13 research outputs found
Nanohyperthermia of malignant tumors.i. lanthanum-strontium manganite magnetic fluid as potential inducer of tumor hyperthermia
Objectives: To synthesize magnetic particles of lanthanum-strontium manganite, prepare the magnetic fluid (MF), evaluate the generation of heat by particles and determine their common toxiΡity. Methods: Nanoparticles based on the solid solutions of lanthanum-strontium manganite (La1-xSrxMnO3) have been synthesized by a sol-gel method. Conventional methods of experimental oncology were used. Results: Nanoparticles of ferromagnetic materials on the basis of solid solutions of lanthanum strontium manganite by sol-gel method were synthesized. It was shown the possibility to regulate the aggregate form of particles that are formed during the synthesis. Magnetic fluid based on the synthesized nanoparticles and water solutions of agarose have been produced. It was shown the possibility to heat this magnetic fluid up to 42β45 Β°Π‘ in externally applied alternating magnetic field (AMF) operated at 100β400 kHz. It was determined that under long-term influence of AMF nanofluid is heated up to temperature which is not over that of magnetic phase transition. It was detected that magnetic powder as well as fluid have not displayed acute toxicity or side effects (intraperitoneal or intratumoral administration) in animals either intact or with transplanted tumors. Conclusions: Possibility of synthesized magnetic fluid to generate heat in externally applied AMF as well as lack of side effects allow to consider its as a potential mean for tumor hyperthermia (HT)
Π‘ΠΈΠ½ΡΠ΅Π·, Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½Π° ΡΠ° Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΡΠ°Π»ΡΠ½Π° Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΡΠ»ΡΠΎΡΠΎΠ°Π»ΠΊΡΠ»Π·Π°ΠΌΡΡΠ΅Π½ΠΈΡ ΡΡΠ°Π·ΠΎΠ»ΡΠ΄ΠΈΠ½ΠΎΠ½ΡΠ² ΡΠ° ΡΡΠ°Π·ΠΈΠ½Π°Π½ΠΎΠ½ΡΠ², ΡΠΎ ΠΌΡΡΡΡΡΡ Π°ΠΌΡΠ½ΠΎΡΠΎΡΡΠΎΠ½Π°ΡΠ½ΠΈΠΉ Π°Π±ΠΎ Π°ΠΌΡΠ½ΠΎΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠ½ΠΈΠΉ ΡΡΠ°Π³ΠΌΠ΅Π½Ρ
2-R-2-RF-4-ΠΎxo-thiazolidines, thiazinanes, and bezothiazinanes incorporating a fragment of aminophosphonic or aminocarboxylic acid and a fluoroalkyl group at C-2 atom of the heterocycle have been prepared by cyclocondensation of the corresponding iminophosphonates or iminocarboxylates, RFCH(R)=NH [R = (EtO)2P(O), COOMe, RF = CF3, CHF2], with mercaptoacetic, 3-mercaptopropionic or thiosalicylic acid. The primary screening of the compounds on the antioxidant and antibacterial activity has been carried out. The antioxidant activity