141 research outputs found
Minor planet 1566 Icarus: Asteroid or comet?
By employing a cometary nongravitational force model, based on the outgassing of a water ice nucleus, the orbital fits to the optical and radar astrometric data are improved for both Apollo and Icarus. A reliable value for the magnitude of these nongravitational effects can be determined for Icarus, but not Apollo. Because Icarus is less than a kilometer in extent, the small amount of outgassing required to explain its anomalous orbital behavior would probably not be sufficient to create an easily visible coma. While these results do not prove that 1566 Icarus is an active comet masquerading as an asteroid, this object certainly deserves future scrutiny to determine its true identity. A near-Earth asteroid showing cometary activity must represent only the tip of a much larger cometary iceburg. For such an object whose aphelion is well inside Jupiter's orbit, the time scale for losing its volatiles is much shorter than the time scale for evolving out of the inner solar system. Thus, for each active member of the near-Earth asteroid population, there must be many more that are temporarily or permanently inactive
Comet and asteroid dynamics
In order to provide the ground-based observing community and NASA flight projects with accurate comet and asteroids ephemerides, improvements are being made to the existing dynamic models and new data type are being investigated. For active comets, non-gravitational forces must be taken into account; these forces are assumed due to the rocket-like thrusting of outgassing cometary ices
Comet and asteroid dynamics
In order to provide observers with accurate ephemerides of comets and asteroids, up-to-date astrometric positions must be used to improve the existing orbits. For active comets, nongravitational forces must be taken into account; these forces are assumed due to the rocket-like effect of outgassing cometary ices and are used to characterize the volatility and rotation properties of icy cometary nuclei. In an effort to improve ephemeris accuracies, the benefits of a new nongravitational force model for comets as well as new radar data types are being investigated. The first successful attempts to improve the orbits of close Earth approaching asteroids using radar data have been completed for asteroids 1982XB and 1986JK. The radar Doppler measurements of 1982XB, made on Dec. 5-6, 1987, were represented to less than 0.1 Hz while the Doppler observations of 1986Jk, made on May 28 - June 1, 1986, were represented to within a few Hz for each of the 11 measurements. Last minute orbit updates for asteroid 324 Bamberga allowed a successful stellar occultation prediction to be made on Dec. 8, 1987. A new paradigm for the cometary nongravitational force model has been successfully tested on a few comets. This new model allows the water vaporization curve to peak on either side of perihelion, thus introducing a nongravitational force via an asymmetric radial force, rather than through a symmetric transverse effect that the old model requires
Surveys, Astrometric Follow-up & Population Statistics
Asteroid surveys are the backbone of asteroid science, and with this in mind
we begin with a broad review of the impact of asteroid surveys on our field. We
then provide a brief history of asteroid discoveries so as to place
contemporary and future surveys in perspective. Surveys in the United States
have discovered the vast majority of the asteroids and this dominance has been
consolidated since the publication of Asteroids III. Our descriptions of the
asteroid surveys that have been operational since that time are focussed upon
those that have contributed the vast majority of asteroid observations and
discoveries. We also provide some insight into upcoming next-generation surveys
that are sure to alter our understanding of the small bodies in the inner solar
system and provide evidence to untangle their complicated dynamical and
physical histories. The Minor Planet Center, the nerve center of the asteroid
discovery effort, has improved its operations significantly in the past decade
so that it can manage the increasing discovery rate, and ensure that it is
well-placed to handle the data rates expected in the next decade. We also
consider the difficulties associated with astrometric follow-up of newly
identified objects. It seems clear that both of these efforts must operate in
new modes in order to keep pace with expected discovery rates of
next-generation ground- and space-based surveys.Comment: Chapter to appear in the book ASTEROIDS IV, (University of Arizona
Press) Space Science Series, edited by P. Michel, F. DeMeo and W. Bottk
Intrathecal Administration of AYX2 DNA Decoy Produces a Long-Term Pain Treatment in Rat Models of Chronic Pain by Inhibiting the KLF6, KLF9, and KLF15 Transcription Factors
Background: Nociception is maintained by genome-wide regulation of transcription in the dorsal root ganglia—spinal cord network. Hence, transcription factors constitute a promising class of targets for breakthrough pharmacological interventions to treat chronic pain. DNA decoys are oligonucleotides and specific inhibitors of transcription factor activities. A methodological series of in vivo–in vitro screening cycles was performed with decoy/transcription factor couples to identify targets capable of producing a robust and long-lasting inhibition of established chronic pain. Decoys were injected intrathecally and their efficacy was tested in the spared nerve injury and chronic constriction injury models of chronic pain in rats using repetitive von Frey testing.
