A Virtual Reconstruction Methodology for Archaeological Heritage in East Asia – Practical Experience from the Re-relic Program in China

[EN] There is as much abundance of archaeological heritage in East Asia as there is diversity in the methodology for its reconstruction and representation. The Re-relic program in China recognizes the uniqueness of archaeological heritage in East Asia and has developed a tailored virtual reconstruction methodology that is both scientifically robust and popular for public interpretation. The theoretical consideration and field experience over the years shall contribute to the global understanding of the value and technique in virtual reconstruction, while testifying to the very principles of Seville Charter.[ES] El este de Asia se caracteriza tanto por su abundancia en patrimonio arqueológico como por su diversidad metodológica a la hora de llevar a cabo reconstrucciones y representaciones de dicho patrimonio. El programa Re-reliquia en China reconoce la singularidad del patrimonio arqueológico en el este de Asia y ha desarrollado una metodología adaptada para la reconstrucción virtual, científicamente sólida para la interpretación pública. El examen teórico y la experiencia de campo en los próximos años contribuirán a la comprensión global del valor y la técnica en la reconstrucción virtual, al prestar atención a los principios de la Carta de Sevilla.He, Y.; Gao, M.; Shang, J. (2013). A Virtual Reconstruction Methodology for Archaeological Heritage in East Asia – Practical Experience from the Re-relic Program in China. Virtual Archaeology Review. 4(9):93-99. https://doi.org/10.4995/var.2013.4253OJS939949GUO DAIHENG et al. (2002): Chinese Architecture, Yale University Press.HE, Yan (2011): "Re-relic/Yuanminguan: An Effective Practice in Virtual Restoration and Visual Representaion of Cultural Heritage", in CIPA symposium proceedings 2011.LIANG SSU CHENG, (1984): Chinese Architecture, A Pictorial History, MIT Press, Cambridge, Massachusetts.LOPEZ-MENCHERO, V.M. et al. (2011): "The Principles of the Seville Charter", in CIPA symposium proceedings 2011

2-(Hydrazonomethyl)phenol

The conformation of the title compound, C7H8N2O, is stabilized by an intra­molecular O—H⋯N hydrogen bond. The crystal structure shows inter­molecular N—H⋯O hydrogen bonds

Shape-Free Finite Element Method: Another Way between Mesh and Mesh-Free Methods

Performances of the conventional finite elements are closely related to the mesh quality. Once distorted elements are used, the accuracy of the numerical results may be very poor, or even the calculations have to stop due to various numerical problems. Recently, the author and his colleagues developed two kinds of finite element methods, named hybrid stress-function (HSF) and improved unsymmetric methods, respectively. The resulting plane element models possess excellent precision in both regular and severely distorted meshes and even perform very well under the situations in which other elements cannot work. So, they are called shape-free finite elements since their performances are independent to element shapes. These methods may open new ways for developing novel high-performance finite elements. Here, the thoughts, theories, and formulae of above shape-free finite element methods were introduced, and the possibilities and difficulties for further developments were also discussed

Recent progress and debates in molecular physiology of Na+ uptake in teleosts

How teleosts take up Na+ from the surrounding freshwater (FW) as well as the underlying mechanisms associated with this process have received considerable attention over the past 85 years. Owing to an enormous ion gradient between hypotonic FW and fish body fluids, teleosts gills have to actively absorb Na+ (via ionocytes) to compensate for the passive loss of Na+. To date, three models have been proposed for Na+ uptake in teleost ionocytes, including Na+/H+ exchanger (NHE)-mediated, acid-sensing ion channel (ASIC)-mediated, Na+-Cl- co-transporter (NCC)-mediated pathways. However, some debates regarding these models and unclear mechanisms still remain. To better understand how teleosts take up Na+ from FW, this mini-review summarizes the main progress and related regulatory mechanisms of Na+ uptake, and discusses some of the challenges to the current models

Orphan Nuclear Receptor Nur77 Inhibits Cardiac Hypertrophic Response to Beta-Adrenergic Stimulation.

