44 research outputs found

    PRH/Hex: an oligomeric transcription factor and ,ultifunctional regulator of cell fate.

    Get PDF
    The PRH (proline-rich homeodomain) [also known as Hex (haematopoietically expressed homeobox)] protein is a critical regulator of vertebrate development. PRH is able to regulate cell proliferation and differentiation and is required for the formation of the vertebrate body axis, the haematopoietic and vascular systems and the formation of many vital organs. PRH is a DNAbinding protein that can repress and activate the transcription of its target genes using multiple mechanisms. In addition, PRH can regulate the nuclear transport of specific mRNAs making PRH a member of a select group of proteins that control gene expression at the transcriptional and translational levels. Recent biophysical analysis of the PRH protein has shown that it forms homo-oligomeric complexes in vivo and in vitro and that the proline-rich region of PRH forms a novel dimerization interface. Here we will review the current literature on PRH and discuss the complex web of interactions centred on this multifunctional protein

    A conspectus of the Lennoaceae

    No full text
    Volume: 52Start Page: 73End Page: 7

    A Revision of the Fern Genus Phanerophlebia (Dryopteridaceae)

    No full text
    Volume: 83Start Page: 168End Page: 19

    Innovations in the fern genus Phanerophlebia

    No full text
    Volume: 2Start Page: 445End Page: 44

    A New Combination in South American Polystichum

    No full text
    Volume: 79Start Page: 26End Page: 2

    Antheridiogen Response in Phanerophlebia and Related Fern Genera

    No full text
    Volume: 83Start Page: 30End Page: 3

    A new species and three generic transfers in the fern genus Notholaena (Pteridaceae)

    No full text
    Volume: 18Start Page: 120End Page: 12
    corecore