has been determined by the method based on auto-oxidation of adrenaline; the antibacterial activity has been investigated by the method of double serial dilution with the use of Hottinger broth. The compounds investigated show only an insignificant antioxidant effect and the low activity towards the strains of such bacteria as E. coli, Ps. aeroginosa, B. subtilis and St. aureus. Compounds bearing diethoxyphosphonyl or methoxycarbonyl group at C-2 atom of a five- or six-member heterocycle show the similar activity in general. For 2-fluoroalkyl substituted 4-thiazolidinon- or 4-bezothiazinanones a considerable growth of the culture biomass has been revealed, and it can find application for growth stimulation of producers of biologically active compounds. Compounds incorporating the thiazinanones or bezothiazinanones fragment reveal the prooxidant effect, and it can become a basis for manifestation of the antineoplastic or antimicrobic activity.Π¦ΠΈΠΊΠ»ΠΎΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΠΈΠ΅ΠΉ ΡΡΠΎΡΠ°Π»ΠΊΠΈΠ»Π·Π°ΠΌΠ΅ΡΠ΅Π½Π½ΡΡ
ΠΈΠΌΠΈΠ½ΠΎΡΠΎΡΡΠΎΠ½Π°ΡΠΎΠ² ΠΈ ΠΈΠΌΠΈΠ½ΠΎΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠΎΠ², RFCH(R)=NH [R = (EtO)2P(O), COOMe, RF = CF3, CHF2], Ρ ΡΠΈΠΎΠ³Π»ΠΈΠΊΠΎΠ»Π΅Π²ΠΎΠΉ, 3-ΠΌΠ΅ΡΠΊΠ°ΠΏΡΠΎΠΏΡΠΎΠΏΠΈΠΎΠ½ΠΎΠ²ΠΎΠΉ ΠΈΠ»ΠΈ ΡΠΈΠΎΡΠ°Π»ΠΈΡΠΈΠ»ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΠΎΠΉ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Ρ 2-R-2-RF-4-ΠΎΠΊΡΠΎ-ΡΠΈΠ°Π·ΠΎΠ»ΠΈΠ΄ΠΈΠ½Ρ, ΡΠΈΠ°Π·ΠΈΠ½Π°Π½Ρ ΠΈ Π±Π΅Π½Π·ΠΎΡΠΈΠ°Π·ΠΈΠ½Π°Π½Ρ, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠ΅ ΡΡΠ°Π³ΠΌΠ΅Π½Ρ Π°ΠΌΠΈΠ½ΠΎΡΠΎΡΡΠΎΠ½ΠΎΠ²ΠΎΠΉ ΠΈΠ»ΠΈ Π°ΠΌΠΈΠ½ΠΎΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ ΠΈ ΡΡΠΎΡΠ°Π»ΠΊΠΈΠ»ΡΠ½ΡΡ Π³ΡΡΠΏΠΏΡ Π²ΠΎΠ·Π»Π΅ Π‘-2 Π°ΡΠΎΠΌΠ° Π³Π΅ΡΠ΅ΡΠΎΡΠΈΠΊΠ»Π°. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΠΉ ΡΠΊΡΠΈΠ½ΠΈΠ½Π³ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ Π½Π° Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΡΡ ΠΈ Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ. ΠΠ½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ, Π±Π°Π·ΠΈΡΡΡΡΠΈΠΌΡΡ Π½Π° Π°ΡΡΠΎΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΠΈ Π°Π΄ΡΠ΅Π½Π°Π»ΠΈΠ½Π°, Π° Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΡ β ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π΄Π²ΡΠΊΡΠ°ΡΠ½ΡΡ
ΡΠ΅ΡΠΈΠΉΠ½ΡΡ
ΡΠ°Π·Π±Π°Π²Π»Π΅Π½ΠΈΠΉ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π±ΡΠ»ΡΠΎΠ½Π° Π₯ΠΎΡΡΠΈΠ½Π³Π΅ΡΠ°. ΠΠ·ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ ΠΏΡΠΎΡΠ²Π»ΡΡΡ ΡΠΎΠ»ΡΠΊΠΎ Π½Π΅Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΡΠΉ ΡΡΡΠ΅ΠΊΡ ΠΈ ΡΠ²Π»ΡΡΡΡΡ ΠΌΠ°Π»ΠΎΠ°ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½ΡΡ
ΡΡΠ°ΠΌΠΌΠΎΠ² Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ E. coli, Ps. aeroginosa, B. subtilis ΠΈ St. aureus. Π‘ΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ Ρ Π΄ΠΈΡΡΠΎΠΊΡΠΈΡΠΎΡΡΠΎΠ½ΠΈΠ»ΡΠ½ΠΎΠΉ ΠΈΠ»ΠΈ ΠΌΠ΅ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠ±ΠΎΠ½ΠΈΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠΎΠΉ Π²ΠΎΠ·Π»Π΅ Π‘-2 Π°ΡΠΎΠΌΠ° ΠΏΡΡΠΈ- ΠΈΠ»ΠΈ ΡΠ΅ΡΡΠΈΡΠ»Π΅Π½Π½ΠΎΠ³ΠΎ Π³Π΅ΡΠ΅ΡΠΎΡΠΈΠΊΠ»Π° Π² ΠΎΠ±ΡΠ΅ΠΌ ΠΏΡΠΎΡΠ²Π»ΡΡΡ Π±Π»ΠΈΠ·ΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ. ΠΠ»Ρ 2-ΡΡΠΎΡΠ°Π»ΠΊΠΈΠ»Π·Π°ΠΌΠ΅ΡΠ΅Π½Π½ΡΡ
4-ΡΠΈΠ°Π·ΠΎΠ»ΠΈΠ΄ΠΈΠ½ΠΎΠ½- ΠΈΠ»ΠΈ 4-Π±Π΅Π½Π·ΠΎΡΠΈΠ°Π·ΠΈΠ½Π°Π½ΠΎΠ½ ΡΠΎΡΡΠΎΠ½Π°ΡΠΎΠ² Π²ΡΡΠ²Π»Π΅Π½ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΠΏΡΠΈΡΠΎΡΡ Π±ΠΈΠΎΠΌΠ°ΡΡΡ ΠΊΡΠ»ΡΡΡΡ Π² ΡΡΠ°Π²Π½Π΅Π½ΠΈΠΈ Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ΠΌ, ΡΡΠΎ ΠΌΠΎΠΆΠ΅Ρ Π½Π°ΠΉΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π΄Π»Ρ ΡΡΠΈΠΌΡΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠΎΡΡΠ° ΠΏΡΠΎΠ΄ΡΡΠ΅Π½ΡΠΎΠ² Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ. Π‘ΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ Ρ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠΌ ΡΠΈΠ°Π·ΠΈΠ½Π°Π½ΠΎΠ½Π° ΠΈΠ»ΠΈ Π±Π΅Π½Π·ΠΎΡΠΈΠ°Π·ΠΈΠ½Π°Π½ΠΎΠ½Π° ΠΏΡΠΎΡΠ²Π»ΡΡΡ ΠΏΡΠΎΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΡΠΉ ΡΡΡΠ΅ΠΊΡ, ΡΡΠΎ ΠΌΠΎΠΆΠ΅Ρ ΡΡΠ°ΡΡ ΠΎΡΠ½ΠΎΠ²ΠΎΠΉ Π΄Π»Ρ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠΉ ΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ.Π¦ΠΈΠΊΠ»ΠΎΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΡΡΡ ΡΠ»ΡΠΎΡΠΎΠ°Π»ΠΊΡΠ»Π·Π°ΠΌΡΡΠ΅Π½ΠΈΡ
ΡΠΌΡΠ½ΠΎΡΠΎΡΡΠΎΠ½Π°ΡΡΠ² ΡΠ° ΡΠΌΡΠ½ΠΎΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΡΠ², RFCH(R)=NH [R = (EtO)2P(O), COOMe, RF = CF3, CHF2], Π· ΡΡΠΎΠ³Π»ΡΠΊΠΎΠ»Π΅Π²ΠΎΡ, 3-ΠΌΠ΅ΡΠΊΠ°ΠΏΡΠΎΠΏΡΠΎΠΏΡΠΎΠ½ΠΎΠ²ΠΎΡ Π°Π±ΠΎ ΡΡΠΎΡΠ°Π»ΡΡΠΈΠ»ΠΎΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΡ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΎ 2-R-2-RF-4-ΠΎΠΊΡΠΎ-ΡΡΠ°Π·ΠΎΠ»ΡΠ΄ΠΈΠ½ΠΈ, ΡΡΠ°Π·ΠΈΠ½Π°Π½ΠΈ ΡΠ° Π±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΈΠ½Π°Π½ΠΈ, ΡΠΎ ΠΌΡΡΡΡΡΡ ΡΡΠ°Π³ΠΌΠ΅Π½Ρ Π°ΠΌΡΠ½ΠΎΡΠΎΡΡΠΎΠ½ΠΎΠ²ΠΎΡ Π°Π±ΠΎ Π°ΠΌΡΠ½ΠΎΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ ΡΠ° ΡΠ»ΡΠΎΡΠΎΠ°Π»ΠΊΡΠ»ΡΠ½Ρ Π³ΡΡΠΏΡ Π±ΡΠ»Ρ Π‘-2 Π°ΡΠΎΠΌΠ° Π³Π΅ΡΠ΅ΡΠΎΡΠΈΠΊΠ»Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΏΠ΅ΡΠ²ΠΈΠ½Π½ΠΈΠΉ ΡΠΊΡΠΈΠ½ΡΠ½Π³ ΡΠΏΠΎΠ»ΡΠΊ Π½Π° Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½Ρ ΡΠ° Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΡΠ°Π»ΡΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ. ΠΠ½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ Π²ΠΈΠ·Π½Π°ΡΠ°Π»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ, ΡΠΎ Π±Π°Π·ΡΡΡΡΡΡ Π½Π° Π°ΡΡΠΎΠΎΠΊΠΈΡΠ½Π΅Π½Π½Ρ Π°Π΄ΡΠ΅Π½Π°Π»ΡΠ½Ρ, Π° Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΡΠ°Π»ΡΠ½Ρ β ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π΄Π²ΠΎΠΊΡΠ°ΡΠ½ΠΈΡ
