Multi joint short term resistance training strength zone evaluated on maximal strength, maximal ısometric strength, peak isom reach, maximal isometric endurance and muscular local endurance in resistance trained men

To resistance trained men multi joint short term strength zone periodization for strength training non-periodic progression producted by performing peak isom reach periodize model on maximal strength and maximal isometric strength for peak isom reach periodize model for strength development on isometric strength. Other maximal isometric endurance and muscular local endurance were provided on load-time curve intensity in muscular isom change load intensity. In this case, determination on strength zone periodization was performed on 1-5RM strength zone one session set-up and maximal isometric strength on load-time curve at peak isom reach development. The peak isom reach for periodic strength sessions were conducted on strength/speed at 80% of 1RM (2.5 s) and maximal strength/force at 90% of 1RM (4 s) on maximal isometric strength. Indeed, multi joint strength zones developed the maximal squat (ES=0.55; p=0.000; t=-4.837), bench press (ES=0.46; p=0.000; t=7.386) and deadlift (ES=0.50; p=0.000; t=-4.837) in resistance trained men. This study were noted to peak isom reach periodize model performance developed on multi joint load repetition may be use for maximize performance in continuum repetition zone.

Some indazoles reduced the activity of human serum paraoxonase 1, an antioxidant enzyme: in vitro inhibition and molecular modeling studies

Background: Paraoxonase 1 (PON1: EC 3.1.8.1) is a vital antioxidant enzyme against mainly atherosclerosis and many other diseases associated with oxidative stress. Thus, studies related to PON1 have an important place in the pharmacology. In this study, we aimed to evaluate the in vitro inhibition effects of some indazoles on the activity of human PON1. Methods: PON1 was purified from human serum with a specific activity of 5000?U/mg and 13.50% yield by using simple chromatographic methods. Results: The indazoles showed K i values in a range of 26.0?±?3.00–111?±?31.0?µM against hPON1. All these indazoles exhibited competitive inhibition. In addition, molecular docking studies were performed in order to assess the probable binding mechanisms into the active site of hPON1. Molecular modeling studies confirmed our results. Conclusions: Inhibition of PON1 by indazoles supplies a verification to further consideration of limitation dosage of indazole molecule groups as drug. © 2018 Informa UK Limited, trading as Taylor & Francis Grou

Uncuffed Endotracheal Tube Experience in Pediatric Patients with Laparotomy and Laparoscopic Surgeries

Aim. The aim of this study is to compare endotracheal tube leak, tube selection, mechanical ventilation, and side effects in the use of uncuffed tubes in both laparoscopic and laparotomy surgeries in pediatric patients. Material and Method. Patients who underwent laparotomy (LT group) or laparoscopic (LS group) surgery between 1 and 60 months. In the selection of uncuffed tubes, it was also planned to start endotracheal intubation with the largest uncuffed tube and to start intubation with a small uncuffed tube if the tube encounters resistance and does not pass. Mechanical parameters, endotracheal tube size, tube changes, and side effects are recorded. Results. A total of 102 patients, 38 females and 64 males, with a mean age of 10.9±8.1 months, body weight 7.1±3.7 kg, and height 67±15 cm, were included. 54 patients underwent laparoscopic surgery, and 48 patients underwent laparotomy. Tube exchange was performed in a total of 18 patients. In patients who underwent tube exchange, 11 patients were intubated with a smaller ETT number and others endotracheal intubation; when the MV parameters were TVe20%, a larger uncuffed tube was used due to PIP 30 cmH2O pressure. Patients with aspiration were not found in the LT and LS groups. There was no difference in the intergroup evaluation for postoperative side effects such as cough, laryngospasm, stridor, and aspiration. Conclusion. There was no significant difference between the groups in terms of tube changes and side effects. So that we can start with the largest possible uncuffed tube to decrease ETT leak, both laparotomy and laparoscopic operations in children can be achieved with safe mechanical ventilation and target tidal volume

Subconjunctival Hemorrhage May Not Always Be Benign

On dokuz yaşında erkek hasta sağ gözde kızarıklık şikayetiyle acil servise başvurdu. Anamnezde kızarıklık şikayeti ile ilişkili görme azalması, batma, sulanma ya da travma tariflemiyordu. Her iki gözde en iyi düzeltilmiş görme keskinliği 1.0 düzeyindeydi. Biyomikroskopik muayenede sağ gözün nazal ve inferior kısımlarında subkonjonktival hemoraji (SKH) saptandı. Fundus muayenesinde ise sağ gözde, retina periferinde yerleşmiş yabancı cisim tespit edildi. Yabancı cisim tespit edilince daha ayrıntılı anamnez alındı. Bir gün önce evde cam kırıldığı öğrenildi ve muayenede saptanan yabancı cismin cam parçasına ait olabileceği düşünüldü. Sol gözde ön segment ve fundus muayenesinde patolojik bulguya rastlanmadı.Sağ göz retina periferinde yerleşmiş olan yabancı cismin etrafına argon lazer fotokoagülasyon yapıldı. Topikal antibiyotik ve antienflamatuar tedavi verildi ve yakın takip edildi. Hastanın 9 ay sonraki son kontrolünde görme düzeyi 1.0 olup herhangi bir inflamasyon bulgusu saptanmadı. Çoğu zaman masum bir klinik tablo olarak değerlendirilen SKH hastalarından detaylı bir anamnez alınmalı ve periferik fundus muayenesini de içine alan tam bir göz muayenesi yapılmalıdır.A 19-year-old male patient was admitted to emergency department complaining of redness in the right eye. His compliant was not associated with vision changes, increased tearing, pain, or trauma. The best-corrected visual acuity was 1.0 in both eyes. A slit-lamp biomicroscopic examination revealed subconjunctival hemorrhage (SCH) in nasal and inferior parts of the right eye. Intraocular foreign body which was located in peripheral retina was detected under fundus examination of the right eye. After detection of foreign body, detailed anamnesis was taken. According to anamnesis, a glass was broken at home one day ago and it was thought that intraocular foreign body could be a splinter from a glass. There were no abnormal findings on fundus and anterior chamber examination in the left eye. Argon-Laser photocoagulation was performed around the foreign body which was located in peripheral retina of right eye. Topical antibiotic and anti-inflammatory treatment were given and patient was followed closely. At last follow-up 9 months later, visual acuity was 1.0 and there was no sign of inflammation. Although SCH is generally a benign condition, clinicians should take detailed medical history and examine all parts of eye including peripheral of retina