Verrucous carcinoma arising in an extended giant condyloma acuminatum (Buschke–Löwenstein tumor): a case report and review of the literature

INTRODUCTION: Verrucous carcinoma of the external genitalia and perianal region is a rare variant of well-differentiated squamous cell carcinoma. It has been reported to have limited metastatic potential. CASE PRESENTATION: We report the case of a 54 year-old Moroccan man who presented with locally advanced giant condyloma acuminatum (Buschke–Löwenstein tumor) after prolonged intervals of neglect (approximately 10 years). The disease covered his suprapubic, external genitalia and perianal region. It was locally aggressive with extensive tissue destruction. After a biopsy of the lesion, the diagnosis of verrucous carcinoma was confirmed. He initially received chemoradiotherapy, followed by extensive local excision, but he developed septic shock and died a few days later. CONCLUSIONS: The purpose of this case report is to present a case of verrucous carcinoma arising in an extensive giant condyloma acuminatum (Buschke–Löwenstein tumor) and discuss the literature on its diagnosis and management

A Hybrid Algorithm for Optimal Wireless Sensor Network Deployment with the Minimum Number of Sensor Nodes

Wireless sensor network (WSN) applications are rapidly growing and are widely used in various disciplines. Deployment is one of the key issues to be solved in WSNs, since the sensor nodes’ positioning affects highly the system performance. An optimal WSN deployment should maximize the collection of the desired interest phenomena, guarantee the required coverage and connectivity, extend the network lifetime, and minimize the network cost in terms of energy consumption. Most of the research effort in this area aims to solve the deployment issue, without minimizing the network cost by reducing unnecessary working nodes in the network. In this paper, we propose a deployment approach based on the gradient method and the Simulated Annealing algorithm to solve the sensor deployment problem with the minimum number of sensor nodes. The proposed algorithm is able to heuristically optimize the number of sensors and their positions in order to achieve the desired application requirements

Automatic control system for managing travel certificates and monitoring the spread of Covid-19 pandemic in Morocco

The automatic control system for managing mobility certificates during the Covid-19 pandemic in Morocco "ACS-MMC", is a platform, developed so citizens can apply on line for mobility and travel certificates during the curfew of health emergency, caused by Covid-19 in Morocco.  The platform goal was minimising citizens’ contact with agents of the law forces and the public administration by designing the application process on line and generating digital certifacates for mobility. Besides, "ACS-MMC" system proposed mobility control to be performed at the authorities’ checkpoints since the certificate’ QR code can be easily shared between smartphones. Moreover, the system summarized the spread of the infection through its dynamic dashboard that indicated infected cases and movements traceability at the national level, in order to take all necessary precautions to limit as much as possible a large contamination of the population. This project was funded by NCSTR (National Center for Scientific and Technical Research in Morocco) and Abdelmalek Essaadi University (Morocco)

Automatic control system for managing travel certificates and monitoring the spread of Covid-19 pandemic in Morocco

The automatic control system for managing mobility certificates during the Covid-19 pandemic in Morocco "ACS-MMC", is a platform, developed so citizens can apply on line for mobility and travel certificates during the curfew of health emergency, caused by Covid-19 in Morocco.  The platform goal was minimising citizens’ contact with agents of the law forces and the public administration by designing the application process on line and generating digital certifacates for mobility. Besides, "ACS-MMC" system proposed mobility control to be performed at the authorities’ checkpoints since the certificate’ QR code can be easily shared between smartphones. Moreover, the system summarized the spread of the infection through its dynamic dashboard that indicated infected cases and movements traceability at the national level, in order to take all necessary precautions to limit as much as possible a large contamination of the population. This project was funded by NCSTR (National Center for Scientific and Technical Research in Morocco) and Abdelmalek Essaadi University (Morocco)

