Impact of the intraseasonal variability of large-scale circulation over the Western North Pacific on the characteristics of tropical cyclone track

The life cycle of the Southeast Asian–western North Pacific monsoon circulation is established by the northward migrations of the monsoon trough and the western Pacific subtropical anticyclone, and is reflected by the intraseasonal variations of mo nsoon westerlies and trad e easterlies in the form of an east–west seesaw oscillation. In this paper, an effort is made to disclose the influence of this monsoon circulation on tropical cyclone tracks during its different ph ases using composite charts of large-scale circulation for certain types of tracks. A majority of straight-moving (recurving) tropical cyclones appear during weak (strong) monsoon west- erlies and strong (weak) trade easterlies. The monsoon conditions associated with straight-moving tropical cyclones are linked to the intensified subtropical anticyclone, while that associated with recurving tropical cyclones is coupled with the deepened monsoon trough. The relationship between genesis locations and track characteristics is evolved from the intraseasonal variation of the monsoon circulation reflected by the east– west oscillation of monsoon westerlies and trade easterlies. Composite circulation differences between the flows associated with the two types of tropical cyclone tracks show a vertically uniform short wave train along the North Pacific rim, as portrayed by the Pacific–Japan oscillation. During the extreme phases of the monsoon life cycle, the anomalous circulation pattern east of Taiwan resembles this anomalous short wave train. A vorticity budget analysis of the strong monsoon condition reveals a vorticity tendency dipole with a positive zone to the north and a negative zone to the south of the deepened monsoon trough. This meridional juxtaposition of vorticity tendency propagates the monsoon trough northward. The interaction of a tropical cyclone with the monsoon trough intensifies the north–south juxtaposition of the vorticity tendency and deflects the tropical cyclone northward. In contrast, during weak monsoon conditions, the interaction be- tween a tropical cyclone and the subtropical high results in a northwestward motion steered by the intensified trade easterlies. The accurate prediction of the monsoon trough and the subtropical anticyclone variations coupled with the monsoon life cycle may help to improve the forecasting of tropical cyclone tracks

Pressure Dependence of Fragile-to-Strong Transition and a Possible Second Critical Point in Supercooled Confined Water

By confining water in nano-pores of silica glass, we can bypass the crystallization and study the pressure effect on the dynamical behavior in deeply supercooled state using neutron scattering. We observe a clear evidence of a cusp-like fragile-to-strong (F-S) dynamic transition. Here we show that the transition temperature decreases steadily with an increasing pressure, until it intersects the homogenous nucleation temperature line of bulk water at a pressure of 1600 bar. Above this pressure, it is no longer possible to discern the characteristic feature of the F-S transition. Identification of this end point with the possible second critical point is discussed.Comment: 4 pages, 3 figure

Where does stress happen? Ecological momentary assessment of daily stressors using a mobile phone app. [Journal article]

Despite the importance of daily stress to individuals' health and wellbeing, few studies have explored where stress happens in real time, that is, dynamic stress processes in different spaces. As such, stress interventions rarely account for the environment in which stress occurs. We used mobile phone based ecological momentary assessment (EMA) to collect daily stress data. Thirty-three participants utilized a mobile-phone-based EMA app to self-report stressors as they went about their daily lives. Geographic coordinates were automatically collected with each stress report. Data from thematic analysis of stressors by location (home, work, work from home, other) were used to determine whether certain stressors were more prevalent in certain environments. Nine daily stressors significantly differed by location. Work-related stress was reported more often at work. Pets, household chores, sleep, and media-related stressors were reported most at home. Physical illnesses, vehicle issues, and safety/security stressors occurred most often while participants were "working from home." Traffic-related stress was experienced more commonly in "other" environments. Other 18 stressors were generated regardless of location, suggesting that these stressors were persistent and without respect to location. Study findings expand the understanding of environments in which specific stressors occur, providing baseline data for potential targeted "just-in-time" stress interventions tailored to unique stressors in specific environments. We also provide findings related to the "work from home" phenomenon. Further work is needed to better understand the unique stressors among the large number of individuals who transitioned to working from home during and after the COVID-19 pandemic

