Effects of Condylar Elastic Properties to Temporomandibular Joint Stress

Mandibular condyle plays an important role in the growth and reconstruction of the temporomandibular joint (TMJ). We aimed to obtain orthotropic elastic parameters of the condyle using a continuous-wave ultrasonic technique and to observe the effects of condylar elastic parameters on stress distribution of the TMJ using finite element analysis (FEA). Using the ultrasonic technique, all nine elastic parameters were obtained, which showed that the mandibular condyle was orthotropic. With the condyle defined as orthotropic, the occlusal stress was transferred fluently and uniformly from the mandible to the TMJ. The stress distribution in the isotropic model showed stepped variation among different anatomical structures with higher stress values in the cartilage and condyle than in the orthotropic model. We conclude that anisotropy has subtle yet significant effects on stress distribution of the TMJ and could improve the reality of simulations

Secreted glucose regulated protein78 ameliorates DSS-induced mouse colitis

The secreted form of 78-kDa glucose-regulated protein (sGRP78) has been widely reported for its property in aiding resolution of inflammatory. However, little is known on its potential in the treatment of colitis. To investigate the expression pattern and functional outcome of GRP78 in ulcerative colitis, its expression was measured in human and murine colitis samples. It was found that GRP78 was spontaneously secreted to a high level in gut, which is a physiological site of immune tolerance. During the active phase of DSS-induced colitis, the sGRP78 level was significantly reduced but rebounded quickly during resolving phase, making it a potential candidate for the treatment of colitis. In the following experiments, the administration of sGRP78 was proved to decrease susceptibility to experimental colitis, as indicated by an overall improvement of intestinal symptoms, restoration of TJ integrity, decreased infiltration of immune cells and impaired production of inflammatory cytokines. And specific cleavage of endogenous sGRP78 could aggravate DSS colitis. Adoptive transfer of sGRP78-conditioned BMDMs reduced inflammation in the gut. We linked sGRP78 treatment with altered macrophage biology and skewed macrophage polarization by inhibiting the TLR4-dependent MAP-kinases and NF-κB pathways. Based on these studies, as a naturally occurring immunomodulatory molecule, sGRP78 might be an attractive novel therapeutic agent for acute intestinal inflammation

A neural network for solving a convex quadratic bilevel programming problem

AbstractA neural network is proposed for solving a convex quadratic bilevel programming problem. Based on Lyapunov and LaSalle theories, we prove strictly an important theoretical result that, for an arbitrary initial point, the trajectory of the proposed network does converge to the equilibrium, which corresponds to the optimal solution of a convex quadratic bilevel programming problem. Numerical simulation results show that the proposed neural network is feasible and efficient for a convex quadratic bilevel programming problem

A penalty function method for solving inverse optimal value problem

AbstractIn order to consider the inverse optimal value problem under more general conditions, we transform the inverse optimal value problem into a corresponding nonlinear bilevel programming problem equivalently. Using the Kuhn–Tucker optimality condition of the lower level problem, we transform the nonlinear bilevel programming into a normal nonlinear programming. The complementary and slackness condition of the lower level problem is appended to the upper level objective with a penalty. Then we give via an exact penalty method an existence theorem of solutions and propose an algorithm for the inverse optimal value problem, also analysis the convergence of the proposed algorithm. The numerical result shows that the algorithm can solve a wider class of inverse optimal value problem

Chiral Dual-Core Photonic Crystal Fiber for an Efficient Circular Polarization Beam Splitter

As a function of a circular polarization beam splitter (CPBS), combining a linear polarization beam splitter with a quarter-wave plate results in a polarization error in a circular polarization fiber-optic circuit. To relieve the error, chiral dual-core photonic crystal fiber (DC-PCF) is investigated as a kind of an efficient circular polarization beam splitter by using the chiral plane-wave expansion (PWE) method. On the basis of the competitive effect in polarization and coupling length between the circular asymmetry of the structure and the chirality of the medium, the effects of the structure and the chirality are analyzed. The numerical results demonstrate that a CPBS needs the weak circular asymmetry in its structure and a relatively stronger chirality of the medium. Then, a kind of CPBS based on chiral DC-PCF is designed with weaker chirality, with a central wavelength of 1.55 μm. The simulation shows the superior performance of having a shorter coupling length and a higher extinction ratio. Furthermore, the dual-wavelength of 1.55 μm and 1.30 μm with left-circular polarization can further be separated by the corresponding chiral DC-PCF. The results show promising applications for the circular polarized multiplexer/demultiplexer in fiber laser communication systems

Knowledge-map analysis of bladder cancer immunotherapy

ABSTRACTThis study aimed to conduct a bibliometric analysis in the field of bladder cancer (BC) immunotherapy, and explore the research trends, hotspots and frontiers from 2000 to 2022. VOSviewer software was used to analyze the collaborative relationships between authors, institutions, countries/regions, and journals through citation, co-authorship, and co-citation analysis, to identify research hotspots and frontiers in this field. Researchers based in the United States of America have published a total of 627 papers with 27,308 citations. Indeed, the USA ranked first among the top 10 most active countries and showed the most extensive collaboration with other countries. The University of Texas MD Anderson CANC CTR has published 58 articles, making it the top most institution in terms of published articles and active collaborative research. Kamat AM and Lamm DL were the most active and co-cited authors with 28 papers and 980 co-citations, respectively. Chang Yuan and Xu le were the most active collaborative authors with a total link strength of 195. The J UROLOGY was the most active and frequently co-cited journal, with 100 papers and 6,668 co-citations. Studies of BC immunotherapy can be broadly classified into three categories: “basic research”, “clinical trial”, and “prognosis”. Our findings provide an overview of the research priorities and future directions of BC immunotherapy. Tumor microenvironment and immune checkpoint inhibitors (ICIs) of BC, as well as the combination of ICIs with other drugs, may become the main direction of future research