566 research outputs found
New Matsushiro underground cosmic ray station (220 M.W.E. in depth)
A new underground cosmic ray station has been opened at Matsushiro, Japan, and a multidirectional (17 directional channels) muon telescope has been installed at an effective vertical depth of 220 m.w.e. The counting rates are; 8.7 x 10,000/hr for the wide vertical component and 2.0 x 10,000/hr for the vertical component. Continuous observation has been performed since March 22,1984. Some details of the telescope and preliminary analyzed results of the data are presented
Climatic responses of tree-ring widths of Larix gmelinii on contrasting north- and south-facing slopes in central Siberia
The original publication is available at www.springerlink.com.ArticleJournal of Wood Science. 53(2): 87-93 (2007)journal articl
Responses of ring widths and maximum densities of Larix gmelinii to climate on contrasting north- and south-facing slopes in central Siberia
The original publication is available at www.springerlink.com.ArticleEcological Research. 22(4):582-592 (2007)journal articl
Occurrence of sexual forms of the green peach aphid, Myzus persicae Sulz. in Kurashiki district
Stability of stationary solutions of the Schrodinger-Langevin equation
The stability properties of a class of dissipative quantum mechanical systems
are investigated. The nonlinear stability and asymptotic stability of
stationary states (with zero and nonzero dissipation respectively) is
investigated by Liapunov's direct method. The results are demonstrated by
numerical calculations on the example of the damped harmonic oscillator.Comment: revised, 12 pages, 7 figure
A Pilot Study of Human Interferon beta Gene Therapy for Patients with Advanced Melanoma by in vivo Transduction Using Cationic Liposomes
This is a pre-copy-editing, auyhor-produced PDF of an article forpublication in JAPANESE JOURNAL OF CLINICAL ONCOLOGY following peer review. The definitive publisher-authenticated version JAPANESE JOURNAL OF CLINICAL ONCOLOGY. 38(12):849-856 (2008) is available online at 10.1093/jjco/hyn114JAPANESE JOURNAL OF CLINICAL ONCOLOGY. 38(12):849-856 (2008)journal articl
Fgf10-CRISPR mosaic mutants demonstrate the gene dose-related loss of the accessory lobe and decrease in the number of alveolar type 2 epithelial cells in mouse lung
CRISPR/Cas9-mediated gene editing often generates founder generation (F0) mice that exhibit somatic mosaicism in the targeted gene(s). It has been known thatFibroblast growth factor 10(Fgf10)-null mice exhibit limbless and lungless phenotypes, while intermediate limb phenotypes (variable defective limbs) are observed in theFgf10-CRISPR F0 mice. However, how the lung phenotype in theFgf10-mosaic mutants is related to the limb phenotype and genotype has not been investigated. In this study, we examined variable lung phenotypes in theFgf10-targeted F0 mice to determine if the lung phenotype was correlated with percentage of functionalFgf10genotypes. Firstly, according to a previous report,Fgf10-CRISPR F0 embryos on embryonic day 16.5 (E16.5) were classified into three types: type I, no limb; type II, limb defect; and type III, normal limbs. Cartilage and bone staining showed that limb truncations were observed in the girdle, (type I), stylopodial, or zeugopodial region (type II). Deep sequencing of theFgf10-mutant genomes revealed that the mean proportion of codons that encode putative functional FGF10 was 8.3 +/- 6.2% in type I, 25.3 +/- 2.7% in type II, and 54.3 +/- 9.5% in type III (mean +/- standard error of the mean) mutants at E16.5. Histological studies showed that almost all lung lobes were absent in type I embryos. The accessory lung lobe was often absent in type II embryos with other lobes dysplastic. All lung lobes formed in type III embryos. The number of terminal tubules was significantly lower in type I and II embryos, but unchanged in type III embryos. To identify alveolar type 2 epithelial (AECII) cells, known to be reduced in theFgf10-heterozygous mutant, immunostaining using anti-surfactant protein C (SPC) antibody was performed: In the E18.5 lungs, the number of AECII was correlated to the percentage of functionalFgf10genotypes. These data suggest theFgf10gene dose-related loss of the accessory lobe and decrease in the number of alveolar type 2 epithelial cells in mouse lung. Since dysfunction of AECII cells has been implicated in the pathogenesis of parenchymal lung diseases, theFgf10-CRISPR F0 mouse would present an ideal experimental system to explore it