Results: Results demonstrated that a one-time administration of decoys binding to the Kruppel-like transcription factors (KLFs) 6, 9, and 15 produces a significant and weeks–month long reduction in mechanical hypersensitivity compared to controls. In the spared nerve injury model, decoy efficacy was correlated to its capacity to bind KLF15 and KLF9 at a specific ratio, while in the chronic constriction injury model, efficacy was correlated to the combined binding capacity to KLF6 and KLF9. AYX2, an 18-bp DNA decoy binding KLF6, KLF9, and KLF15, was optimized for clinical development, and it demonstrated significant efficacy in these models.
Conclusions: These data highlight KLF6, KLF9, and KLF15 as transcription factors required for the maintenance of chronic pain and illustrate the potential therapeutic benefits of AYX2 for the treatment of chronic pain
Pharmacology, Pharmacokinetics, and Metabolism of the DNA-Decoy AYX1 for the Prevention of Acute and Chronic Post-Surgical Pain
Background: AYX1 is an unmodified DNA-decoy designed to reduce acute post-surgical pain and its chronification with a single intrathecal dose at the time of surgery. AYX1 inhibits the transcription factor early growth response protein 1, which is transiently induced at the time of injury and triggers gene regulation in the dorsal root ganglia and spinal cord that leads to long-term sensitization and pain. This work characterizes the AYX1 dose-response profile in rats and the link to AYX1 pharmacokinetics and metabolism in the cerebrospinal fluid, dorsal root ganglia, and spinal cord.
Results: The effects of ascending dose-levels of AYX1 on mechanical hypersensitivity were measured in the spared nerve injury model of chronic pain and in a plantar incision model of acute post-surgical pain. AYX1 dose-response profile shows that efficacy rapidly increases from a minimum effective dose of ∼ 0.5 mg to a peak maximum effective dose of ∼ 1 mg. With further dose escalation, the efficacy paradoxically appears to decrease by ∼ 30% and then returns to full efficacy at the maximum feasible dose of ∼ 4 mg. The reduction of efficacy is associated to doses triggering a near-saturation of AYX1 metabolism by nucleases in the cerebrospinal fluid and a paradoxical reduction of AYX1 exposure during the period of early growth response protein 1 induction. This effect is overcome at higher doses that compensate for the effect of metabolism.
Discussion: AYX1 is a competitive antagonist of early growth response protein 1, which is consistent with the overall increased efficacy observed as dose-levels initially escalate. Chemically, AYX1 is unprotected against degradation by nucleases. The sensitivity to nucleases is reflected in a paradoxical reduction of efficacy in the dose-response curve.
Conclusions: These findings point to the importance of the nuclease environment of the cerebrospinal fluid to the research and development of AYX1 and other intrathecal nucleotide-based therapeutics
Multidifferential study of identified charged hadron distributions in -tagged jets in proton-proton collisions at 13 TeV
Jet fragmentation functions are measured for the first time in proton-proton
collisions for charged pions, kaons, and protons within jets recoiling against
a boson. The charged-hadron distributions are studied longitudinally and
transversely to the jet direction for jets with transverse momentum 20 GeV and in the pseudorapidity range . The
data sample was collected with the LHCb experiment at a center-of-mass energy
of 13 TeV, corresponding to an integrated luminosity of 1.64 fb. Triple
differential distributions as a function of the hadron longitudinal momentum
fraction, hadron transverse momentum, and jet transverse momentum are also
measured for the first time. This helps constrain transverse-momentum-dependent
fragmentation functions. Differences in the shapes and magnitudes of the
measured distributions for the different hadron species provide insights into
the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb
public pages
Study of the decay
The decay is studied
in proton-proton collisions at a center-of-mass energy of TeV
using data corresponding to an integrated luminosity of 5
collected by the LHCb experiment. In the system, the
state observed at the BaBar and Belle experiments is
resolved into two narrower states, and ,
whose masses and widths are measured to be where the first uncertainties are statistical and the second
systematic. The results are consistent with a previous LHCb measurement using a
prompt sample. Evidence of a new
state is found with a local significance of , whose mass and width
are measured to be and , respectively. In addition, evidence of a new decay mode
is found with a significance of
. The relative branching fraction of with respect to the
decay is measured to be , where the first
uncertainty is statistical, the second systematic and the third originates from
the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb
public pages
Measurement of the ratios of branching fractions and
The ratios of branching fractions
and are measured, assuming isospin symmetry, using a
sample of proton-proton collision data corresponding to 3.0 fb of
integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The
tau lepton is identified in the decay mode
. The measured values are
and
, where the first uncertainty is
statistical and the second is systematic. The correlation between these
measurements is . Results are consistent with the current average
of these quantities and are at a combined 1.9 standard deviations from the
predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb
public pages
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