1,099 research outputs found
Temperature dependence of infrared reflectance spectra of InN
To investigate both the optical and electrical properties of InN, we have measured the infrared reflectance spectra of InN thin
films and performed the fitting analyses of the infrared spectra to obtain not only phonon frequencies and the damping factors
but also the carrier concentration of InN. In this paper, we extend the aim of those analyses to the electron mobility and
demonstrate that the temperature dependence of the electron mobility can be discussed using the infrared reflectance spectra
analyses
A Specific class of interneuron mediates inhibitory plasticity in the lateral amygdala
The lateral amygdala (LA) plays a key role in emotional learning and is the main site for sensory input into the amygdala. Within the LA, pyramidal neurons comprise the major cell population with plasticity of inputs to these neurons thought to underlie fear learning. Pyramidal neuron activity is tightly controlled by local interneurons, and GABAergic modulation strongly influences amygdala-dependent learning. Synaptic inputs to some interneurons in the LA can also undergo synaptic plasticity, but the identity of these cells and the mechanisms that underlie this plasticity are not known. Here we show that long-term potentiation (LTP) in LA interneurons is restricted to a specific type of interneuron that is defined by the lack of expression of synaptic NR2B subunits. We find that LTP is only present at cortical inputs to these cells and is initiated by calcium influx via calcium-permeable AMPA receptors. LTP is maintained by trafficking of GluR2-lacking AMPA receptors that require an interaction with SAP97 and the actin cytoskeleton. Our results define a novel population of interneurons in the LA that control principal neuron excitability by feed-forward inhibition of cortical origin. This selective enhanced inhibition may contribute to reducing the activity of principal neurons engaged during extinction of conditioned fear
Disability Prevention Programs for Older People: Factors Associated with Medical and Nursing Care Costs
This study aimed to clarify factors associated with medical and nursing care costs for older people living in community and to suggest an effective disability prevention programs. Total of participants in this study was 83 individuals (29 men and 54 women; mean age 81.2 ± 6.3 years old) on November 1st – December 28th, 2014. This study compared the average medical and nursing care costs per month with national average for those aged ≥ 65 years old. Logistic regression test was conducted to examine its association with medical and nursing care costs. Those who had outing activities ≥ 3 times a week were approximately three times less likely to reduce medical and nursing care costs than those who had outing activities < 3 times a week despite three controlled covariates (OR = 3.23 and 95% CI = 1.03 – 10.42). Disability prevention programs that improve frequency of outing at least three times in a week may become a valid economic approach to older people who do not live in nursing home
Illustrating a new global-scale approach to estimating potential reduction in fish species richness due to flow alteration
Changes in river discharge due to human activities and climate change would
affect the sustainability of freshwater ecosystems. To globally assess how
changes in river discharge will affect the future status of freshwater
ecosystems, global-scale hydrological simulations need to be connected with
a model to estimate the durability of freshwater ecosystems. However, the
development of this specific modelling combination for the global scale is
still in its infancy. In this study, two statistical methods are introduced
to link flow regimes to fish species richness (FSR): one is based on a
linear relationship between FSR and mean river discharge (hereafter, FSR-MAD
method), and the other is based on a multi-linear relationship between FSR
and ecologically relevant flow indices involving several other flow
characteristics and mean river discharge (FSR-FLVAR method). The FSR-MAD
method has been used previously in global simulation studies. The FSR-FLVAR
method is newly introduced here. These statistical methods for estimating
FSR were combined with a set of global river discharge simulations to
evaluate the potential impact of climate-change-induced flow alterations on
FSR changes. Generally, future reductions in FSR with the FSR-FLVAR method
are greater and much more scattered than with the FSR-MAD method. In arid
regions, both methods indicate reductions in FSR because mean discharge is
projected to decrease from past to future, although the magnitude of
reductions in FSR is different between the two methods. In contrast, in
heavy-snow regions a large reduction in FSR is shown by the FSR-FLVAR method
due to increases in the frequency of low and high flows. Although further
research is clearly needed to conclude which method is more appropriate,
this study demonstrates that the FSR-FLVAR method could produce considerably
different results when assessing the global role of flow alterations in
changing freshwater ecosystems
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Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome
Dravet syndrome is a severe epileptic encephalopathy mainly caused by heterozygous mutations in the SCN1A gene encoding a voltage-gated sodium channel Nav1.1. We previously reported dense localization of Nav1.1 in parvalbumin (PV)-positive inhibitory interneurons in mice and abnormal firing of those neurons in Nav1.1-deficient mice. In the present study, we investigated the physiologic consequence of selective Nav1.1 deletion in mouse global inhibitory neurons, forebrain excitatory neurons or PV cells, using vesicular GABA transporter (VGAT)-Cre, empty spiracles homolog 1 (Emx1)-Cre or PV-Cre recombinase drivers. We show that selective Nav1.1 deletion using VGAT-Cre causes epileptic seizures and premature death that are unexpectedly more severe than those observed in constitutive Nav1.1-deficient mice. Nav1.1 deletion using Emx1-Cre does not cause any noticeable abnormalities in mice; however, the severe lethality observed with VGAT-Cre-driven Nav1.1 deletion is rescued by additional Nav1.1 deletion using Emx1-Cre. In addition to predominant expression in PV interneurons, we detected Nav1.1 in subpopulations of excitatory neurons, including entorhino-hippocampal projection neurons, a subpopulation of neocortical layer V excitatory neurons, and thalamo-cortical projection neurons. We further show that even minimal selective Nav1.1 deletion, using PV-Cre, is sufficient to cause spontaneous epileptic seizures and ataxia in mice. Overall, our results indicate that functional impairment of PV inhibitory neurons with Nav1.1 haploinsufficiency contributes to the epileptic pathology of Dravet syndrome, and show for the first time that Nav1.1 haploinsufficiency in excitatory neurons has an ameliorating effect on the pathology
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