20 research outputs found
Structure analysis of Zn-Mg-Ho icosahedral quasicrystal by modified Rietveld method using ellipsoid and sphere windows
A structure analysis of Zn-Mg-Ho icosahedral quasicrystal was carried out by
the powder X-ray diffraction method using synchrotron radiation (Lambda=0.73490
A) at SPring-8. The intensity distribution was analyzed by the Rietveld method
modified for an icosahedral quasicrystal, in which simplified models were
assumed: ellipsoid and spherical windows were assumed at five crystallographic
sites in a F-type hypercubic unit cell. The analysis revealed the presence of
an almost perfect Penrose tiling with edge length 5.20 A. The vertices are
occupied alternatively by Zn and Mg, and almost all of the edge centers of the
Penrose rhombohedra are occupied by 0.8Zn and 0.2Mg. Ho and Mg atoms tend to be
present on the body diagonal of the prolate rhombohedra. Good agreement between
the measured and calculated intensity distribution using the simplified model
suggests the applicability and the limitation of structure analysis using the
powder X-ray diffraction method.Comment: 10 pages, 3 tables, 3 figure
In vivo TSPO and cannabinoid receptor type 2 availability early in post-stroke neuroinflammation in rats: a positron emission tomography study
The Brain Activation Due to the High Frequency Non-Audible Sound, Study by PET and EEG for Young Middle-Aged People and Healthy Elderly
A Case of Pulmonary Pleomorphic Carcinoma With Renal Metastasis
A 62-year-old man was referred to our hospital for an axillary mass. Computed tomography (CT) revealed a right axillary tumor and a left renal tumor. Needle biopsies of lung tumor and renal tumor were performed, but a definite diagnosis was impossible. Because his performance status worsened and the lung tumor grew day by day, chemotherapy with gemcitabine and cisplatin was started without definite diagnosis. However, the chemotherapy could not be continued because of interstitial pneumonia and the patient died because of the progression of disease. The final histopathologic diagnosis was pulmonary pleomorphic carcinoma based on immunohistochemical staining
Androgen Receptor Splice Variant 7 Drives the Growth of Castration Resistant Prostate Cancer without Being Involved in the Efficacy of Taxane Chemotherapy
Expression of androgen receptor (AR) splice variant 7 (AR-V7) has been identified as the mechanism associated with the development of castration-resistant prostate cancer (CRPC). However, a potential link between AR-V7 expression and resistance to taxanes, such as docetaxel or cabazitaxel, has not been unequivocally demonstrated. To address this, we used LNCaP95-DR cells, which express AR-V7 and exhibit resistance to enzalutamide and docetaxel. Interestingly, LNCaP95-DR cells showed cross-resistance to cabazitaxel. Furthermore, these cells had increased levels of P-glycoprotein (P-gp) and their sensitivity to both docetaxel and cabazitaxel was restored through treatment with tariquidar, a P-gp antagonist. Results generated demonstrated that P-gp mediated cross-resistance between docetaxel and cabazitaxel. Although the LNCaP95-DR cells had increased expression of AR-V7 and its target genes (UBE2C, CDC20), the knockdown of AR-V7 did not restore sensitivity to docetaxel or cabazitaxel. However, despite resistance to docetaxel and carbazitaxel, EPI-002, an antagonist of the AR amino-terminal domain (NTD), had an inhibitory effect on the proliferation of LNCaP95-DR cells, which was similar to that achieved with the parental LNCaP95 cells. On the other hand, enzalutamide had no effect on the proliferation of either cell line. In conclusion, our results suggested that EPI-002 may be an option for the treatment of AR-V7-driven CRPC, which is resistant to taxanes
Oncological outcomes classified according to metastatic lesions in the era of molecular targeted drugs for metastatic renal cancer
A Case of Metastatic Urachal Carcinoma Treated With FOLFIRI (irinotecan and 5-Fluorouracil/leucovorin) Plus Bevacizumab
A 68-year-old man was introduced to our hospital for the treatment of lung and mediastinum lymph node metastases that originated from an urachal carcinoma 4 years after a partial cystectomy. First-line chemotherapy with an S-1 and cisplatin combination was ineffective. The patient received FOLFIRI plus bevacizumab chemotherapy as salvage chemotherapy. Stability was achieved after eight cycles of FOLFIRI plus bevacizumab therapy. We conducted a biopsy of the metastatic tumor, and the pathology of the biopsy tissue was partially necrotic. To our knowledge, this case represents the first report of a metastatic urachal carcinoma treated with FOLFIRI plus bevacizumab
Results of correlation coefficient between Δ[oxy-Hb] levels during the pre-task period and correct answer ratio in all channels.
<p>Correlation coefficient (ρ) values were presented.</p><p>*<i>P</i><0.05.</p
Results of the hemodynamic responses by two-way ANOVA in all channels.
<p>F values were presented. G×P, interaction between group and period.</p><p>*<i>P</i><0.05,</p><p>**<i>P</i><0.005.</p