The orphan nuclear receptor Nur77 plays critical roles in cardiovascular diseases, and its expression is markedly induced in the heart after beta-adrenergic receptor (β-AR) activation. However, the functional significance of Nur77 in β-AR signaling in the heart remains unclear. By using Northern blot, Western blot, and immunofluorescent staining assays, we showed that Nur77 expression was markedly upregulated in cardiomyocytes in response to multiple hypertrophic stimuli, including isoproterenol (ISO), phenylephrine (PE), and endothelin-1 (ET-1). In a time- and dose-dependent manner, ISO increases Nur77 expression in the nuclei of cardiomyocytes. Overexpression of Nur77 markedly inhibited ISO-induced cardiac hypertrophy by inducing nuclear translocation of Nur77 in cardiomyocytes. Furthermore, cardiac overexpression of Nur77 by intramyocardial injection of Ad-Nur77 substantially inhibited cardiac hypertrophy and ameliorated cardiac dysfunction after chronic infusion of ISO in mice. Mechanistically, we demonstrated that Nur77 functionally interacts with NFATc3 and GATA4 and inhibits their transcriptional activities, which are critical for the development of cardiac hypertrophy. These results demonstrate for the first time that Nur77 is a novel negative regulator for the β-AR-induced cardiac hypertrophy through inhibiting the NFATc3 and GATA4 transcriptional pathways. Targeting Nur77 may represent a potentially novel therapeutic strategy for preventing cardiac hypertrophy and heart failure

Clinical analysis of 1 case of solitary brain metastases misdiagnosed as cerebral infarction

目的  通过报告1例误诊为脑梗死的单发性脑转移瘤患者的诊断过程，总结单发性脑转移瘤的临床、影像学特征及诊断治疗方法。方法  回顾性分析1例单发性脑转移瘤患者的诊断过程，并复习有关文献。结果  脑转移瘤常多发，单发者仅占25%，发病年龄以40～60岁多见，原发病灶以肺最常见。脑转移瘤常位于脑叶灰白质交界处，不同部位的肿瘤可出现不同的临床表现，影像学上常表现为“小病灶、大水肿”，与颅内原发肿瘤不易区分，头颅CT或 MRI增强检查并查到其他部位的原发肿瘤病灶后可确定诊断。目前主张单发性脑转移瘤应进行手术切除，术后辅以立体定向放射治疗和全脑放射治疗。结论  15%的脑转移瘤患者既往无肿瘤病史，因此诊断脑瘤后须在身体其他部位查找有无原发病灶，避免误诊、漏诊。对于中老年肺癌或其他恶性肿瘤患者，无论有无中枢神经系统症状，均应积极进行头颅CT甚至MRI检查，以发现较小的早期脑转移瘤病灶。对于易患肺癌人群，应该每年体检，进行胸部X线检查或低剂量CT筛查，以便早期发现肺癌病灶，早期治疗，防止肿瘤转移。Objective: To report 1 case was misdiagnosed as cerebral infarction solitary brain metastases (SBM) in patients with diagnosis process, and to summarize the clinical and imaging features of the SBM and its treatment. Methods: To retrospectively analyze the diagnostic process of 1 case of SBM patients, and to have literature review. Results: Patients with solitary and multiple brain metastases accounted for only 25%, the onset age was 40 ~ 60 years old, and the most common primary lesion is in lung. Brain metastases are often on the border, in between lobes grey matter. Different parts of the tumors can present different clinical manifestations. The diagnostic imaging is often shown as "small lesions, large edema", and intracranial primary tumor is not easy to distinguish, Head CT or MRI examination of tumors in other parts could confirm the diagnosis. Now that SBM should undergo surgery resection, postoperative supplemented by stereotactic radiotherapy and whole brain radiotherapy. Conclusions: 15% of the patients with brain metastases haven’t got previous medical history, the doctor is therefore must look for presence of primary lesions in other parts of the body for accurate diagnosis, to avoid the misdiagnosis and missed diagnosis. Middle-aged and elderly patients with lung cancer or other malignant tumor, regardless of the presence of the central nervous system symptoms, should carry on the head CT or MRI examination, and find smaller early brain metastatic lesions. People who are susceptible to lung cancer should have annual physical examination, chest X-ray or low dose CT screening for early detection of lung cancer lesions, early treatment and prevention of tumor metastasi

