A comparison about the inhibitory effect of curcunmin and Avastin on the rat corneal neovascularization

AIM: To compare the inhibitory effect of curcunmin and Avastin on the rat corneal neovascularization(CNV), and approach the mechanism of the curcunmin's inhibition. METHODS: CNV was established in thirty SD rats by alkaline burning. Rats were divided equally to group A and group B at random. In group A, right eyes were experimental group A1, treated by 40μmol/L curcunmin solution, and left eyes were control group A2, treated by 0.09% sodium chloride. In group B, right eyes were experimental group group B1, treated by 5g/L avastin, and left eyes were control group B2, treated by 0.09% sodium chloride. Cornea and aqueous humor were collected by time spot. The capillary vessels were study, and the expressions of VEGF were detected by Enzyme-Linked immunosorbnent Assay(ELISA). RESULTS: No toxic effects of the drugs were found. The capillary vessels in experimental group were less than those of control group(P<0.01). No statistical different of the capillary vessels between two drugs were found. The expressions of VEGF in experimental group were less than those in control group(P<0.01). The expressions of VEGF in B1 group were less than in group A1. CONCLUSION: The inhibitory effect to CNV of curcunmin and avastin have no statistical different in the experiment, but curcunmin has the less inhibitory effect to the expressions of VEGF than avastin. Curcunmin may have other mechanism in the inhibitory action on CNV

Di-μ-sulfato-bis­[diaqua­(1H-imidazo[4,5-f][1,10]phenanthroline)nickel(II)] dihydrate

In the title compound, [Ni2(SO4)2(C13H8N4)2(H2O)4]·2H2O, the complete dimeric complex is generated by an inversion center. The NiII atoms are octa­hedrally coordinated by two N atoms from one 1H-imidazo[4,5-f][1,10]phenanthroline (IP) ligand and two O atoms from two adjacent sulfate ions forming the equatorial plane, with two coordinated water mol­ecules in the axial sites. Both of the sulfate ions act as bidentate-bridging ligands connecting the two NiII ions, thus generating a binuclear complex. In the crystal structure, O—H⋯O and O—H⋯N hydrogen bonds involving the coordinated and uncoordinated water mol­ecules and N—H⋯O links lead to the formation of a two-dimensional sheet structure developing parallel to (010). Weak π–π stacking inter­actions [centroid–centroid separation = 3.613 (2) Å] between the IP ligands also occur

High hepatitis B virus load is associated with hepatocellular carcinomas development in Chinese chronic hepatitis B patients: a case control study

<p>Abstract</p> <p>Background</p> <p>Persistent hepatitis B virus (HBV) infection is a risk factor for hepatocellular carcinoma (HCC) development. This study aimed to clarify whether the high HBV DNA level is associated with HCC development by comparing HBV DNA levels between HBV infected patients with and without HCC.</p> <p>Results</p> <p>There were 78 male and 12 female patients in each group and there was no statistical difference between these two group patients' average ages. The HBV DNA level in the HCC patients was 4.73 ± 1.71 Log₁₀IU/ml while 3.90 ± 2.01 Log₁₀IU/ml in non-HCC patients (<it>P </it>< 0.01). The HBeAg positive rate was 42.2% (38/90) in the HCC group while 13.3% (12/90) in the non-HCC group (<it>P </it>< 0.001). Compared with patients with HBV DNA level of < 3 Log₁₀IU/ml, the patients with level of 3 to < 4, 4 to < 5, 5 to < 6, or ≥ 6 Log₁₀IU/ml had the odds ratio for HCC of 1.380 (95% CI, 0.544-3.499), 3.671 (95% CI, 1.363-9.886), 5.303 (95% CI, 1.847-15.277) or 3.030 (95% CI, 1.143-8.036), respectively.</p> <p>Conclusions</p> <p>HBV-related HCC patients had higher HBV DNA level than non-HCC counterparts. Our findings imply that active HBV replication is associated with the HCC development.</p

INFLUENCE OF INTRACRANIAL PRESSURE ON THE LAMINA CRIBROSA

ABSTRACT Glaucoma is an eye disease related with vision field loss. Although previous study has investigated the influence of intraocular pressure (IOP) on the glaucoma damage to the lamina cribrosa (LC), the intracranial pressure&apos;s (ICP) effect on the LC has never been elucidated. The goal of this work is to determine the effect of ICP on the LC

Central gas entropy excess as a direct evidence for AGN feedback in galaxy groups and clusters

