Antifungal potential of extracts, fractions and compounds from Uvaria comperei (Annonaceae) and Oxyanthus unilocularis (Rubiaceae)

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Chemical constituents from root barks of Erythrina mildbraedii and stem barks of Erythrina addisoniae

The β-D-galactopyranoside of the tetracosanoic acid (1) was isolated from the stem barks of Erythrina addisoniae along with known tetracosanoic acid (2), α-sophoradiol (3), stigmasterol (4), warangalone (5), 3-Oβ-D-glucopyranoside of β-sitosterol (6) and 7-O-β-D-glucopyranoside of daidzein (7). Two known compounds (erythrinasinate (8) and erycristagallin (9)) were also isolated from the root barks of Erythrina mildbraedii. Their structures were assigned on the basis of spectroscopic data and chemical transformation. DOI: http://dx.doi.org/10.4314/bcse.v28i1.1

Antidiabetic properties of the methanolic extract of Bridelia grandis (Euphorbiacae) in ob/ob and db/db mice

Bridelia grandis is used in most parts of tropical Africa for the treatment of diabetes. The anti-diabetic properties of the methanolic stem bark extract of this plant was studied in ob/ob and db/db mice. The plant extract induced hypoglycaemic effects of long duration in the ob/ob mice, while its effects were less pronounced in the db/db mice. Twenty four hours after the cessation of drug administration, both ob/ob and db/db extract treated animals still had significantly lower fasting blood sugar levels when compared to controls, thus confirming its antidiabetic properties.Key words: Bridelia grandis (Euphorbiaceae), antidiabetic properties, ob/ob and db/db mice

Further isoflavonoid metabolites from Millettia griffoniana (Bail)

Three new isoflavonoids, griffonianone A (1), B (2) and C (4) were isolated from the root bark of Millettia griffoniama, along with the known maximaisoflavone G (5) and 7-hydroxy-6- methoxy-3',4'-methylenedioxyisoflavone (6). Their structures were assi

Identification of an anti-inflammatory principle from the stem bark of Millettia versicolor

The dichloromethane-soluble fraction of the methanol extract of the stem bark of Millettia versicolor Welw. (Leguminosae) has been shown to possess anti-inflammatory activity. The chromatographic fractionation and subsequent analysis of the spectroscopic data of this extract led to the isolation and identification of 2-acetyl-7-methoxynaphtho[2,3-b]furan-4,9-quinone (1) along with two known quinones. Pharmacological data demonstrate that compound 1 has relevant anti-inflammatory properties whereas the other two isolated compounds do not

Caeruleanone A, a Rotenoid with a New Arrangement of the D-Ring from the Fruits of Millettia caerulea

[Image: see text] Caeruleanone A (1), a novel rotenoid with an unprecedented arrangement of the D-ring, was isolated with another two new analogues, caeruleanones B (2) and C (3), together with 11 known rotenoids from the fruits of Millettia caerulea. The structures of the new compounds were determined by spectroscopic data analysis, with that of 1 being confirmed by single-crystal X-ray diffraction. Compounds 2 and 3 displayed potent mitochondrial transmembrane potential inhibitory and quinone reductase induction activities