Molecular evolution of the sheep prion protein gene

Transmissible spongiform encephalopathies (TSEs) are infectious, fatal neurodegenerative diseases characterized by aggregates of modified forms of the prion protein (PrP) in the central nervous system. Well known examples include variant Creutzfeldt-Jakob Disease (vCJD) in humans, BSE in cattle, chronic wasting disease in deer and scrapie in sheep and goats. In humans, sheep and deer, disease susceptibility is determined by host genotype at the prion protein gene (PRNP). Here I examine the molecular evolution of PRNP in ruminants and show that variation in sheep appears to have been maintained by balancing selection, a profoundly different process from that seen in other ruminants. Scrapie eradication programs such as those recently implemented in the UK, USA and elsewhere are based on the assumption that PRNP is under positive selection in response to scrapie. If, as these data suggest, that assumption is wrong, eradication programs will disrupt this balancing selection, and may have a negative impact on the fitness or scrapie resistance of national flocks

Non-diagonal solutions of the reflection equation for the trigonometric An−1(1)A^{(1)}_{n-1} vertex model

We obtain a class of non-diagonal solutions of the reflection equation for the trigonometric $A^{(1)}_{n-1}$ vertex model. The solutions can be expressed in terms of intertwinner matrix and its inverse, which intertwine two trigonometric R-matrices. In addition to a {\it discrete} (positive integer) parameter $l$, $1\leq l\leq n$, the solution contains $n+2$ {\it continuous} boundary parameters.Comment: Latex file, 14 pages; V2, minor typos corrected and a reference adde

On the second reference state and complete eigenstates of the open XXZ chain

The second reference state of the open XXZ spin chain with non-diagonal boundary terms is studied. The associated Bethe states exactly yield the second set of eigenvalues proposed recently by functional Bethe Ansatz. In the quasi-classical limit, two sets of Bethe states give the complete eigenstates of the associated Gaudin model.Comment: Latex file, 12 pages; New version appears in JHE

High performance Beowulf computer for lattice QCD

We describe the construction of a high performance parallel computer composed of PC components, as well as the performance test in lattice QCD.Comment: Lattice 2001 (Algorithms and Machines) 3 page

Finite-temperature perturbation theory for quasi-one-dimensional spin-1/2 Heisenberg antiferromagnets

We develop a finite-temperature perturbation theory for quasi-one-dimensional quantum spin systems, in the manner suggested by H.J. Schulz (1996) and use this formalism to study their dynamical response. The corrections to the random-phase approximation formula for the dynamical magnetic susceptibility obtained with this method involve multi-point correlation functions of the one-dimensional theory on which the random-phase approximation expansion is built. This ``anisotropic'' perturbation theory takes the form of a systematic high-temperature expansion. This formalism is first applied to the estimation of the N\'eel temperature of S=1/2 cubic lattice Heisenberg antiferromagnets. It is then applied to the compound Cs$_2$CuCl$_4$, a frustrated S=1/2 antiferromagnet with a Dzyaloshinskii-Moriya anisotropy. Using the next leading order to the random-phase approximation, we determine the improved values for the critical temperature and incommensurability. Despite the non-universal character of these quantities, the calculated values are different by less than a few percent from the experimental values for both compounds.Comment: 11 pages, 6 figure

ZnZ_n elliptic Gaudin model with open boundaries

The $Z_n$ elliptic Gaudin model with integrable boundaries specified by generic non-diagonal K-matrices with $n+1$ free boundary parameters is studied. The commuting families of Gaudin operators are diagonalized by the algebraic Bethe ansatz method. The eigenvalues and the corresponding Bethe ansatz equations are obtained.Comment: 21 pages, Latex fil

Game prototype for understanding safety issues of life boat launching process.

Novel advanced game techniques provide us with new possibilities to mimic a complicated training process, with the benefit of safety enhancement. In this paper, we design and implement a 3D game which imitates the lifeboat launching process. Lifeboat launching is such a complex but vital process which can on one side saving people's life on sea and on the other side associating many potential hazards. It involves both the tractor manoeuvres and boat operations. The primary objective of the game is to allow novices to better understand the sequence of the operations in launching process and manager the potential hazards happening during the launching. There is also great educational significance with the promotion of the game to the general public for enhanced awareness of safety issues. The key modules of the game are designed based on physical simulation which gives the players enhanced plausible cognition and enjoyable interaction

Drinfeld Twists and Algebraic Bethe Ansatz of the Supersymmetric t-J Model

We construct the Drinfeld twists (factorizing $F$-matrices) for the supersymmetric t-J model. Working in the basis provided by the $F$-matrix (i.e. the so-called $F$-basis), we obtain completely symmetric representations of the monodromy matrix and the pseudo-particle creation operators of the model. These enable us to resolve the hierarchy of the nested Bethe vectors for the $gl(2|1)$ invariant t-J model.Comment: 23 pages, no figure, Latex file, minor misprints are correcte

Coulomb Gaps in One-Dimensional Spin-Polarized Electron Systems

We investigate the density of states (DOS) near the Fermi energy of one-dimensional spin-polarized electron systems in the quantum regime where the localization length is comparable to or larger than the inter-particle distance. The Wigner lattice gap of such a system, in the presence of weak disorder, can occur precisely at the Fermi energy, coinciding with the Coulomb gap in position. The interplay between the two is investigated by treating the long-range Coulomb interaction and the random disorder potential in a self-consistent Hartree-Fock approximation. The DOS near the Fermi energy is found to be well described by a power law whose exponent decreases with increasing disorder strength.Comment: 4 pages, revtex, 4 figures, to be published in Phys. Rev. B as a Rapid Communicatio

QFT on homothetic Killing twist deformed curved spacetimes

We study the quantum field theory (QFT) of a free, real, massless and curvature coupled scalar field on self-similar symmetric spacetimes, which are deformed by an abelian Drinfel'd twist constructed from a Killing and a homothetic Killing vector field. In contrast to deformations solely by Killing vector fields, such as the Moyal-Weyl Minkowski spacetime, the equation of motion and Green's operators are deformed. We show that there is a *-algebra isomorphism between the QFT on the deformed and the formal power series extension of the QFT on the undeformed spacetime. We study the convergent implementation of our deformations for toy-models. For these models it is found that there is a *-isomorphism between the deformed Weyl algebra and a reduced undeformed Weyl algebra, where certain strongly localized observables are excluded. Thus, our models realize the intuitive physical picture that noncommutative geometry prevents arbitrary localization in spacetime.Comment: 23 pages, no figures; v2: extended discussion of physical consequences, compatible with version to be published in General Relativity and Gravitatio