By analyzing Chandra X-ray data of a sample of 21 galaxy groups and 19 galaxy clusters, we find that in 31 sample systems there exists a significant central ($R^{<}_{\sim} 10h_{71}^{-1}$ kpc) gas entropy excess ($\Delta K_{0}$), which corresponds to $\simeq 0.1-0.5$ keV per gas particle, beyond the power-law model that best fits the radial entropy profile of outer regions. We also find a distinct correlation between the central entropy excess $\Delta K_{0}$ and $K$-band luminosity $L_{K}$ of the central dominating galaxies (CDGs), which is scaled as $\Delta K_{0} \propto L_{K}^{1.6\pm0.4}$, where $L_{K}$ is tightly associated with the mass of the supermassive black hole hosted in the CDG. In fact, if an effective mass-to-energy conversion-efficiency of 0.02 is assumed for the accretion process, the cumulative AGN feedback $E^{\rm AGN}_{\rm feedback} \simeq \eta M_{\rm BH}c^{2}$ yields an extra heating of $\simeq 0.5-17.0$ keV per particle, which is sufficient to explain the central entropy excess. In most cases the AGN contribution can compensate the radiative loss of the X-ray gas within the cooling radius ($\simeq 0.002-2.2$ keV per particle), and apparently exceeds the energy required to deviate the scaling relations from the self-similar predictions ($\simeq 0.2-1.0$ keV per particle). In contrast to the AGN feedback, the extra heating provided by supernova explosions accounts for $\simeq 0.01-0.08$ keV per particle in groups and is almost negligible in clusters. Therefore, the observed correlation between $\Delta K_{0}$ and $L_{K}$ can be considered as a direct evidence for AGN feedback in galaxy groups and clusters.Comment: 14 pages, 3 figures, accepted by RA

Clinical value of abnormal MRI findings in patients with unilateral sudden sensorineural hearing loss

PURPOSEWe aimed to determine the relationship of abnormal labyrinthine signals on heavily T2-weighted three-dimensional fluid-attenuated inversion recovery imaging (HF sequence) with hearing impairment and prognosis in patients with sudden sensorineural hearing loss (SSNHL).METHODSPatients with unilateral SSNHL underwent magnetic resonance imaging, including pre-contrast HF sequences and post-contrast HF sequences with a 4-hour scan delay after intravenous gadolinium injection. We measured the signal intensity ratio (SIR) of the vestibule and cochlea relative to the cerebellar medulla on post-contrast HF sequences, and analyzed the relationship of SIR with hearing impairment and prognosis.RESULTSOf 61 patients, 23 (37.7%) showed signal abnormalities on post-contrast HF sequences. Initial hearing loss and hearing recovery were worse in the HF+ group than in the HF- group (P < 0.05). Profound hearing loss was more common in the HF+ group (52.2% vs. 23.7%), while moderate hearing loss was more common in the HF- group (18.4% vs. 0.0%; P < 0.05 for both). The rate of partial recovery was higher in the HF- group (42.1%) than in the HF+ group (13.0%; P < 0.05). The SIRs of the vestibule and cochlea were positively correlated with the severity of hearing loss and hearing recovery, with higher SIRs indicating more severe hearing loss and poor recovery.CONCLUSIONLabyrinthine signal abnormalities were found on post-contrast HF sequences in 37.7% of patients with SSNHL. These abnormalities were found only in patients with severe-to-profound hearing loss. Increased SIR indicated more severe hearing loss and poor prognosis

High remission and low relapse with prolonged intensive DMARD therapy in rheumatoid arthritis (PRINT): A multicenter randomized clinical trial

Objectives: To determine whether prolonged intensive disease-modifying antirheumatic drug (DMARD) treatment (PRINT) leads to high remission and low relapse rates in patients with severe rheumatoid arthritis (RA). Methods: In this multicenter, randomized and parallel treatment trial, 346 patients with active RA (disease activity score (28 joints) [DAS28] (erythrocyte sedimentation rate [ESR]) &gt; 5.1) were enrolled from 9 centers. In phase 1, patients received intensive treatment with methotrexate, leflunomide, and hydroxychloroquine, up to 36 weeks, until remission (DAS28 ≤ 2.6) or a low disease activity (2.6 &#60; DAS28 ≤ 3.2) was achieved. In phase 2, patients achieving remission or low disease activity were followed up with randomization to 1 of 2 step-down protocols: leflunomide plus hydroxychloroquine combination or leflunomide monotherapy. The primary endpoints were good European League Against Rheumatism (EULAR) response (DAS28 (ESR) &#60; 3.2 and a decrease of DAS28 by at least 1.2) during the intensive treatment and the disease state retention rate during step-down maintenance treatment. Predictors of a good EULAR response in the intensive treatment period and disease flare in the maintenance period were sought. Results: A good EULAR response was achieved in 18.7%, 36.9%, and 54.1% of patients at 12, 24, and 36 weeks, respectively. By 36 weeks, 75.4% of patients achieved good and moderate EULAR responses. Compared with those achieving low disease activity and a high health assessment questionnaire (HAQ &gt; 0.5), patients achieving remission (DAS28 ≤ 2.6) and low HAQ (≤ 0.5) had a significantly higher retention rate when tapering the DMARDs treatment (P = 0.046 and P = 0.01, respectively). There was no advantage on tapering to combination rather than monotherapy. Conclusions: Remission was achieved in a proportion of patients with RA receiving prolonged intensive DMARD therapy. Low disease activity at the start of disease taper leads to less subsequent flares. Leflunomide is a good maintenance treatment as single treatment