Lung of Fgf10-CRISPR mosaic mouse
CRISPR/Cas9-mediated gene editing often generates founder generation (F0) mice that exhibit somatic mosaicism in the targeted gene(s). It has been known that Fibroblast growth factor 10 (Fgf10)-null mice exhibit limbless and lungless phenotypes, while intermediate limb phenotypes (variable defective limbs) are observed in the Fgf10-CRISPR F0 mice. However, how the lung phenotype in the Fgf10-mosaic mutants is related to the limb phenotype and genotype has not been investigated. In this study, we examined variable lung phenotypes in the Fgf10-targeted F0 mice to determine if the lung phenotype was correlated with percentage of functional Fgf10 genotypes. Firstly, according to a previous report, Fgf10-CRISPR F0 embryos on embryonic day 16.5 (E16.5) were classified into three types: type I, no limb; type II, limb defect; and type III, normal limbs. Cartilage and bone staining showed that limb truncations were observed in the girdle, (type I), stylopodial, or zeugopodial region (type II). Deep sequencing of the Fgf10-mutant genomes revealed that the mean proportion of codons that encode putative functional FGF10 was 8.3 ± 6.2% in type I, 25.3 ± 2.7% in type II, and 54.3 ± 9.5% in type III (mean ± standard error of the mean) mutants at E16.5. Histological studies showed that almost all lung lobes were absent in type I embryos. The accessory lung lobe was often absent in type II embryos with other lobes dysplastic. All lung lobes formed in type III embryos. The number of terminal tubules was significantly lower in type I and II embryos, but unchanged in type III embryos. To identify alveolar type 2 epithelial (AECII) cells, known to be reduced in the Fgf10-heterozygous mutant, immunostaining using anti-surfactant protein C (SPC) antibody was performed: In the E18.5 lungs, the number of AECII was correlated to the percentage of functional Fgf10 genotypes. These data suggest the Fgf10 gene dose-related loss of the accessory lobe and decrease in the number of alveolar type 2 epithelial cells in mouse lung. Since dysfunction of AECII cells has been implicated in the pathogenesis of parenchymal lung diseases, the Fgf10-CRISPR F0 mouse would present an ideal experimental system to explore it
Neutrino Mixing and Neutrino Telescopes
Measuring flux ratios of ultra-high energy neutrinos is an alternative method
to determine the neutrino mixing angles and the CP phase delta. We conduct a
systematic analysis of the neutrino mixing probabilities and of various flux
ratios measurable at neutrino telescopes. The considered cases are neutrinos
from pion, neutron and muon-damped sources. Explicit formulae in case of mu-tau
symmetry and its special case tri-bimaximal mixing are obtained, and the
leading corrections due to non-zero theta_{13} and non-maximal theta_{23} are
given. The first order correction is universal as it appears in basically all
ratios. We study in detail its dependence on theta_{13}, theta_{23} and the CP
phase, finding that the dependence on theta_{23} is strongest. The flavor
compositions for the considered neutrino sources are evaluated in terms of this
correction. A measurement of a flux ratio is a clean measurement of the
universal correction (and therefore of theta_{13}, theta_{23} and delta) if the
zeroth order ratio does not depend on theta_{12}. This favors pion sources over
the other cases, which in turn are good candidates to probe theta_{12}. The
only situations in which the universal correction does not appear are certain
ratios in case of a neutron and muon-damped source, which depend mainly on
theta_{12} and receive only quadratic corrections from the other parameters. We
further show that there are only two independent neutrino oscillation
probabilities, give the allowed ranges of the considered flux ratios and of all
probabilities, and show that none of the latter can be zero or one.Comment: 29 pages, 8 figures. Minor changes, to appear in JCA
- …