ΡΠ΅ΡΡΠΉΠ½ΠΈΡ
ΡΠΎΠ·Π²Π΅Π΄Π΅Π½Ρ Π· Π²ΠΈΠΊΠΎΡΠΈΡΡΠ°Π½Π½ΡΠΌ Π±ΡΠ»ΡΠΉΠΎΠ½Ρ Π₯ΠΎΡΡΠΈΠ½Π³Π΅ΡΠ°. ΠΠΈΠ²ΡΠ΅Π½Ρ ΡΠΏΠΎΠ»ΡΠΊΠΈ ΠΏΡΠΎΡΠ²Π»ΡΡΡΡ ΡΡΠ»ΡΠΊΠΈ Π½Π΅Π·Π½Π°ΡΠ½ΠΈΠΉ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΠΈΠΉ Π΅ΡΠ΅ΠΊΡ ΡΠ° Ρ ΠΌΠ°Π»ΠΎΠ°ΠΊΡΠΈΠ²Π½ΠΈΠΌΠΈ ΠΏΠΎ Π²ΡΠ΄Π½ΠΎΡΠ΅Π½Π½Ρ Π΄ΠΎ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½ΠΈΡ
ΡΡΠ°ΠΌΡΠ² Π±Π°ΠΊΡΠ΅ΡΡΠΉ E. coli, Ps. aeroginosa, B. subtilis ΡΠ° St. aureus. Π‘ΠΏΠΎΠ»ΡΠΊΠΈ Π· Π΄ΡΠ΅ΡΠΎΠΊΡΠΈΡΠΎΡΡΠΎΠ½ΡΠ»ΡΠ½ΠΎΡ Π°Π±ΠΎ ΠΌΠ΅ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠ±ΠΎΠ½ΡΠ»ΡΠ½ΠΎΡ Π³ΡΡΠΏΠΎΡ Π±ΡΠ»Ρ Π‘-2 Π°ΡΠΎΠΌΠ° ΠΏβΡΡΠΈ- Π°Π±ΠΎ ΡΠ΅ΡΡΠΈΡΠ»Π΅Π½Π½ΠΎΠ³ΠΎ Π³Π΅ΡΠ΅ΡΠΎΡΠΈΠΊΠ»Ρ Π·Π°Π³Π°Π»ΠΎΠΌ ΠΏΡΠΎΡΠ²Π»ΡΡΡΡ ΠΏΠΎΠ΄ΡΠ±Π½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ. ΠΠ»Ρ 2-ΡΠ»ΡΠΎΡΠΎΠ°Π»ΠΊΡΠ»Π·Π°ΠΌΡΡΠ΅Π½ΠΈΡ
4-ΡΡΠ°Π·ΠΎΠ»ΡΠ΄ΠΈΠ½ΠΎΠ½- Π°Π±ΠΎ 4-Π±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΈΠ½Π°Π½ΠΎΠ½ ΡΠΎΡΡΠΎΠ½Π°ΡΡΠ² Π²ΠΈΡΠ²Π»Π΅Π½ΠΎ Π·Π½Π°ΡΠ½ΠΈΠΉ ΠΏΡΠΈΡΡΡΡ Π±ΡΠΎΠΌΠ°ΡΠΈ ΠΊΡΠ»ΡΡΡΡ ΠΏΠΎΡΡΠ²Π½ΡΠ½ΠΎ Π· ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ΠΌ, ΡΠΎ ΠΌΠΎΠΆΠ΅ Π·Π½Π°ΠΉΡΠΈ Π·Π°ΡΡΠΎΡΡΠ²Π°Π½Π½Ρ Π΄Π»Ρ ΡΡΠΈΠΌΡΠ»ΡΠ²Π°Π½Π½Ρ ΡΠΎΡΡΡ ΠΏΡΠΎΠ΄ΡΡΠ΅Π½ΡΡΠ² Π±ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎ Π°ΠΊΡΠΈΠ²Π½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ. Π‘ΠΏΠΎΠ»ΡΠΊΠΈ Π· ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠΌ ΡΡΠ°Π·ΠΈΠ½Π°Π½ΠΎΠ½Ρ Π°Π±ΠΎ Π±Π΅Π½Π·ΠΎΡΡΠ°Π·ΠΈΠ½Π°Π½ΠΎΠ½Ρ ΠΏΡΠΎΡΠ²Π»ΡΡΡΡ ΠΏΡΠΎΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΠΈΠΉ Π΅ΡΠ΅ΠΊΡ, ΡΠΎ ΠΌΠΎΠΆΠ΅ ΡΡΠ°ΡΠΈ ΠΎΡΠ½ΠΎΠ²ΠΎΡ Π΄Π»Ρ ΠΏΡΠΎΡΠ²Ρ ΠΏΡΠΎΡΠΈΠΏΡΡ
Π»ΠΈΠ½Π½ΠΎΡ ΡΠ° Π°Π½ΡΠΈΠΌΡΠΊΡΠΎΠ±Π½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ
Simulation of the electron spin resonance peak shape for magnetic nanopowder formed by particles of different diameters
Results of simulation of shape of the electron spin resonance absorption peak for magnetic nanopowder are presented. The influence of magnetic particle diameter on the shape and on width of the resonance peak is shown. The role of internal magnetic anisotropy field is under discussion. The simulation results show a good agreement with the experimental data of the electron spin resonance absorption in a) FeβOβ_Triton, b) FeβOβ_Crio, nanopowder and the data of its X-ray analysis