Influence of Spirocarbone and Derivates of Pyrimidineones on Separate Components of the Oxygen – Transport of blood in vitrol

Rechytskyi, О. Influence of Spirocarbone and Derivates of Pyrimidineones on Separate Components of the Oxygen – Transport of blood in vitrol VII Parnas Conference on Biochemistry and Molecular biology / L. Starykovych, K. Dudok, M. Starykovych, O. Rechytskyi, B. Yeresko, N. Sybirna // Yalta, Crimea, Ukraine, 3-7 October, 2009 The Ukrainian Biochemical Journal. – 2009. – V. 81. – № 4. – Р. 258

Influence of spirocarbone and derivates of pyrrolo pyrimidinediones of survival of leukemia cells

Influence of spirocarbone and derivates of pyrrolopyrimidinediones (1,6-dimethyl-4-phenyl-1,2,3,4,5,7-hexahydropyrolo-[3,4-d]-pyrimidindione-2,5(1Н), and 1,6-dimethyl-4-(2-threefluoromethylphenyl)-1,2,3,4,5,7-hexahydropyrrolo-[3,4-d]-pyrimidinedione-2,5(1Н) on the leukemia cells of L1210 and CEM-T4 lines of mouse and human, res­pectively was studied. Cytotoxic effect of spirocarbone towards L1210 cells accompa­nied by apoptotic fragmen­tation of nuclear DNA

Influence of spirocarbone and derivates of pyrrolopyrimidinedions on phisical and chemical properties of the hemoglobin ligand forms of blood in vitro

The effect of heterocyclic substance spirocarbon and pyrrolopyrimidinedione derivatives was studied on the hemoglobin ligand forms dynamics (RHb, HbO2, HbCO, SHb, MetHb), its basic stability, methemoglobin peroxidase activity and spectrophotometric characteristics of CNMetHb-Coomassi G-250 in the healthy donors’ blood. It was shown that spirocarbon causes a slight HbO2 decrease. In the experiments with pyrrolopyrimidindion derivatives the everage HbO2 values are in the range of control. There was carried out an analysis of HbO2, MetHb, CNMetHb electron spectra and the electron spectra of the complexes CNMetHb-Coomassi G-250. It was testified that spirocarbon causes a certain increase of basic stable hemoglobin and decrease of peroxydase activity. The pyrrolopyrimidinedione derivatives result in increasing of methemoglobin peroxydase activity in the tested samples

Development of the GRAiNITA prototype with ZnWO<inf>4</inf> and BGO crystal grains

International audienceWe will present the development of two medium-size prototypes of GRAiNITA, a next-generation shashlik calorimeter, based on the use of ZnWO4and BGO crystal grains, respectively, soaked in a high-density and high-refractive index liquid. As in the LiquidO detection technique[1], due to the presence of the grains, the scintillation light remains stochastically confined in the area of production; for this reason, it can be collected and transferred towards the photodetectors by the use of wavelength shifting fibers evenly distributed in the detection volume, similarly as in a conventional shashlik calorimeter.GRAiNITA represents a very appealing electromagnetic calorimeter candidate for high energy physics experiments for future electron-positron colliders. Indeed, due to the extreme fine sampling, GRAiNITA has the potential to reach a photon energy resolution of R~2%/sqrt(E) [2], thus increasing the precision of flavor physics with rare decays to photons or neutral pions. In this communication, we will present the outcomes of the study that led us to the choice of the best suited fibers for ZnWO4and BGO, respectively, and we will present the effect observed on the light propagation, when adding isopropanol in the detection volume (as a first approximation of future liquids), to fill the space between the crystal grains. Finally, we will discuss the development and characterization of the prototypes, presenting either the mechanical and the electronic design

Development of the GRAiNITA prototype with ZnWO<inf>4</inf> and BGO crystal grains

