Arbitrary super surface modes bounded by multilayered metametal

The dispersion of the fundamental super mode confined along the boundary between a multilayer metal-insulator (MMI) stack and a dielectric coating is theoretically analyzed and compared to the dispersion of surface waves on a single metal-insulator (MI) boundary. Based on the classical Kretschmann setup, the MMI system is experimentally tested as an anisotropic material to exhibit plasmonic behavior and a candidate of “metametal” to engineer the preset surface plasmon frequency of conventional metals for optical sensing applications. The conditions to obtain artificial surface plasmon frequency are thoroughly studied, and the tuning of surface plasmon frequency is verified by electromagnetic modeling and experiments. The design rules drawn in this paper would bring important insights into applications such as optical lithography, nano-sensing and imaging

Electrochemical Insertion/extraction of Lithium in Multiwall Carbon Nanotube/Sb and SnSb₀.₅ Nanocomposites

Multiwall carbon nanotubes (CNTs) were synthesized by catalytic chemical vapor deposition of acetylene and used as templates to prepare CNT-Sb and CNT-SnSb₀.₅ nanocomposites via the chemical reduction of SnCl₂ and SbCl₃ precursors. SEM and TEM imagings show that the Sb and SnSb₀.₅ particles were uniformly dispersed in the CNT web and on the outside surface of CNTs. These CNT-metal composites are active anode materials for lithium ion batteries, showing improved cyclability compared to unsupported Sb and SnSb particles; and higher reversible specific capacities than CNTs. The improvement in cyclability may be attributed to the nanoscale dimensions of the metal particles and CNT’s role as a buffer in containing the mechanical stress arising from the volume changes in electrochemical lithium insertion and extraction reactions.Singapore-MIT Alliance (SMA

Clinical Progress of Acupuncture in the Treatment of ACL after Reconstructive Surgery

Anterior cruciate ligament (ACL) injury of the knee is one of the common sports injuries, and ACL reconstruction is currently the mainstream treatment. However,ACL reconstruction often produces postoperative complications such as swelling, pain, muscle atrophy, joint adhesion and stifness, and timely interventional rehabilitation is needed for patients to recover the expected level. Studies have shown that acupuncture treatment can regulate infammatory factors and related signalling pathways, etc., and has obvious efcacy in joint rehabilitation after ACL reconstruction. The authors collated clinical reports on the use of acupuncture therapy such as general acupuncture, electroacu-puncture, moxibustion with acupuncture, snap needling, and ethnic acupuncture in the rehabilitation process after ACL reconstruction in re-cent years, to explore the feasibility and efectiveness of the intervention of acupuncture therapy, with the aim of providing a more systematic reference for the treatment ofACL injury in the future clinic after surgery

ControlRec: Bridging the Semantic Gap between Language Model and Personalized Recommendation

The successful integration of large language models (LLMs) into recommendation systems has proven to be a major breakthrough in recent studies, paving the way for more generic and transferable recommendations. However, LLMs struggle to effectively utilize user and item IDs, which are crucial identifiers for successful recommendations. This is mainly due to their distinct representation in a semantic space that is different from the natural language (NL) typically used to train LLMs. To tackle such issue, we introduce ControlRec, an innovative Contrastive prompt learning framework for Recommendation systems. ControlRec treats user IDs and NL as heterogeneous features and encodes them individually. To promote greater alignment and integration between them in the semantic space, we have devised two auxiliary contrastive objectives: (1) Heterogeneous Feature Matching (HFM) aligning item description with the corresponding ID or user's next preferred ID based on their interaction sequence, and (2) Instruction Contrastive Learning (ICL) effectively merging these two crucial data sources by contrasting probability distributions of output sequences generated by diverse tasks. Experimental results on four public real-world datasets demonstrate the effectiveness of the proposed method on improving model performance.Comment: 11 pages, 7 figure

Concomitant preoperative airflow obstruction confers worse prognosis after trans-thoracic surgery for esophageal cancer

BackgroundAirflow obstruction is a critical element of chronic airway diseases. This study aimed to evaluate the impact of preoperative airflow obstruction on the prognosis of patients following surgery for esophageal carcinoma.MethodsA total of 821 esophageal cancer patients were included and classified into two groups based on whether or not they had preoperative airflow obstruction. Airflow obstruction was defined as a forced expiration volume in the first second (FEV1)/forced vital capacity (FVC) ratio below the lower limit of normal (LLN). A retrospective analysis of the impact of airflow obstruction on the survival of patients with esophageal carcinoma undergoing esophagectomy was performed.ResultsPatients with airflow obstruction (102/821, 12.4%) had lower three-year overall (42/102, 58.8%) and progression-free survival rate (47/102, 53.9%) than those without airflow obstruction (P < 0.001). Multivariate analyses showed that airflow obstruction was an independent risk factor for overall survival (Hazard Ratio = 1.66; 95% CI: 1.17–2.35, P = 0.004) and disease progression (Hazard Ratio = 1.51; 95% CI: 1.1–2.08; P = 0.01). A subgroup analysis revealed that the above results were more significant in male patients, BMI < 23 kg/m2 patients or late-stage cancer (stage III-IVA) (P = 0.001) patients and those undergoing open esophagectomy (P < 0.001).ConclusionPreoperative airflow obstruction defined by FEV1/FVC ratio below LLN was an independent risk factor for mortality in esophageal cancer patients after trans-thoracic esophagectomy. Comprehensive management of airflow obstruction and more personalized surgical decision-making are necessary to improve survival outcomes in esophageal cancer patients

Health diagnosis and recuperation of aged Li-ion batteries with data analytics and equivalent circuit modeling

Battery health assessment and recuperation play a crucial role in the utilization of second-life Li-ion batteries. However, due to ambiguous aging mechanisms and lack of correlations between the recovery effects and operational states, it is challenging to accurately estimate battery health and devise a clear strategy for cell rejuvenation. This paper presents aging and reconditioning experiments of 62 commercial high-energy type lithium iron phosphate (LFP) cells, which supplement existing datasets of high-power LFP cells. The relatively large-scale data allow us to use machine learning models to predict cycle life and identify important indicators of recoverable capacity. Considering cell-to-cell inconsistencies, an average test error of $16.84\% \pm 1.87\%$ (mean absolute percentage error) for cycle life prediction is achieved by gradient boosting regressor given information from the first 80 cycles. In addition, it is found that some of the recoverable lost capacity is attributed to the lateral lithium non-uniformity within the electrodes. An equivalent circuit model is built and experimentally validated to demonstrate how such non-uniformity can be accumulated, and how it can give rise to recoverable capacity loss. SHapley Additive exPlanations (SHAP) analysis also reveals that battery operation history significantly affects the capacity recovery.Comment: 20 pages, 5 figures, 1 tabl

Insertion of a TRIM-like sequence in MdFLS2-1 promoter is associated with its allele-specific expression in response to Alternaria alternata in apple

Alternaria blotch disease, caused by Alternaria alternata apple pathotype (AAAP), is one of the major fungal diseases in apple. Early field observations revealed, the anther-derived homozygote Hanfu line (HFTH1) was highly susceptible to AAAP, whereas Hanfu (HF) exhibited resistance to AAAP. To understand the molecular mechanisms underlying the difference in sensitivity of HF and HFTH1 to AAAP, we performed allele-specific expression (ASE) analysis and comparative transcriptomic analysis before and after AAAP inoculation. We reported an important immune gene, namely, MdFLS2, which displayed strong ASE in HF with much lower expression levels of HFTH1-derived alleles. Transient overexpression of the dominant allele of MdFLS2-1 from HF in GL-3 apple leaves could enhance resistance to AAAP and induce expression of genes related to salicylic acid pathway. In addition, MdFLS2-1 was identified with an insertion of an 85-bp terminal-repeat retrotransposon in miniature (TRIM) element-like sequence in the upstream region of the nonreference allele. In contrast, only one terminal direct repeat (TDR) from TRIM-like sequence was present in the upstream region of the HFTH1-derived allele MdFLS2-2. Furthermore, the results of luciferase and β-glucuronidase reporter assays demonstrated that the intact TRIM-like sequence has enhancer activity. This suggested that insertion of the TRIM-like sequence regulates the expression level of the allele of MdFLS2, in turn, affecting the sensitivity of HF and HFTH1 to AAAP

Fly piRNA biogenesis: tap dancing with Tej

Piwi-interacting RNAs (piRNAs) protect animal germlines from the deleterious effects of transposon activity. Unlike other small RNA classes like microRNAs (miRNAs) and small interfering RNAs (siRNAs), an exceptionally large number of factors are implicated in the biogenesis of piRNAs. Kai et al. have now added another one to this growing list, which we discuss in the overall context of our current knowledge of the piRNA biogenesis pathway in the Drosophila ovarian germline. See research article: http://www.biomedcentral.com/1741-7007/12/61

SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia

Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we use domain-focused CRISPR screening and identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Using CRISPR exon scanning and gene complementation assays, we show that the catalytic function of SCP4 is essential in AML. Through mass spectrometry analysis of affinity-purified complexes, we identify the kinase paralogs STK35 and PDIK1L as binding partners and substrates of the SCP4 phosphatase domain. We show that STK35 and PDIK1L function catalytically and redundantly in the same pathway as SCP4 to maintain AML proliferation and to support amino acid biosynthesis and transport. We provide evidence that SCP4 regulates STK35/PDIK1L through two distinct mechanisms: catalytic removal of inhibitory phosphorylation and by promoting kinase stability. Our findings reveal a phosphatase-kinase signaling complex that supports the pathogenesis of AML

SLC5A3-dependent myo-inositol auxotrophy in acute myeloid leukemia.

An enhanced requirement for nutrients is a hallmark property of cancer cells. Here, we optimized an in vivo genetic screening strategy in acute myeloid leukemia (AML), which led to the identification of the myo-inositol transporter SLC5A3 as a dependency in this disease. We demonstrate that SLC5A3 is essential to support a myo-inositol auxotrophy in AML. The commonality among SLC5A3-dependent AML lines is the transcriptional silencing of ISYNA1, which encodes the rate limiting enzyme for myo-inositol biosynthesis, inositol-3-phosphate synthase 1. We use gain- and loss-of-function experiments to reveal a synthetic lethal genetic interaction between ISYNA1 and SLC5A3 in AML, which function redundantly to sustain intracellular myo-inositol. Transcriptional silencing and DNA hyper-methylation of ISYNA1 occur in a recurrent manner in human AML patient samples, in association with IDH1/IDH2 and CEBPA mutations. Our findings reveal myo-inositol as a nutrient dependency in AML caused by the aberrant silencing of a biosynthetic enzyme