall response rates in higher BMI patients indeed manifested with shorter progression free survival (p = 0.013). The minimum relative dose of the ABVD-like regimen in the overweight and obese groups was significantly lower than in the normal weight group (p < 0.001).Conclusion: Our analyses show that >80% of newly-diagnosed HL patients responded to the ABVD-like regimen. We find that being obese or overweight at the time of diagnosis correlated with a poorer overall response rate and that BMI was an independent risk factor in HL patients treated with the ABVD-like regimen. Lower doses of ABVD-like regimen contributed to the discrepant findings of responses in the high BMI groups. These findings indicate that newly-diagnosed, obese HL patients receiving an ABVD-like regimen require personalized treatment
Medical Cost Associated with Prediabetes
Abstract In this article, we estimate national health care resource use and medical costs in 2007 associated with prediabetes (PD), defined as either fasting plasma glucose between 100 and 125 or oral glucose tolerance test between 140 and 200. We use Poisson regression with medical claims for an adult population continuously insured between 2004 and 2006 to analyze patterns of health care resource use by PD status. Combining rate ratios that reflect health care use patterns with national PD prevalence rates from the National Health and Nutrition Examination Survey, we calculate etiological fractions to estimate the portion of national health resource use associated with PD. The findings suggest that PD is associated with statistically higher rates of ambulatory visits for hypertension; endocrine, metabolic, and renal complications; and general medical conditions. PD is associated with a slight increase in visit rates for neurological symptoms, peripheral vascular disease, and cardiovascular disease, but the increase is not statistically significant. There is no indication that PD is associated with an increase in emergency visits and inpatient days. Extrapolating these patterns to the 57 million adults with PD in 2007 suggests that national annual medical costs of PD exceed 443 for each adult with PD. PD is associated with excessive use of ambulatory services for comorbidities known to be related to diabetes. Our findings strengthen the business case for lifestyle interventions to prevent diabetes by adding additional economic benefits that potentially can be achieved by preventing or delaying PD. (Population Health Management
Multidifferential study of identified charged hadron distributions in -tagged jets in proton-proton collisions at 13 TeV
Jet fragmentation functions are measured for the first time in proton-proton
collisions for charged pions, kaons, and protons within jets recoiling against
a boson. The charged-hadron distributions are studied longitudinally and
transversely to the jet direction for jets with transverse momentum 20 GeV and in the pseudorapidity range . The
data sample was collected with the LHCb experiment at a center-of-mass energy
of 13 TeV, corresponding to an integrated luminosity of 1.64 fb. Triple
differential distributions as a function of the hadron longitudinal momentum
fraction, hadron transverse momentum, and jet transverse momentum are also
measured for the first time. This helps constrain transverse-momentum-dependent
fragmentation functions. Differences in the shapes and magnitudes of the
measured distributions for the different hadron species provide insights into
the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb
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