Tetra-μ-acetato-κ8 O:O′-bis­{[2-methyl­sulfanyl-4-(pyridin-4-yl-κN)pyrimidine]­copper(II)}(Cu—Cu)

The binuclear title compound, [Cu2(CH3CO2)4(C10H9N3S)2], comprises a Cu2(CH3CO2)4 paddle-wheel core axially bound by two 2-methyl­sulfanyl-4-(pyridin-4-yl)pyrimidine ligands. The complex mol­ecule has an inversion center lying at the mid-point of the Cu—Cu bond

品管圈活动在手术室低年资护士管理中的促进作用

By comparing the participation of junior nurses in operating theatre, the application of QC techniques, and the ability of their finding and solving problems before and after the launching of QCC activity, we drew a conclusion that the developing of QCC activity improved the professional ability of the young nurses and enhanced the quality of nursing supervision in operating theatre, at the meanwhile, it played a good role in promoting the launching of high quality nursing.通过对比开展品管圈前后，手术室低年资护士参与度、QC手法运用、年轻护士发现问题、解决问题的能力。分析得出品管圈活动的开展提高了手术室年轻护士业务能力，提升了护理质量管理，同时对优质护理开展起到很好的促进作用

Dichloridobis[2-methyl­sulfanyl-4-(pyridin-2-yl)pyrimidine-κ2 N 3,N 4]cobalt(II)

The asymmetric unit of the title compound, [CoCl2(C10H9N3S)2], contains one half-mol­ecule with the CoII atom situtated on a twofold rotational axis. The CoII atom, in an octa­hedral enviroment, is coordinated by four N atoms from two 2-methyl­sulfanyl-4-(pyridin-2-yl)pyrimidine ligands and two Cl atoms

Salt stress-induced FERROCHELATASE 1 improves resistance to salt stress by limiting sodium accumulation in Arabidopsis thaliana

Ferrochelatase-1 as a terminal enzyme of heme biosynthesis regulates many essential metabolic and physiological processes. Whether FC1 is involved in plant response to salt stress has not been described. This study shows that Arabidopsis overexpressing AtFC1 displays resistance to high salinity, whereas a T-DNA insertion knock-down mutant fc1 was more sensitive to salt stress than wild-type plants. AtFC1 conferred plant salt resistance by reducing Na+ concentration, enhancing K+ accumulation and preventing lysis of the cell membrane. Such observations were associated with the upregulation of SOS1, which encodes a plasma membrane Na+/H+ antiporter. AtFC1 overexpression led to a reduced expression of several well known salt stress-responsive genes such as NHX1 and AVP1, suggesting that AtFC1-regulated low concentration of Na+ in plants might not be through the mechanism for Na+ sequestration. To investigate the mechanism leading to the role of AtFC1 in mediating salt stress response in plants, a transcriptome of fc1 mutant plants under salt stress was profiled. Our data show that mutation of AtFC1 led to 490 specific genes up-regulated and 380 specific genes down-regulated in fc1 mutants under salt stress. Some of the genes are involved in salt-induced oxidative stress response, monovalent cation-proton (Na+/H+) exchange, and Na+ detoxification

Quantifying long-term discards from Queensland’s (Australia) east Coast otter trawl fishery

This article estimated the weight of annual discards in the Queensland east coast otter trawl fishery. Discards data were analysed using three generalized linear mixed models to derive adjusted discard rates, expressed as kg per retained catch, kg per boat day, and kg per area swept by trawls, respectively. Model explanatory terms included trawl fishing sector, presence/absence of bycatch reduction devices (BRDs), lunar phase, and whether the data were obtained from commercial vessels during their normal fishing activities or during research charters. Adjusted discard rates were then used to derive three estimates of annual discards and the average used to examine a long-term discard trends from 1988 to 2014. Total discards declined significantly from a peak of approximately 67 000 t in 1997 to approximately 21 000 t from 2011 to 2014, largely due to a decline in fishing effort, and to a lesser degree, the effects of BRDs that were mandated in the fishery in the early 2000s. Copyright Commonwealth of Australia 201

Effect of iguratimod on diclofenac metabolism by CYP2C9 in rats and human recombinant CYP2C9 yeast cells

Iguratimod (IGU, also known as T-614), a novel disease modifying antirheumatic drug intended to cure patients with rheumatoid arthritis (RA). The purpose of this study is to evaluate the effect of IGU on the pharmacokinetics of CYP2C9 probe drug diclofenac and its metabolite 4′-hydroxy diclofenac in vivo and in vitro. In in vivo experiments, 24 rats were randomly assigned to three groups consisting of the control group (Normal saline), low dose IGU group (10 mg/kg) and high dose IGU group (30 mg/ kg). Blood samples were collected from orbital sinuses vein before 1 hour and serial times of giving diclofenac (15 mg/kg) to all the rats. Plasma concentration of diclofenac and its metabolite 4´-hydroxy diclofenac were assayed by high performance liquid chromatography. Pharmacokinetic parameters were assessed by Winnonlin 6.4 pharmacokinetic software. Moreover, in vitro studies were performed in recombinant human CYP2C9 yeast cell system. IGU at low dose showed no significant differences in the pharmacokinetic parameters of diclofenac and 4-hydroxy diclofenac in vivo when compared with control group (p>0.005). However, at the high dose of IGU, the pharmacokinetic parameters of 4´-hydroxy metabolite of diclofenac increase in half-life (T1/2) and mean area under the curve (AUC0→24), while a decrease in mean clearance (CL, mL/h/kg) and volume of distribution Vz (mL/kg). In addition, in in vitro study, high doses of IGU reduces the metabolism rate of diclofenac. IGU at high dose significantly increase the pharmacokinetics parameters of 4´-hydroxy diclofenac in rats. Additionally, it also showed the potent inhibitory effect on diclofenac metabolism in recombinant human CYP2C9 yeast cells