Association of high myopia with crystallin beta A4 (CRYBA4) gene polymorphisms in the linkage-identified MYP6 locus

Author name used in this publication: Maurice K. H. Yap2011-2012 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Genetic susceptibility to refractive error : association of vasoactive intestinal peptide receptor 2 (VIPR2) with high myopia in Chinese

Author name used in this publication: Maurice K. H. Yap2012-2013 > Academic research: refereed > Publication in refereed journalpublished_fina

Evaluation of proteoglycan gene polymorphisms as risk factors in the genetic susceptibility to high myopia

Author name used in this manuscript: Maurice K. H. Yap2011-2012 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

A DNA pooling-based case-control study of myopia candidate genes COL11A1, COL18A1, FBN1, and PLOD1 in a Chinese population

Author name used in this publication: Maurice K. H. Yap2010-2011 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Genotyping performance assessment of whole genome amplified DNA with respect to multiplexing level of assay and its period of storage

Author name used in this publication: Maurice K. H. Yap2011-2012 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Systematic investigation of the relationship between high myopia and polymorphisms of the MMP₂, TIMP₂, and TIMP₃ genes by a DNA pooling approach

Author name used in this manuscript: Maurice K. H. Yap2010-2011 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Linkage and association of myocilin (MYOC) polymorphisms with high myopia in a Chinese population

Author name used in this publication: Maurice K.H. Yap2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability