On Technology Transfer to an Asymmetric Cournot Duopoly

This note studies the transfer of a cost-reducing innovation from an independent patent-holder to an asymmetric Cournot duopoly that has different unit costs of production. It is found that royalty licensing can be superior to fixed-fee licensing for the independent patent-holder.Cournot duopoly

Home Appreciation Participation Notes: A Solution to Housing Affordability and the Current Mortgage Crisis

This paper introduces Home Appreciation Participation Notes (HAPNs), an innovative new housing finance tool. Housing is a commodity providing two distinct utilities: shelter and investment. Traditionally, buyers have had to purchase both elements in tandom. HAPNs allow buyers to purchase these elements individually. Thus, buyers can focus on purchasing housing units that best fit their shelter needs, investing in housing appreciation to whatever extent is appropriate for the needs of their investment portfolio. HAPNs are different from previous financing tools in three key ways: there is no payment burden until ownership of the home is transferred, the risk of housing price declines is shifted to investors, and the final payoff is indexed to the appreciation rates of local housing prices. With these three features, HAPNs considerably improve the affordability of homeownership while reducing the risk of default and avoiding the moral hazard associated with shared appreciation instruments.

Deterministic Polynomial-Time Algorithms for Designing Short DNA Words

Designing short DNA words is a problem of constructing a set (i.e., code) of n DNA strings (i.e., words) with the minimum length such that the Hamming distance between each pair of words is at least k and the n words satisfy a set of additional constraints. This problem has applications in, e.g., DNA self-assembly and DNA arrays. Previous works include those that extended results from coding theory to obtain bounds on code and word sizes for biologically motivated constraints and those that applied heuristic local searches, genetic algorithms, and randomized algorithms. In particular, Kao, Sanghi, and Schweller (2009) developed polynomial-time randomized algorithms to construct n DNA words of length within a multiplicative constant of the smallest possible word length (e.g., 9 max{log n, k}) that satisfy various sets of constraints with high probability. In this paper, we give deterministic polynomial-time algorithms to construct DNA words based on derandomization techniques. Our algorithms can construct n DNA words of shorter length (e.g., 2.1 log n + 6.28 k) and satisfy the same sets of constraints as the words constructed by the algorithms of Kao et al. Furthermore, we extend these new algorithms to construct words that satisfy a larger set of constraints for which the algorithms of Kao et al. do not work.Comment: 27 page

Mach number effects on transonic aeroelastic forces and flutter characteristics

Transonic aeroelastic stability analysis and flutter calculations are presented for a generic transport-type wing based on the use of the CAP-TSD (Computational Aeroelasticity Program - Transonic Small Disturbance) finite-difference code. The CAP-TSD code was recently developed for transonic unsteady aerodynamic and aeroelastic analysis of complete aircraft configurations. A binary aeroelastic system consisting of simple bending and torsion modes was used to study aeroelastic behavior at transonic speeds. Generalized aerodynamic forces are presented for a wide range of Mach number and reduced frequency. Aeroelastic characteristics are presented for variations in freestream Mach number, mass ratio, and bending-torsion frequency ratio. Flutter boundaries are presented which have two transonic dips in flutter speed. The first dip is the usual transonic dip involving a bending-dominated flutter mode. The second dip is characterized by a single degree-of-freedom torsion oscillation. These aeroelastic results are physically interpreted and shown to be related to the steady state shock location and changes in generalized aerodynamic forces due to freestream Mach number

Three-dimensional time-marching aeroelastic analyses using an unstructured-grid Euler method

Modifications to a three dimensional, implicit, upwind, unstructured-grid Euler code for aeroelastic analysis of complete aircraft configurations are described. The modifications involve the addition of the structural equations of motion for their simultaneous time integration with the governing flow equations. The paper presents a detailed description of the time marching aeroelastic procedure and presents comparisons with experimental data to provide an assessment of the capability. Flutter results are shown for an isolated 45 degree swept-back wing and a supersonic transport configuration with a fuselage, clipped delta wing, and two identical rearward-mounted nacelles. Comparisons between computed and experimental flutter characteristics show good agreement, giving confidence in the accuracy of the aeroelastic capability that was developed

Short-hairpin RNA library: identification of therapeutic partners for gefitinib-resistant non-small cell lung cancer.

Somatic mutations of the epidermal growth factor receptor often cause resistance to therapy with tyrosine kinase inhibitor in non-small cell lung cancer (NSCLC). In this study, we aimed to identify partner drugs and pathways that can induce cell death in combination with gefitinib in NSCLC cells. We undertook a genome-wide RNAi screen to identify synthetic lethality with gefitinib in tyrosine kinase inhibitor resistant cells. The screening data were utilized in different approaches. Firstly, we identified PRKCSH as a candidate gene, silencing of which induces apoptosis of NSCLC cells treated with gefitinib. Next, in an in silico gene signature pathway analysis of shRNA library data, a strong correlation of genes involved in the CD27 signaling cascade was observed. We showed that the combination of dasatinib (NF-κB pathway inhibitor) with gefitinib synergistically inhibited the growth of NSCLC cells. Lastly, utilizing the Connectivity Map, thioridazine was identified as a top pharmaceutical perturbagen. In our experiments, it synergized with gefitinib to reduce p-Akt levels and to induce apoptosis in NSCLC cells. Taken together, a pooled short-hairpin library screen identified several potential pathways and drugs that can be therapeutic targets for gefitinib resistant NSCLC

Aeroelastic analysis of wings using the Euler equations with a deforming mesh

Modifications to the CFL3D three dimensional unsteady Euler/Navier-Stokes code for the aeroelastic analysis of wings are described. The modifications involve including a deforming mesh capability which can move the mesh to continuously conform to the instantaneous shape of the aeroelastically deforming wing, and including the structural equations of motion for their simultaneous time-integration with the governing flow equations. Calculations were performed using the Euler equations to verify the modifications to the code and as a first step toward aeroelastic analysis using the Navier-Stokes equations. Results are presented for the NACA 0012 airfoil and a 45 deg sweptback wing to demonstrate applications of CFL3D for generalized force computations and aeroelastic analysis. Comparisons are made with published Euler results for the NACA 0012 airfoil and with experimental flutter data for the 45 deg sweptback wing to assess the accuracy of the present capability. These comparisons show good agreement and, thus, the CFL3D code may be used with confidence for aeroelastic analysis of wings