10 research outputs found
A New Approach to Disability Prevention in the Medicare Population: Implications and Strategies for Implementation
Medicare is the federally-administered health insurance program that serves individuals over 65 who meet eligibility requirements. The solvency ofthis program has become a topic of much debate within health policy circles. As the number of Medicare beneficiaries is expected to increase significantly during the coming decades, emphasis has been placed on cost containment and quality improvement. A significant number of elders reports functional and cognitive impairments. Furthermore, the vast majority of beneficiaries reports at least one chronic illness. Chronic illness and functional impairment both increase the risk for future disability. Functional decline and disability are directly responsible for short- and long-term health care costs, and certain health and lifestyle characteristics such as heart disease, diabetes, smoking, body mass index, and physical activity have been shown to predict future disability. Thus, Medicare must transition from an acute care focus to alternative methods of chronic care management, disease and disability prevention. Community-based interventions to promote lifestyle modifications and chronic disease management have been evaluated and proven effective in decreasing disability and health resource use. These community-based efforts will need to be developed in conjunction with office-based chronic care management strategies. This paper reviews effective community-based interventions in order to recommend a new model of community-based health promotion for Medicare beneficiaries. In order for this type of model to be successful, Medicare will need to change its reimbursement policies that currently promote office-based, procedurallyoriented care to policies that enhance a team approach to disability prevention and health promotion among seniors.Master of Public Healt
Adverse Childhood Experiences and Adult Smoking, Nebraska, 2011
Introduction Smoking is a public health risk; the prevalence of smoking among adults in Nebraska is 18-4%. Studies indicate that maltreatment of children alters their brain development, possibly increasing risk for tobacco use. Previous studies have documented associations between childhood maltreatment and adult health behaviors, demonstrating the influence of adverse experiences on tobacco use. We examined prevalence and associations between adverse childhood experiences and smoking among Nebraskans.
Methods We analyzed 2011 Nebraska Behavioral Risk Factor Surveillance System (Adverse Childhood Experience module) data, defining adverse childhood experience exposures as physical, sexual, and verbal abuse (ie, direct exposures), and household dysfunction associated with mental illness, substance abuse, divorce, domestic violence, and living with persons with incarceration histories (ie, environmental exposures). We estimated prevalence of exposures, taking into account the complex survey design. We used logistic regression with predicted margins to estimate adjusted relative risk for smoking by direct or environmental exposure.
Results Approximately 51% of Nebraskans experienced 1 or more adverse childhood events; 7% experienced 5 or more. Prevalence of environmental exposures (42%) was significantly higher than that of direct exposures (31%). Prevalence of individual exposures ranged from 6% (incarceration of a household member) to 25% (verbal abuse). Adjusted relative risks of smoking for direct and environmental exposures were 1.5 and 1.8, respectively.
Conclusion We present a new method of evaluating adverse childhood experience data. Prevalence of adverse childhood experiences is high among Nebraskans, and these exposures are associated with smoking. State-specific strategies to monitor adverse events among children and provide interventions might help to decrease the smoking rate in this population
Adverse Childhood Experiences and Adult Smoking, Nebraska, 2011
Introduction Smoking is a public health risk; the prevalence of smoking among adults in Nebraska is 18-4%. Studies indicate that maltreatment of children alters their brain development, possibly increasing risk for tobacco use. Previous studies have documented associations between childhood maltreatment and adult health behaviors, demonstrating the influence of adverse experiences on tobacco use. We examined prevalence and associations between adverse childhood experiences and smoking among Nebraskans.
Methods We analyzed 2011 Nebraska Behavioral Risk Factor Surveillance System (Adverse Childhood Experience module) data, defining adverse childhood experience exposures as physical, sexual, and verbal abuse (ie, direct exposures), and household dysfunction associated with mental illness, substance abuse, divorce, domestic violence, and living with persons with incarceration histories (ie, environmental exposures). We estimated prevalence of exposures, taking into account the complex survey design. We used logistic regression with predicted margins to estimate adjusted relative risk for smoking by direct or environmental exposure.
Results Approximately 51% of Nebraskans experienced 1 or more adverse childhood events; 7% experienced 5 or more. Prevalence of environmental exposures (42%) was significantly higher than that of direct exposures (31%). Prevalence of individual exposures ranged from 6% (incarceration of a household member) to 25% (verbal abuse). Adjusted relative risks of smoking for direct and environmental exposures were 1.5 and 1.8, respectively.
Conclusion We present a new method of evaluating adverse childhood experience data. Prevalence of adverse childhood experiences is high among Nebraskans, and these exposures are associated with smoking. State-specific strategies to monitor adverse events among children and provide interventions might help to decrease the smoking rate in this population
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Effects of heat strain on cognitive function among a sample of miners.
