Constraints on Omega_m and sigma_8 from weak lensing in RCS fields

We have analysed 53 square degrees of imaging data from the Red-Sequence Cluster Survey (RCS), and measured the excess correlations in the shapes of galaxies on scales out to ~1.5 degrees. We separate the signal into an ``E''- (lensing) and ``B''-mode (systematics), which allows us to study residual systematics. On scales larger than 10 arcminutes, we find no ``B''-mode. On smaller scales we find a small, but significant ``B''-mode. This signal is also present when we select a sample of bright galaxies. These galaxies are rather insensitive to observational distortions, and we therefore conclude that the oberved ``B''-mode is likely to be caused by intrinsic alignments. We therefore limit the cosmic shear analysis to galaxies with 22<R_C<24. We derive joint constraints on Omega_m and sigma_8, by marginalizing over Gamma, Omega_Lambda and the source redshift distribution, using different priors. We obtain a conservative constraint of $\sigma_8=0.45^{+0.09}_{-0.12} \Omega_m^{-0.55}$ (95% confidence). A better constraint is derived when we use Gaussian priors redshift distribution. For this choice of priors, we find $\sigma_8=(0.46^{+0.05}_{-0.07})\Omega_m^{-0.52}$ (95% confidence). Using our setof Gaussian priors, we find that we can place a lower bound on Gamma: Gamma>0.1+0.16\Omega_m$ (95% confidence). Comparison of the RCS results with three other recent cosmic shear measurements shows excellent agreement. The current weak lensing results are also in good agreement with CMB measurements, when we allow the reionization optical depth tau and the spectral index n_s to vary. We present a simple demonstration of how the weak lensing results can be used as a prior in the parameter estimation from CMB measurements to derive constraints on the reionization optical depth tau. (abridged)Comment: 9 pages, 6 figures, Accepted for publication in the Astrophysical Journa

How Diverse Detrital Environments Influence Nutrient Stoichiometry Between Males and Females of the Co-Occurring Container Mosquitoes \u3ci\u3eAedes albopictus\u3c/i\u3e, \u3ci\u3eAe. Aegypti\u3c/i\u3e, and \u3ci\u3eCulex quinquefasciatus\u3c/i\u3e

Allocation patterns of carbon and nitrogen in animals are influenced by food quality and quantity, as well as by inherent metabolic and physiological constraints within organisms. Whole body stoichiometry also may vary between the sexes who differ in development rates and reproductive allocation patterns. In aquatic containers, such as tree holes and tires, detrital inputs, which vary in amounts of carbon and nitrogen, form the basis of the mosquito-dominated food web. Differences in development times and mass between male and female mosquitoes may be the result of different reproductive constraints, which could also influence patterns of nutrient allocation. We examined development time, survival, and adult mass for males and females of three co-occurring species, Aedes albopictus, Ae. aegypti, and Culex quinquefasciatus, across environments with different ratios of animal and leaf detritus. We quantified the contribution of detritus to biomass using stable isotope analysis and measured tissue carbon and nitrogen concentrations among species and between the sexes. Development times were shorter and adults were heavier for Aedes in animal versus leaf-only environments, whereas Culex development times were invariant across detritus types. Aedes displayed similar survival across detritus types whereas C. quinquefasciatus showed decreased survival with increasing leaf detritus. All species had lower values of 15N and 13C in leaf-only detritus compared to animal, however, Aedes generally had lower tissue nitrogen compared to C. quinquefasciatus. There were no differences in the C:N ratio between male and female Aedes, however, Aedes were different than C. quinquefasciatus adults, with male C. quinquefasciatus significantly higher than females. Culex quinquefasciatus was homeostatic across detrital environments. These results allow us to hypothesize an underlying stoichiometric explanation for the variation in performance of different container species under similar detrital environments, and if supported may assist in explaining the production of vector populations in nature

Prerendered User Interfaces for Higher-Assurance Electronic Voting

We propose an electronic voting machine architecture in which the voting user interface is prerendered and published before election day. The prerendered user interface is a verifiable artifact—an electronic sample ballot—enabling public participation in the review, verification, usability testing, and accessibility testing of the ballot. Preparing the user interface outside of the voting machine dramatically reduces the amount and difficulty of software verification required to assure the correctness of the election result. We present a design for a high-assurance touchscreen voting machine that supports a wide range of user interface styles and demonstrate its feasibility by implementing it in less than 300 lines of Python code

Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic-aromatic interactions

Key contributions to protein structure and stability are provided by weakly polar interactions, which arise from asymmetric electronic distributions within amino acids and peptide bonds. Of particular interest are aromatic side chains whose directional π-systems commonly stabilize protein interiors and interfaces. Here, we consider aromatic-aromatic interactions within a model protein assembly: the dimer interface of insulin. Semi-classical simulations of aromatic-aromatic interactions at this interface suggested that substitution of residue TyrB26 by Trp would preserve native structure while enhancing dimerization (and hence hexamer stability). The crystal structure of a [TrpB26]insulin analog (determined as a T3Rf3 zinc hexamer at a resolution of 2.25 Å) was observed to be essentially identical to that of WT insulin. Remarkably and yet in general accordance with theoretical expectations, spectroscopic studies demonstrated a 150-fold increase in the in vitro lifetime of the variant hexamer, a critical pharmacokinetic parameter influencing design of long-acting formulations. Functional studies in diabetic rats indeed revealed prolonged action following subcutaneous injection. The potency of the TrpB26-modified analog was equal to or greater than an unmodified control. Thus, exploiting a general quantum-chemical feature of protein structure and stability, our results exemplify a mechanism-based approach to the optimization of a therapeutic protein assembly

Mortality benefit of angiotensin-converting enzyme inhibitors after cardiac events in patients with end-stage renal disease

Hypothesis/introduction. The risks and benefits of angiotensin-converting enzyme (ACE) inhibitors in patients with end-stage renal disease (ESRD) after cardiac events are unknown. We sought to determine the independent effect of ACE inhibitors (ACE-I) on long-term mortality in ESRD patients after cardiac events. Materials and methods. We analysed a prospective coronary care unit registry and identified 527 ESRD patients, 368 with complete data on medications prescribed, over eight years at a single, tertiary centre. Results. The overall mean age was 64.4±13.8 years with 54.9% men, and 59.2% African-American. A total of 143/386 (37.0%) were prescribed ACE-I during the hospital stay for cardiac reasons, including congestive heart failure (CHF) 52.8% and acute coronary syndromes (ACS) 47.2%. There were no significant differences in the rates of hypotension or arrhythmias in those who were treated with ACE-I versus those who were not. Survival analysis over three years, adjusted for known confounders, demonstrated a 37% reduction in all-cause mortality in those who received ACE-I, (p=0.0145). Conclusions. In the setting of coronary care unit admission for CHF and ACS, ESRD patients selected for ACE-I, did not have increased rates of adverse haemodynamic or arrhythmic complications. The use of ACE-I conferred an independent mortality reduction over long-term follow-up

The Orbit of WASP-12b Is Decaying

WASP-12b is a transiting hot Jupiter on a 1.09 day orbit around a late-F star. Since the planet's discovery in 2008, the time interval between transits has been decreasing by 29 ± 2 ms yr⁻¹. This is a possible sign of orbital decay, although the previously available data left open the possibility that the planet's orbit is slightly eccentric and is undergoing apsidal precession. Here, we present new transit and occultation observations that provide more decisive evidence for orbital decay, which is favored over apsidal precession by a ΔBIC of 22.3 or Bayes factor of 70,000. We also present new radial-velocity data that rule out the Rømer effect as the cause of the period change. This makes WASP-12 the first planetary system for which we can be confident that the orbit is decaying. The decay timescale for the orbit is P/P˙=3.25±0.23. Interpreting the decay as the result of tidal dissipation, the modified stellar tidal quality factor is Q′⋆=1.8×10⁵

The EXPLORE Project I: A Deep Search for Transiting Extrasolar Planets

(Abridged) We discuss the design considerations of the EXPLORE (EXtra-solar PLanet Occultation REsearch) project, a series of transiting planet searches using 4-m-class telescopes to continuously monitor a single field of stars in the Galactic Plane in each ~2 week observing campaign. We discuss the general factors which determine the efficiency and the number of planets found by a transit search, including time sampling strategy and field selection. The primary goal is to select the most promising planet candidates for radial velocity follow-up observations. We show that with very high photometric precision light curves that have frequent time sampling and at least two detected transits, it is possible to uniquely solve for the main parameters of the eclipsing system (including planet radius) based on several important assumptions about the central star. Together with a measured spectral type for the star, this unique solution for orbital parameters provides a powerful method for ruling out most contaminants to transiting planet candidates. For the EXPLORE project, radial velocity follow-up observations for companion mass determination of the best candidates are done on 8-m-class telescopes within two or three months of the photometric campaigns. This same-season follow-up is made possible by the use of efficient pipelines to produce high quality light curves within weeks of the observations. We conclude by presenting early results from our first search, EXPLORE I, in which we reached <1% rms photometric precision (measured over a full night) on ~37,000 stars to I <= 18.2.Comment: accepted by ApJ. Main points unchanged but more thorough discussion of some issues. 36 pages, including 14 figure