pydantic/pydantic: v2.5.2 2023-11-22

<h2>v2.5.2 (2023-11-22)</h2> <p><a href="https://github.com/pydantic/pydantic/releases/tag/v2.5.2">GitHub release</a></p> <h3>What's Changed</h3> <h4>Packaging</h4> <ul> <li>uprev <code>pydantic-core</code> to 2.14.5</li> </ul> <h4>New Features</h4> <ul> <li>Add <code>ConfigDict.ser_json_inf_nan</code> by @davidhewitt in <a href="https://github.com/pydantic/pydantic/pull/8159">#8159</a></li> </ul> <h4>Fixes</h4> <ul> <li>Fix validation of <code>Literal</code> from JSON keys when used as <code>dict</code> key by @sydney-runkle in <a href="https://github.com/pydantic/pydantic-core/pull/1075">pydantic/pydantic-core#1075</a></li> <li>Fix bug re <code>custom_init</code> on members of <code>Union</code> by @sydney-runkle in <a href="https://github.com/pydantic/pydantic-core/pull/1076">pydantic/pydantic-core#1076</a></li> <li>Fix <code>JsonValue</code> <code>bool</code> serialization by @sydney-runkle in <a href="https://github.com/pydantic/pydantic/pull/8159">#8190</a></li> <li>Fix handling of unhashable inputs with <code>Literal</code> in <code>Union</code>s by @sydney-runkle in <a href="https://github.com/pydantic/pydantic-core/pull/1089">pydantic/pydantic-core#1089</a></li> </ul> <p>https://github.com/pydantic/pydantic/compare/v2.5.1...v2.5.2/</p&gt

Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region.

International audienceOnly a small fraction of individuals infected with Mycobacterium tuberculosis develop clinical tuberculosis (TB) in their lifetime. Genetic epidemiological evidence suggests a genetic determinism of pulmonary TB (PTB), but the molecular basis of genetic predisposition to PTB remains largely unknown. We used a positional-cloning approach to carry out ultrafine linkage-disequilibrium mapping of a previously identified susceptibility locus in chromosomal region 8q12-13 by genotyping 3,216 SNPs in a family-based Moroccan sample including 286 offspring with PTB. We observed 44 PTB-associated SNPs (p < 0.01), which were genotyped in an independent set of 317 cases and 650 controls from Morocco. A single signal, consisting of two correlated SNPs close to TOX, rs1568952 and rs2726600 (combined p = 1.1 × 10(-5) and 9.2 × 10(-5), respectively), was replicated. Stronger evidence of association was found in individuals who developed PTB before the age of 25 years (combined p for rs1568952 = 4.4 × 10(-8); odds ratio of PTB for AA versus AG/GG = 3.09 [1.99-4.78]). The association with rs2726600 (p = 0.04) was subsequently replicated in PTB-affected subjects under 25 years in a study of 243 nuclear families from Madagascar. Stronger evidence of replication in Madagascar was obtained for additional SNPs in strong linkage disequilibrium with the two initial SNPs (p = 0.003 for rs2726597), further confirming the signal. We thus identified around rs1568952 and rs2726600 a cluster of SNPs strongly associated with early-onset PTB in Morocco and Madagascar. SNP rs2726600 is located in a transcription-factor binding site in the 3' region of TOX, and further functional explorations will focus on CD4 T lymphocytes

pydantic/pydantic: v2.5.1 2023-11-15

&lt;h2&gt;v2.5.1 (2023-11-15)&lt;/h2&gt; &lt;p&gt;&lt;a href="https://github.com/pydantic/pydantic/releases/tag/v2.5.1"&gt;GitHub release&lt;/a&gt;&lt;/p&gt; &lt;h3&gt;What's Changed&lt;/h3&gt; &lt;h4&gt;Packaging&lt;/h4&gt; &lt;ul&gt; &lt;li&gt;uprev pydantic-core to 2.14.3 by @samuelcolvin in &lt;a href="https://github.com/pydantic/pydantic/pull/8120"&gt;#8120&lt;/a&gt;&lt;/li&gt; &lt;/ul&gt; &lt;h4&gt;Fixes&lt;/h4&gt; &lt;ul&gt; &lt;li&gt;Fix package description limit by @dmontagu in &lt;a href="https://github.com/pydantic/pydantic/pull/8097"&gt;#8097&lt;/a&gt;&lt;/li&gt; &lt;li&gt;Fix &lt;code&gt;ValidateCallWrapper&lt;/code&gt; error when creating a model which has a @validate_call wrapped field annotation by @sydney-runkle in &lt;a href="https://github.com/pydantic/pydantic/pull/8110"&gt;#8110&lt;/a&gt;&lt;/li&gt; &lt;/ul&gt; &lt;p&gt;Full Changelog: https://github.com/pydantic/pydantic/compare/v2.5.0...v2.5.1/&lt;/p&gt