ACT001 improved cardiovascular function in septic mice by inhibiting the production of proinflammatory cytokines and the expression of JAK-STAT signaling pathway

Sepsis is a life-threatening multiple organ dysfunction syndrome (MODS) caused by a microbial infection that leads to high morbidity and mortality worldwide. Sepsis-induced cardiomyopathy (SIC) and coagulopathy promote the progression of adverse outcomes in sepsis. Here, we reported that ACT001, a modified compound of parthenolide, improved the survival of sepsis mice. In this work, we used cecal ligation and puncture (CLP) model to induce SIC. Transthoracic echocardiography and HE staining assays were adopted to evaluate the influence of ACT001 on sepsis-induced cardiac dysfunction. Our results showed that ACT001 significantly improved heart function and reduced SIC. Coagulation accelerates organ damage in sepsis. We found that ACT001 decreased blood clotting in the FeCl3-induced carotid artery thrombosis experiment. ACT001 also reduced the production of neutrophil extracellular traps (NETs). RNA-sequencing of heart tissues revealed that ACT001 significantly downregulated the expression of pro-inflammatory cytokines and the JAK-STAT signaling pathway. These results were confirmed with real-time PCR and ELISA. In summary, we found ACT001 rescued mice from septic shock by protecting the cardiovascular system. This was partially mediated by inhibiting pro-inflammatory cytokine production and down-regulating the JAK-STAT signaling

Comparison of Double Kissing Crush Versus Culotte Stenting for Unprotected Distal Left Main Bifurcation Lesions Results From a Multicenter, Randomized, Prospective DKCRUSH-III Study

ObjectivesThe study aimed to investigate the difference in major adverse cardiac event (MACE) at 1-year after double kissing (DK) crush versus Culotte stenting for unprotected left main coronary artery (UPLMCA) distal bifurcation lesions.BackgroundDK crush and Culotte stenting were reported to be effective for treatment of coronary bifurcation lesions. However, their comparative performance in UPLMCA bifurcation lesions is not known.MethodsA total of 419 patients with UPLMCA bifurcation lesions were randomly assigned to DK (n = 210) or Culotte (n = 209) treatment. The primary endpoint was the occurrence of a MACE at 1 year, including cardiac death, myocardial infarction, and target vessel revascularization (TVR). In-stent restenosis (ISR) at 8 months was secondary endpoint, and stent thrombosis (ST) served as a safety endpoint. Patients were stratified by SYNTAX (Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery) and NERS (New Risk Stratification) scores.ResultsPatients in the Culotte group had significant higher 1-year MACE rate (16.3%), mainly driven by increased TVR (11.0%), compared with the DK group (6.2% and 4.3%, respectively; all p < 0.05). ISR rate in side branch was 12.6% in the Culotte group and 6.8% in the DK group (p = 0.037). Definite ST rate was 1.0% in the Culotte group and 0% in the DK group (p = 0.248). Among patients with bifurcation angle ≥70°, NERS score ≥20, and SYNTAX score ≥23, the 1-year MACE rate in the DK group (3.8%, 9.2%, and 7.1%, respectively) was significantly different to those in the Culotte group(16.5%, 20.4%, and 18.9%, respectively; all p < 0.05).ConclusionsCulotte stenting for UPLMCA bifurcation lesions was associated with significantly increased MACEs, mainly due to the increased TVR. (Double Kissing [DK] Crush Versus Culotte Stenting for the Treatment of Unprotected Distal Left Main Bifurcation Lesions: DKCRUSH-III, a Multicenter Randomized Study Comparing Double-Stent Techniques; ChiCTR-TRC-00000151