Search full text options here 2 of 4 KMT-2021-BLG-0912Lb: a microlensing super Earth around a K-type star

Aims. The light curve of the microlensing event KMT-2021-BLG-0912 exhibits a very short anomaly relative to a single-lens single-source form. We investigate the light curve for the purpose of identifying the origin of the anomaly. Methods. We model the light curve under various interpretations. From this, we find four solutions, in which three solutions are found under the assumption that the lens is composed of two masses (2L1S models), and the other solution is found under the assumption that the source is comprised of binary stars (1L2S model). The 1L2S model is ruled out based on the contradiction that the faint source companion is bigger than its primary, and one of the 2L1S solutions is excluded from the combination of the poorer fit, blending constraint, and lower overall probability, leaving two surviving solutions with the planet/host mass ratios of q similar to 2.8 x 10(-5) and similar to 1.1 x 10(-5). A subtle central deviation supports the possibility of a tertiary lens component, either a binary companion to the host with a very large or small separation, or a second planet lying near the Einstein ring, but it is difficult to claim a secure detection due to the marginal improvement of the fit, lack of consistency among different data sets, and difficulty in uniquely specifying the nature of the tertiary component. Results. With the observables of the event, it is estimated that the masses of the planet and host are similar to(6.9 M-circle plus, 0.75 M-circle dot) according to one solution and similar to(2.8 M-circle plus, 0.80 M-circle dot) according to the other, indicating that the planet is a super Earth around a K-type star, regardless of the solution. The fact that 16 (including the one reported in this work) out of 19 microlensing planets with M less than or similar to 10 M-circle plus were detected during the last 6 yr nicely demonstrates the importance of high-cadence global surveys in detecting very low-mass planets

Gene expression profiling to study racial differences after heart transplantation.

BackgroundThe basis for increased mortality after heart transplantation in African Americans and other non-Caucasian racial groups is poorly defined. We hypothesized that increased risk of adverse events is driven by biologic factors. To test this hypothesis in the Invasive Monitoring Attenuation through Gene Expression (IMAGE) study, we determined whether the event rate of the primary outcome of acute rejection, graft dysfunction, death, or retransplantation varied by race as a function of calcineurin inhibitor (CNI) levels and gene expression profile (GEP) scores.MethodsWe determined the event rate of the primary outcome, comparing racial groups, stratified by time after transplant. Logistic regression was used to compute the relative risk across racial groups, and linear modeling was used to measure the dependence of CNI levels and GEP score on race.ResultsIn 580 patients monitored for a median of 19 months, the incidence of the primary end point was 18.3% in African Americans, 22.2% in other non-Caucasians, and 8.5% in Caucasians (p &lt; 0.001). There were small but significant correlations of race and tacrolimus trough levels to the GEP score. Tacrolimus levels were similar among the races. Of patients receiving tacrolimus, other non-Caucasians had higher GEP scores than the other racial groups. African American recipients demonstrated a unique decrease in expression of the FLT3 gene in response to higher tacrolimus levels.ConclusionsAfrican Americans and other non-Caucasian heart transplant recipients were 2.5-times to 3-times more likely than Caucasians to experience outcome events in the Invasive Monitoring Attenuation through Gene Expression study. The increased risk of adverse outcomes may be partly due to the biology of the alloimmune response, which is less effectively inhibited at similar tacrolimus levels in minority racial groups

On Pathologies in KL-Regularized Reinforcement Learning from Expert Demonstrations

KL-regularized reinforcement learning from expert demonstrations has proved successful in improving the sample efficiency of deep reinforcement learning algorithms, allowing them to be applied to challenging physical real-world tasks. However, we show that KL-regularized reinforcement learning with behavioral reference policies derived from expert demonstrations can suffer from pathological training dynamics that can lead to slow, unstable, and suboptimal online learning. We show empirically that the pathology occurs for commonly chosen behavioral policy classes and demonstrate its impact on sample efficiency and online policy performance. Finally, we show that the pathology can be remedied by non-parametric behavioral reference policies and that this allows KL-regularized reinforcement learning to significantly outperform state-of-the-art approaches on a variety of challenging locomotion and dexterous hand manipulation tasks.Comment: Published in Advances in Neural Information Processing Systems 34 (NeurIPS 2021