International audienceWe will present the development of two medium-size prototypes of GRAiNITA, a next-generation shashlik calorimeter, based on the use of ZnWO4and BGO crystal grains, respectively, soaked in a high-density and high-refractive index liquid. As in the LiquidO detection technique[1], due to the presence of the grains, the scintillation light remains stochastically confined in the area of production; for this reason, it can be collected and transferred towards the photodetectors by the use of wavelength shifting fibers evenly distributed in the detection volume, similarly as in a conventional shashlik calorimeter.GRAiNITA represents a very appealing electromagnetic calorimeter candidate for high energy physics experiments for future electron-positron colliders. Indeed, due to the extreme fine sampling, GRAiNITA has the potential to reach a photon energy resolution of R~2%/sqrt(E) [2], thus increasing the precision of flavor physics with rare decays to photons or neutral pions. In this communication, we will present the outcomes of the study that led us to the choice of the best suited fibers for ZnWO4and BGO, respectively, and we will present the effect observed on the light propagation, when adding isopropanol in the detection volume (as a first approximation of future liquids), to fill the space between the crystal grains. Finally, we will discuss the development and characterization of the prototypes, presenting either the mechanical and the electronic design

First characterization of a novel grain calorimeter: the GRAiNITA prototype

International audienceA novel type of calorimeter based on grains of inorganicscintillating crystal readout by wave length shifting fibers isproposed. The concept and main features as well as the prototypedesign are introduced and the first results obtained using cosmicrays are presented. The number of photo-electrons generated bycosmic rays muons in the prototype detector is estimated to be ofthe order of 10000 photo-electrons per GeV, validating the conceptof this next-generation shashlik calorimeter

The CCube reconstruction algorithm for the SoLid experiment

International audienceThe SoLid experiment is a very-short-baseline experiment aimed at searching for nuclear reactor-produced active to sterile antineutrino oscillations. The detection principle is based on the pairing of two types of solid scintillators: polyvinyl toluene and $^6$LiF:ZnS(Ag), which is a new technology used in this field of Physics. In addition to good neutron-gamma discrimination, this setup allows the detector to be highly segmented (the basic detection unit is a 5 cm side cube). High segmentation provides numerous advantages, including the precise location of Inverse Beta Decay (IBD) products, the derivation of the considerate antineutrino energy estimator, and a powerful background reduction tool based on the topological signature of the signal. Finally, the system is read out by a network of wavelength-shifting fibres coupled to a photodetector (MPPC). This paper describes the design of the reconstruction algorithm that allows maximum use of the granularity of the detector. The goal of the algorithm is to convert the output of the optical-fibre readout to the list of the detection units from which it originated. This paper provides a performance comparison for three methods and concludes with a choice of the baseline approach for the experiment

The CCube reconstruction algorithm for the SoLid experiment

International audienceThe SoLid experiment is a very-short-baseline experiment aimed at searching for nuclear reactor-produced active to sterile antineutrino oscillations. The detection principle is based on the pairing of two types of solid scintillators: polyvinyl toluene and $^6$LiF:ZnS(Ag), which is a new technology used in this field of Physics. In addition to good neutron-gamma discrimination, this setup allows the detector to be highly segmented (the basic detection unit is a 5 cm side cube). High segmentation provides numerous advantages, including the precise location of Inverse Beta Decay (IBD) products, the derivation of the considerate antineutrino energy estimator, and a powerful background reduction tool based on the topological signature of the signal. Finally, the system is read out by a network of wavelength-shifting fibres coupled to a photodetector (MPPC). This paper describes the design of the reconstruction algorithm that allows maximum use of the granularity of the detector. The goal of the algorithm is to convert the output of the optical-fibre readout to the list of the detection units from which it originated. This paper provides a performance comparison for three methods and concludes with a choice of the baseline approach for the experiment

The CCube reconstruction algorithm for the SoLid experiment

International audienceThe SoLid experiment is a very-short-baseline experiment aimed at searching for nuclear reactor-produced active to sterile antineutrino oscillations. The detection principle is based on the pairing of two types of solid scintillators: polyvinyl toluene and $^6$LiF:ZnS(Ag), which is a new technology used in this field of Physics. In addition to good neutron-gamma discrimination, this setup allows the detector to be highly segmented (the basic detection unit is a 5 cm side cube). High segmentation provides numerous advantages, including the precise location of Inverse Beta Decay (IBD) products, the derivation of the considerate antineutrino energy estimator, and a powerful background reduction tool based on the topological signature of the signal. Finally, the system is read out by a network of wavelength-shifting fibres coupled to a photodetector (MPPC). This paper describes the design of the reconstruction algorithm that allows maximum use of the granularity of the detector. The goal of the algorithm is to convert the output of the optical-fibre readout to the list of the detection units from which it originated. This paper provides a performance comparison for three methods and concludes with a choice of the baseline approach for the experiment