Pembuatan Niosom Berbasis Maltodekstrin De 5-10 Dari Pati Singkong (Manihot Utilissima)

Niosomes are non ionic surfactant vesicles that have potential application in the delivery of hydrophobic or amphilic drugs. We developed proniosomes, a dry formulation using a maltodextrin as a carrier coated with non ionic surfactant, which can be used to produce niosomes within a minutes by addition of hot water followed by agitation. A novel method is reported here for rapid preparation of proniosomes with wide range of surfactant loading. Maltodextrin DE 5-10 was hidrolyzed from tapioca starch using Thermamyl L 120 da Novo at 85o C. The result from SEM analyses shown that proniosomes appear very similar to the maltodextrin, but the surface was more smooth. Niosome suspensions which was observed under the optical microscopy and particle size analyzer were evaluated as drug carrier using ibuprofen as a model. The result provide an indication of maltodextrin DE 5-10 from tapioca starch are potentialy carrier in the proniosome preparation which can be used for producing niosomes

Additional file 1: of MBDDiff: an R package designed specifically for processing MBDcap-seq datasets

Supplementary information. Supplementary figures and tables to provide additional analysis results. (PDF 1214 kb

Additional file 3: Figure S3. of A hierarchical model for clustering m6A methylation peaks in MeRIP-seq data

Motifs for Cluster 2 and 3 detected by DREME in human HeLa cells. (PNG 21 kb

Additional file 2: Figure S2. of A hierarchical model for clustering m6A methylation peaks in MeRIP-seq data

Distribution of m6A for different clusters in mRNA and lncRNA in KO-METTL14 human HeLa cells. (PNG 173 kb

Additional file 1: Table S1. of A simple gene set-based method accurately predicts the synergy of drug pairs

List of co-enriched gene sets for all drug combinations in the DREAM dataset. (XLSX 35 kb

Additional file 1: Figure S1. of A hierarchical model for clustering m6A methylation peaks in MeRIP-seq data

Distribution of m6A for different clusters in mRNA and lncRNA in KO-FTO mouse midbrain cells. A. The distribution of m6A peaks for different clusters in mRNA. B. The distribution of m6A peaks for different clusters in lncRNA. (PNG 114 kb

Additional file 2: Table S2. of A simple gene set-based method accurately predicts the synergy of drug pairs

Prediction of all 1,038,710 drug combinations in the CMap dataset. (XLSX 28927 kb

Additional file 4: Table S2. of Differential correlation analysis of glioblastoma reveals immune ceRNA interactions predictive of patient survival

Top overrepresented ceRNAs in the core ceRNA network. (PDF 67 kb

Table_1_Gastrointestinal Talaromyces marneffei infection in a patient with AIDS: A case report and systematic review.docx

Talaromyces marneffei is a thermally dimorphic fungus that affects multiple organs and frequently invades immunocompromised individuals. However, only a few studies have reported the presence of intestinal infection associated with T. marneffei. Herein, we reported a case of intestinal T. marneffei infection in a man who complained of a 1-month history of intermittent fever, abdominal pain, and diarrhea. The result of the human immunodeficiency virus antibody test was positive. Periodic acid-Schiff and Gomorrah’s methylamine silver staining of the intestinal biopsy tissue revealed T. marneffei infection. Fortunately, the patient’s symptoms rapidly resolved with prompt antifungal treatment. In addition, we summarized and described the clinical characteristics, management, and outcomes of patients with intestinal T. marneffei infection. A total of 29 patients were identified, the majority of whom (65.52%) were comorbid with acquired immunodeficiency syndrome. The main clinical features included anemia, fever, abdominal pain, diarrhea, weight loss, and lymphadenopathy. The transverse and descending colon, ileocecum, and ascending colon were the most common sites of lesions. A considerable number of patients (31.03%) developed intestinal obstruction, intestinal perforation, and gastrointestinal bleeding. Of the 29 patients, six underwent surgery, 23 survived successfully with antifungal treatment, five died of T. marneffei infection, and one died of unknown causes. T. marneffei intestinal infection should be considered when immunodeficient patients in endemic areas present with non-specific symptoms, such as fever, abdominal pain, and diarrhea. Appropriate and timely endoscopy avoids delays in diagnosis. Early aggressive antifungal therapy improves the clinical outcomes of patients.</p

UCHL1 knockdown-associated transcriptome.

<p>UCHL1 knockdown-associated transcriptome.</p