How to Strengthen and Reform Indian Medical Education System: Is Nationalization the Only Answer?

As India marches towards an exciting new future of growth and progress, medical education will play pivotal role in crafting a sustained development agenda. Efforts have to be undertaken to create a medical educational system that nourishes innovation, entrepreneurship and addresses the skill requirement of the growing economy. Last decade has been witness to phenomenal growth in numbers of the medical colleges, nursing colleges and other similar training institutions. This unregulated rapid growth in number of medical colleges has adversely impacted quality of training in India’s medical institutions. The policy of privatization of medical care has seriously undermined health services and further limited the access of the underprivileged. Therefore the only solution is centralization or nationalization or globalization of the entire medical education and health sectors or to join hands with world health organization, So that a uniform health cares facility can be given to each and every human being

Coordinated protein and DNA remodeling by human HLTF and comparison of its activity with Bloom Syndrome helicase protein

Human HLTF (Helicase Like Transcription Factor) is a member of the Swi2/Snf2 family of ATP-driven molecular motor proteins. Like many members of Swi2/Snf2 family, HLTF does not exhibit a canonical DNA helicase activity but has an ATP hydrolysis-driven double stranded (ds) DNA translocase activity. The biological importance of HLTF is indicated by the finding that it has a role in replication of damaged DNA and preventing genome rearrangement, and in accord, it is considered as tumor suppressor. The discovery of the replication fork remodeling activity of HLTF, particularly its fork reversal activity, provided a mechanistic explanation for its role in template switch dependent error-free DNA damage bypass. However, a stalled replication fork contains several single-stranded (ss) DNA- and dsDNA-bound proteins such as RPA, RFC, PCNA, and replicative polymerase. How these proteins are displaced before the DNA remodeling occurs has been unknown. Here we examine whether proteins bound to replication fork like DNA structures inhibit fork remodeling by two distinct fork reversal enzymes, namely HLTF, a Swi2/Snf2 family protein, and Blooms syndrome helicase (BLM), a RecQ family helicase. We provide evidence that HLTF can specifically remodel replication forks bound by either dsDNA- or ssDNA-binding proteins, which is associated with a novel protein remodeling activity of HLTF. These observations shed light on how masses of proteins surrounding the stalled replication fork can become displaced from the DNA providing thereby access to new damage bypass players

“The CRAB - Bucket Effect and Its Impact on Job Stress” – An Exploratory Study With Reference To Autonomous Colleges

Abstract--The World today is expanding and really competitive. For any person who is a victim of crab mentality ("Crab-Bucket Effect”), it’s a terrible stressor. Until now, whatever he/ she has been reputed for or worked hard for, are all in great jeopardy. The reason to popularize this social epidemic is to refer those people’s action of pulling others down, denigrating them rather than letting them get ahead or pursue their dreams. The study highlights on the distressed teachers in Autonomous colleges in Mangalore. In general, an accusation of having this type of mentality is a poor reflection of on someone’s personality. It creates neighborhood rivalry, chastising the people for not cooperating and leading to envy and competitive conspiracies at workplace. While the reason for crab mentality is thought to be jealousy, and a paucity of resources leading to perpetual competition, it also appears to be a behavioral trait indulged in despite people knowing it to be disadvantageous to them

Scaling Stress at Workplace and Its Impact on College Teachers: An Empirical Study

Stress is an unavoidable concept of life and work. It clearly describes the physical, emotional and mental wear and tear caused by the incongruence between the requirement of job and capabilities, needs and other resources to cope up with the job demands. Whatsoever, howsoever the situations are, hence it’s the responsibility of everyone to resolve it and create new ways of handling new situations at each life stage. For better understanding of these concepts, the researcher has carried out a Workplace Stress Survey in the cities of Chennai and Mangaluru, with respondents of three hundred college teachers approximately. Chennai, a metropolitan city and Mangaluru, a developing city on its own; really contributes towards the impact of stress on various employees. The purpose of the study is to ensure there is a higher impact of stress on teachers at college level, which is prominent in Chennai comparatively. For this study, a questionnaire was circulated among these respondents and calculations of stress levels were made on certain weights assigned to specific stress-factors. DOI: 10.17762/ijritcc2321-8169.15059

“Empathy Scaling and Its Impact on Employee’s Eustress” - A Study With Special Reference to Autonomous Colleges in Mangalore

In order to formulate a parsimonious tool to assess empathy, a self-report measure named Toronto Empathy Questionnaire (TEQ) is used. It demonstrates clearly the strong convergent validity, correlating positively with behavioural measures of social decoding exhibiting a good internal consistency and high test-retest reliability. In order to reach at accurate research conclusions, questions were re-worded to assess frequency of behavior rather than to pose general statements or tendencies. Responses were collected from a sample of hundred teachers from autonomous colleges in Mangalore city, and performances were ranked using a 5-point Likert-scale corresponding to various levels of frequency (i.e., never, rarely, sometimes, often, always. As the stress increases, we become less able to solve the real problems, costing billions of dollars, reducing the quality of life, driving economic meltdown and even destroying the environment (Distress). Hence, emotional competencies have proven to contribute more towards workplace productivity through the cognitive and social development of an individual (Eustress). DOI: 10.17762/ijritcc2321-8169.15020

Screening of new isolates of Bacillus thuringiensis (Bt) and cloning of the cry genes

Nine new indigenous isolates of Bacillus thuringiensis (Bt) were characterized for their colony type, crystal inclusion and toxicity analysis with Helicoverpa armigera Hubner and Spodoptera litura Linn. Genomic deoxyribonucleic acid (DNA) isolated from all the new isolates were subjected to screening for cry1, cry2, cry4, cry10 and cry11 genes and predicted possible potential DNA amplicons were cloned and sequenced. Partial cry1 gene fragment (~1.5 kb) amplified by degenerate primers and about 450 bp DNA fragment amplified by cry10 gene specific primers from two isolates T109 and T136 were cloned in to T/A cloning vector. DNA sequencing of about 1.5 kb amplicon showed 99% homology to the holotype sequence of cry1Ac1. Nucleotide sequence of about 450 bp fragments of isolate T109 and T136 showed homology to a hypothetical protein and serine/threonine phosphatase respectively.Keywords: Bacillus thuringiensis (Bt), cloning, cry genes, polymerase chain reaction (PCR), toxicity analysi

Electrochemical heavy metal detection, photocatalytic, photoluminescence, biodiesel production and antibacterial activities of Ag�ZnO nanomaterial

Zinc oxide nanoparticles (ZnO Nps) and silver doped zinc oxide nanoparticles (Ag�ZnO Nps) were prepared using nitrates of zinc and silver as oxidizers and succinic acid as a fuel through solution combustion synthesis (SCS) at 400 °C. The synthesized materials were characterized by various analytical techniques such as XRD, FTIR, Raman UV�vis, PL, SEM, EDX and TEM. The synthesized nanomaterials were tested for the photocatalytic degradation of methylene blue and the result reveal that Ag�ZnO Nps shows the better photocatalytic activity compared to undoped ZnO Nps. Biodiesel production from Simarouba oil shows that Ag�ZnO Nps acts as good catalyst compare to ZnO Nps, we have also developed sensor which showed a linearity in the concentration range 50�350 nM and limit of detection was found to be 3.5 and 3.8 nM (3�) for lead and cadmium respectively. Further we have examined the antibacterial activity against Escherichia coli and Staphylococcus aureus bacteria. © 2017 Elsevier Lt