Heat stress is associated with workplace injuries, likely through a combination of fatigue, reduced cognitive function, and thermal discomfort. The purpose of this study was to evaluate four cognitive tasks for sensitivity to heat stress. Eight participants performed treadmill exercise followed by assessments of serial reaction time (RT), Stroop effect, verbal delayed memory, and continuous performance working memory in an environmental chamber. A control (21.1 °C) trial, and Hot 1 and Hot 2 (both 37.8 °C) trials were run sequentially on two separate days to evaluate the four cognitive tasks. Heat strain (comparing Hot 1 and Hot 2 with the control trial) resulted in impairments in the serial RT test response and Stroop accuracy. Delayed memory was impacted only in the Hot 2 trial compared with the control trial. Given the demonstrated impact of heat on cognitive processes relevant to workers real-world functioning in the workplace, understanding how to assess and monitor vigilant attention in the workplace is essential
Decreased Ebola Transmission after Rapid Response to Outbreaks in Remote Areas, Liberia, 2014
We measured the reproduction number before and after interventions were implemented to reduce Ebola transmission in 9 outbreaks in Liberia during 2014. We evaluated risk factors for secondary cases and the association between patient admission to an Ebola treatment unit (ETU) and survival. The reproduction number declined 94% from 1.7 (95% CI 1.1–2.6) to 0.1 (95% CI 0.02–0.6) after interventions began. The risk for secondary infections was 90% lower for patients admitted to an ETU (risk ratio 0.1, 95% CI 0.04–0.3) than for those who died in the community. The case-fatality rate was 68% (95% CI 60–74), and ETU admission was associated with a 50% reduction in death (hazard ratio 0.5, 95% CI 0.4–0.8). Isolation and treatment of Ebola patients had the dual benefit of interrupting community transmission and improving survival
Secondary Infections with Ebola Virus in Rural Communities, Liberia and Guinea, 2014–2015
Persons who died of Ebola virus disease at home in rural communities in Liberia and Guinea resulted in more secondary infections than persons admitted to Ebola treatment units. Intensified monitoring of contacts of persons who died of this disease in the community is an evidence-based approach to reduce virus transmission in rural communities
Decreased Ebola Transmission after Rapid Response to Outbreaks in Remote Areas, Liberia, 2014
Secondary Infections with Ebola Virus in Rural Communities, Liberia and Guinea, 2014–2015
Sulfonamides as Selective Na<sub>V</sub>1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity
Because of its strong genetic validation,
Na<sub>V</sub>1.7 has
attracted significant interest as a target for the treatment of pain.
We have previously reported on a number of structurally distinct bicyclic
heteroarylsulfonamides as Na<sub>V</sub>1.7 inhibitors that demonstrate
high levels of selectivity over other Na<sub>V</sub> isoforms. Herein,
we report the discovery and optimization of a series of atropisomeric
quinolinone sulfonamide inhibitors [Bicyclic sulfonamide compounds as sodium channel inhibitors
and their preparation. WO 2014201206, 2014] of Na<sub>V</sub>1.7, which demonstrate nanomolar inhibition of
Na<sub>V</sub>1.7 and exhibit high levels of selectivity over other
sodium channel isoforms. After optimization of metabolic and pharmacokinetic
properties, including PXR activation, CYP2C9 inhibition, and CYP3A4
TDI, several compounds were advanced into in vivo target engagement
and efficacy models. When tested in mice, compound <b>39</b> (AM-0466) demonstrated robust pharmacodynamic activity in a Na<sub>V</sub>1.7-dependent model of histamine-induced pruritus (itch) and
additionally in a capsaicin-induced nociception model of pain without
any confounding effect in open-field activity
Sulfonamides as Selective Na<sub>V</sub>1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity
Because of its strong genetic validation,
Na<sub>V</sub>1.7 has
attracted significant interest as a target for the treatment of pain.
We have previously reported on a number of structurally distinct bicyclic
heteroarylsulfonamides as Na<sub>V</sub>1.7 inhibitors that demonstrate
high levels of selectivity over other Na<sub>V</sub> isoforms. Herein,
we report the discovery and optimization of a series of atropisomeric
quinolinone sulfonamide inhibitors [Bicyclic sulfonamide compounds as sodium channel inhibitors
and their preparation. WO 2014201206, 2014] of Na<sub>V</sub>1.7, which demonstrate nanomolar inhibition of
Na<sub>V</sub>1.7 and exhibit high levels of selectivity over other
sodium channel isoforms. After optimization of metabolic and pharmacokinetic
properties, including PXR activation, CYP2C9 inhibition, and CYP3A4
TDI, several compounds were advanced into in vivo target engagement
and efficacy models. When tested in mice, compound <b>39</b> (AM-0466) demonstrated robust pharmacodynamic activity in a Na<sub>V</sub>1.7-dependent model of histamine-induced pruritus (itch) and
additionally in a capsaicin-induced nociception model of pain without
any confounding effect in open-field activity