Onshore/ offshore wide-angle deep seismic profiling in Taiwan

In summer 1995, in collaboration with the deep multi-channel seismic profiling project around the island of Taiwan, anonshore-offshore wide-angle deep seismic profiling experiment was conducted in Taiwan. The results are expected to provide the first complete seismic images of the deep crustal structure for a better understanding of the Taiwan orogeny and subduction-collision system. The experiment consists of three profiles, one along each of the central and southern cross-island highways and another on the south-link highway of the island. For the first two lines, 35 three-component portable seismographs were deployed along each of the 116 and 135 km-long profiles onshore, with airgun shots being fired at distances eastward form the east coast of up to 133 km and 170 km, respectively. On the third line, 6 stations were deployed along the 20 km-long profile. For this line, the R/V Ewing provided shots from the Philippine Sea westward to the eastern coast of the Hengchun Peninsula and then from the western coast of the Hengchun Peninsula westward away from Taiwan. The total length of the third line was about 310 km. The average station intervals were about 4 km. The preliminary results along the three profiles show a very thick crust beneath Taiwan. In addition, the velocity structures show that lateral variation of velocity in the upper crust is generally larger than that in the lower crust and uppermost mantle. Large thickness variations in the crust were also obtained. The crustal thickness beneath Taiwan diminishes gradually toward the west, but dramatically toward the east. The topographic high is not well associated with the crustal thickness. The thickest crust is to the east of the central mountain range, which may indicate that Taiwan has not yet reached its isostatic equilibrium. In this paper, the preliminary results along the southern cross-island profile are given as an example. Detailed results of the three profiles will be given elsewhere

IRIS: Efficient Visualization, Data Analysis and Experiment Management for Wireless Sensor Networks

The design of ubiquitous computing environments is challenging, mainly due to the unforeseeable impact of real-world environments on the system performance. A crucial step to validate the behavior of these systems is to perform in-field experiments under various conditions. We introduce IRIS, an experiment management and data processing tool allowing the definition of arbitrary complex data analysis applications. While focusing on Wireless Sensor Networks, IRIS supports the seamless integration of heterogeneous data gathering technologies. The resulting flexibility and extensibility enable the definition of various services, from experiment management and performance evaluation to user-specific applications and visualization. IRIS demonstrated its effectiveness in three real-life use cases, offering a valuable support for in-field experimentation and development of customized applications for interfacing the end user with the system

Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor.

Background and objectivesObesity is a global epidemic which increases the risk of the metabolic syndrome. Cathelicidin (LL-37 and mCRAMP) is an antimicrobial peptide with an unknown role in obesity. We hypothesize that cathelicidin expression correlates with obesity and modulates fat mass and hepatic steatosis.Materials and methodsMale C57BL/6 J mice were fed a high-fat diet. Streptozotocin was injected into mice to induce diabetes. Experimental groups were injected with cathelicidin and CD36 overexpressing lentiviruses. Human mesenteric fat adipocytes, mouse 3T3-L1 differentiated adipocytes and human HepG2 hepatocytes were used in the in vitro experiments. Cathelicidin levels in non-diabetic, prediabetic and type II diabetic patients were measured by enzyme-linked immunosorbent assay.ResultsLentiviral cathelicidin overexpression reduced hepatic steatosis and decreased the fat mass of high-fat diet-treated diabetic mice. Cathelicidin overexpression reduced mesenteric fat and hepatic fatty acid translocase (CD36) expression that was reversed by lentiviral CD36 overexpression. Exposure of adipocytes and hepatocytes to cathelicidin significantly inhibited CD36 expression and reduced lipid accumulation. Serum cathelicidin protein levels were significantly increased in non-diabetic and prediabetic patients with obesity, compared with non-diabetic patients with normal body mass index (BMI) values. Prediabetic patients had lower serum cathelicidin protein levels than non-diabetic subjects.ConclusionsCathelicidin inhibits the CD36 fat receptor and lipid accumulation in adipocytes and hepatocytes, leading to a reduction of fat mass and hepatic steatosis in vivo. Circulating cathelicidin levels are associated with increased BMI. Our results demonstrate that cathelicidin modulates the development of obesity

Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo

BACKGROUND: 2,5-Dimethyl-celecoxib (DMC) is a close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib (Celebrex(®)) that lacks COX-2-inhibitory function. However, despite its inability to block COX-2 activity, DMC is able to potently mimic the anti-tumor effects of celecoxib in vitro and in vivo, indicating that both of these drugs are able to involve targets other than COX-2 to exert their recognized cytotoxic effects. However, the molecular components that are involved in mediating these drugs' apoptosis-stimulatory consequences are incompletely understood. RESULTS: We present evidence that celecoxib and DMC are able to down-regulate the expression of survivin, an anti-apoptotic protein that is highly expressed in tumor cells and known to confer resistance of such cells to anti-cancer treatments. Suppression of survivin is specific to these two drugs, as other coxibs (valdecoxib, rofecoxib) or traditional NSAIDs (flurbiprofen, indomethacin, sulindac) do not affect survivin expression at similar concentrations. The extent of survivin down-regulation by celecoxib and DMC in different tumor cell lines is somewhat variable, but closely correlates with the degree of drug-induced growth inhibition and apoptosis. When combined with irinotecan, a widely used anticancer drug, celecoxib and DMC greatly enhance the cytotoxic effects of this drug, in keeping with a model that suppression of survivin may be beneficial to sensitize cancer cells to chemotherapy. Remarkably, these effects are not restricted to in vitro conditions, but also take place in tumors from drug-treated animals, where both drugs similarly repress survivin, induce apoptosis, and inhibit tumor growth in vivo. CONCLUSION: In consideration of survivin's recognized role as a custodian of tumor cell survival, our results suggest that celecoxib and DMC might exert their cytotoxic anti-tumor effects at least in part via the down-regulation of survivin – in a manner that does not require the inhibition of cyclooxygenase-2. Because inhibition of COX-2 appears to be negligible, it might be worthwhile to further evaluate DMC's potential as a non-coxib alternative to celecoxib for anti-cancer purposes

Improved Functional Outcome After Peripheral Nerve Stimulation of the Impaired Forelimb Post-stroke

Lack of blood flow to the brain, i.e., ischemic stroke, results in loss of nerve cells and therefore loss of function in the effected brain regions. There is no effective treatment to improve lost function except restoring blood flow within the first several hours. Rehabilitation strategies are widely used with limited success. The purpose of this study was to examine the effect of electrical stimulation on the impaired upper extremity to improve functional recovery after stroke. We developed a rodent model using an electrode cuff implant onto a single peripheral nerve (median nerve) of the paretic forelimb and applied daily electrical stimulation. The skilled forelimb reaching test was used to evaluate functional outcome after stroke and electrical stimulation. Anterograde axonal tracing from layer V pyramidal neurons with biotinylated dextran amine was done to evaluate the formation of new neuronal connections from the contralesional cortex to the deafferented spinal cord. Rats receiving electrical stimulation on the median nerve showed significant improvement in the skilled forelimb reaching test in comparison with stroke only and stroke with sham stimulation. Rats that received electrical stimulation also exhibited significant improvement in the latency to initiate adhesive removal from the impaired forelimb, indicating better sensory recovery. Furthermore, axonal tracing analysis showed a significant higher midline fiber crossing index in the cervical spinal cord of rats receiving electrical stimulation. Our results indicate that direct peripheral nerve stimulation leads to improved sensorimotor recovery in the stroke-impaired forelimb, and may be a useful approach to improve post-stroke deficits in human patients

Construction and characterization of an expressed sequenced tag library for the mosquito vector Armigeres subalbatus

<p>Abstract</p> <p>Background</p> <p>The mosquito, <it>Armigeres subalbatus</it>, mounts a distinctively robust innate immune response when infected with the nematode <it>Brugia malayi</it>, a causative agent of lymphatic filariasis. In order to mine the transcriptome for new insight into the cascade of events that takes place in response to infection in this mosquito, 6 cDNA libraries were generated from tissues of adult female mosquitoes subjected to immune-response activation treatments that lead to well-characterized responses, and from aging, naïve mosquitoes. Expressed sequence tags (ESTs) from each library were produced, annotated, and subjected to comparative analyses.</p> <p>Results</p> <p>Six libraries were constructed and used to generate 44,940 expressed sequence tags, of which 38,079 passed quality filters to be included in the annotation project and subsequent analyses. All of these sequences were collapsed into clusters resulting in 8,020 unique sequence clusters or singletons. EST clusters were annotated and curated manually within ASAP (A Systematic Annotation Package for Community Analysis of Genomes) web portal according to BLAST results from comparisons to Genbank, and the <it>Anopheles gambiae </it>and <it>Drosophila melanogaster </it>genome projects.</p> <p>Conclusion</p> <p>The resulting dataset is the first of its kind for this mosquito vector and provides a basis for future studies of mosquito vectors regarding the cascade of events that occurs in response to infection, and thereby providing insight into vector competence and innate immunity.</p

800 meV localization energy in GaSb/GaAs/Al0.3Ga0.7As quantum dots

This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Appl. Phys. Lett. 102, 052115 (2013) and may be found at https://doi.org/10.1063/1.4791678.DFG, 120319092, ERA NanoSci - Coupling of Single Quantum Dots to Two-Dimensional System