The carbohydrate-insulin model does not explain the impact of varying dietary macronutrients on the body weight and adiposity of mice

Acknowledgments This study was funded by the Chinese Academy of Sciences Strategic Program (XDB13030100), the K.C. Wong Foundation, the 1000 Talents Program, and a Wolfson Merit Award to J.R.S. We thank those in the molecular energetics group in Beijing who contributed to handling the animals and the measurement of their food intake and body weight, including L. Li, B. Li, M. Li, G. Wang, X. Zhang, J. Li, C. Niu, E. Couper, A. Whittington-Davies, and M. Mazidi. Author contributions S.H. was involved in the initial experiment design, conducted experiment one, analyzed the data from experiments one and two, performed the IPA-related analysis, and co-wrote the manuscript. L.W. was involved in the sample collection for experiments one and two and conducted the RNA extractions and the RNA-seq. J.T. was involved in the sample and data collection for experiments one and two. D.Y. and Y.X. performed the initial data collection and glucose measurements for experiment two. Y.W. conducted the insulin measurements and was involved in the initial data collection for experiment two. A.D. was involved in the RNA-seq-related analysis. J.R.S. directed both projects, conceived and designed the experiments, contributed to the data analysis, and co-wrote the paper. All of the authors approved the final version prior to submission for publication.Peer reviewedPublisher PD

Maternal High Fat Diet in Lactation Impacts Hypothalamic Neurogenesis and Neurotrophic Development, Leading to Later Life Susceptibility to Obesity in Male but Not Female Mice

Research Funding National Key Research and Development Program of China. Grant Number: 2018YFA0801000 National Natural Science Foundation of China. Grant Number: 92057206 A Wolfson merit professorship from UK Royal Society Postdoctoral Research Foundation of China. Grant Numbers: 2013M540157, 2014T70135 The KC Wong Education Foundation Grants from the "1000 talents" recruitment program A PIFI professional fellowship from CASPeer reviewedPublisher PD

Increased Variation in Body Weight and Food Intake Is Related to Increased Dietary Fat but Not Increased Carbohydrate or Protein in Mice

Funding This study was funded by the National Key R&D Program of China (2019YFA0801900) to JS and the Postdoctoral Innovation Fund (2021) to YW. The original diet exposure experiment was funded by the Chinese Academy of Sciences Strategic Program (XDB13030100). JS was also supported during this work by a PIFI professorial fellowship from CAS and a Wolfson merit award from the UK Royal Society. CORRECTION article Front. Nutr., 21 October 2022 Sec. Nutrition and Metabolism https://doi.org/10.3389/fnut.2022.1049766 Corrigendum: Increased variation in body weight and food intake is related to increased dietary fat but not increased carbohydrate or protein in micePeer reviewedPublisher PD

Effects of dietary macronutrients and body composition on glucose homeostasis in mice

Funding This work was supported by the Chinese Academy of Sciences Strategic Programs (XDA12030209 and XDB13030100), the 1000 Talents Program and a Wolfson Merit Award to J.R.SPeer reviewedPublisher PD

The hedonic overdrive model best explains high-fat diet-induced obesity in C57BL/6 mice

Open Access via the Wiley Agreement National Key R&D Program of China. Grant Number: 2019YFA0801900 Chinese Academy of Sciences. Grant Number: XDB13030100 National Science Foundation of China. Grant Number: 92057206Peer reviewe

Effects of dietary macronutrients on the hepatic transcriptome and serum metabolome in mice

ACKNOWLEDGMENTS The study was funded by National Key R&D Program of China (2019YFA0801900), National Postdoctoral Program for Innovative Talents (BX2021357), Postdoctoral Science Foundation (2021M693393) the Chinese Academy of Sciences Strategic Program (XDB13030100), the National Natural Science Foundation of China (91649108), a PIFI professorial fellowship from CAS and a Wolfson merit award from the UK Royal Society (all to J.R.S unless stated).Peer reviewedPublisher PD

High dietary protein and fat contents exacerbate hepatic senescence and SASP in mice

Dietary choices have a profound impact on the aging process. In addition to the total amount of energy intake, macronutrient composition influences both health and lifespan. However, the exact mechanisms by which dietary macronutrients influence onset and progression of age-associated features remain poorly understood. Cellular senescence is a state of stable growth arrest characterized by the secretion of numerous bioactive molecules with pro-inflammatory properties. Accumulation of senescent cells is considered one of the basic mechanisms of aging and an important contributor to chronic inflammation and tissue degeneration. Whether dietary macronutrients affect the accumulation and the phenotype of senescent cells with age is still unknown. Here, we show that feeding on diets with varying ratios of dietary macronutrients for 3 months has a significant effect on different senescence-associated markers in the mouse liver. High protein intake is associated with higher expression levels of the two classical senescence-associated growth arrest genes, p21 and p16. Furthermore, the expression of many pro-inflammatory secretory markers was increased in diets enriched in protein and further enhanced by increases in fat content. These results provide preliminary evidence that dietary macronutrients have a significant influence on senescence markers and merit further investigation

Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice

Full details of methods and materials are provided in the supplementary materials and the project has been registered at the Open Science Framework (https://doi.org/10.17605/OSF.IO/YH9GZ). The study was funded by the Chinese Academy of Sciences Strategic Program (XDB13030100), the 1000 Talents program, and a Wolfson merit award to J.R.S., and by the National Natural Science Foundation of China (31570409) and funds from Guangdong Academy of Sciences (2017GDASCX-0107) to Q.L.Peer reviewedPostprin