Effective Audio Classification Network Based on Paired Inverse Pyramid Structure and Dense MLP Block

Recently, massive architectures based on Convolutional Neural Network (CNN) and self-attention mechanisms have become necessary for audio classification. While these techniques are state-of-the-art, these works' effectiveness can only be guaranteed with huge computational costs and parameters, large amounts of data augmentation, transfer from large datasets and some other tricks. By utilizing the lightweight nature of audio, we propose an efficient network structure called Paired Inverse Pyramid Structure (PIP) and a network called Paired Inverse Pyramid Structure MLP Network (PIPMN). The PIPMN reaches 96\% of Environmental Sound Classification (ESC) accuracy on the UrbanSound8K dataset and 93.2\% of Music Genre Classification (MGC) on the GTAZN dataset, with only 1 million parameters. Both of the results are achieved without data augmentation or model transfer. Public code is available at: https://github.com/JNAIC/PIPM

Modeling Hα\alpha and He 10830 transmission spectrum of WASP-52b

Escaping atmosphere has been detected by the excess absorption of Ly$\alpha$, H$\alpha$ and He triplet (10830$\rm\AA$) lines. Simultaneously modeling the absorption of the H$\alpha$ and He 10830 lines can provide useful constraints about the exoplanetary atmosphere. In this paper, we use a hydrodynamic model combined with a non-local thermodynamic model and a new Monte Carlo simulation model to obtain the H(2) and He(2$^3$S) populations. The Monte Carlo simulations of Ly$\alpha$ radiative transfer are performed with assumptions of a spherical stellar Ly$\alpha$ radiation and a spherical planetary atmosphere, for the first time, to calculate the Ly$\alpha$ mean intensity distribution inside the planetary atmosphere, necessary in estimating the H(2) population. We model the transmission spectra of the H$\alpha$ and He 10830 lines simultaneously in hot Jupiter WASP-52b. We find that models with many different H/He ratios can reproduce the H$\alpha$ observations well if the host star has (1) a high X-ray/extreme ultraviolet (XUV) flux ($F_{\rm XUV}$) and a relatively low X-ray fraction in XUV radiation ($\beta_m$), or (2) a low $F_{\rm XUV}$ and a high $\beta_m$. The simulations of He 10830 $\rm\AA$ triplet suggest that a high H/He ratio ($\sim$ 98/2) is required to fit the observation. The models that fit both lines well confine $F_{\rm XUV}$ to be about 0.5 times the fiducial value and $\beta_m$ to have a value around 0.3. The models also suggest that hydrogen and helium originate from the escaping atmosphere, and the mass-loss rate is about 2.8$\times 10^{11}$ g s$^{-1}$.Comment: Accepted for publication in ApJ, 48 page

Multimodal ChatGPT for Medical Applications: an Experimental Study of GPT-4V

In this paper, we critically evaluate the capabilities of the state-of-the-art multimodal large language model, i.e., GPT-4 with Vision (GPT-4V), on Visual Question Answering (VQA) task. Our experiments thoroughly assess GPT-4V's proficiency in answering questions paired with images using both pathology and radiology datasets from 11 modalities (e.g. Microscopy, Dermoscopy, X-ray, CT, etc.) and fifteen objects of interests (brain, liver, lung, etc.). Our datasets encompass a comprehensive range of medical inquiries, including sixteen distinct question types. Throughout our evaluations, we devised textual prompts for GPT-4V, directing it to synergize visual and textual information. The experiments with accuracy score conclude that the current version of GPT-4V is not recommended for real-world diagnostics due to its unreliable and suboptimal accuracy in responding to diagnostic medical questions. In addition, we delineate seven unique facets of GPT-4V's behavior in medical VQA, highlighting its constraints within this complex arena. The complete details of our evaluation cases are accessible at https://github.com/ZhilingYan/GPT4V-Medical-Report

Evidence for association between Disrupted-in-schizophrenia 1 (DISC1) gene polymorphisms and autism in Chinese Han population: a family-based association study

<p>Abstract</p> <p>Background</p> <p>Disrupted-in-Schizophrenia 1 (<it>DISC1</it>) gene is one of the most promising candidate genes for major mental disorders. In a previous study, a Finnish group demonstrated that <it>DISC1 </it>polymorphisms were associated with autism and Asperger syndrome. However, the results were not replicated in Korean population. To determine whether <it>DISC1 </it>is associated with autism in Chinese Han population, we performed a family-based association study between <it>DISC1 </it>polymorphisms and autism.</p> <p>Methods</p> <p>We genotyped seven tag single nucleotide polymorphisms (SNPs) in <it>DISC1</it>, spanning 338 kb, in 367 autism trios (singleton and their biological parents) including 1,101 individuals. Single SNP association and haplotype association analysis were performed using the family-based association test (FBAT) and Haploview software.</p> <p>Results</p> <p>We found three SNPs showed significant associations with autism (rs4366301: G > C, Z = 2.872, <it>p </it>= 0.004; rs11585959: T > C, Z = 2.199, <it>p </it>= 0.028; rs6668845: A > G, Z = 2.326, <it>p </it>= 0.02). After the Bonferroni correction, SNP rs4366301, which located in the first intron of <it>DISC1</it>, remained significant. When haplotype were constructed with two-markers, three haplotypes displayed significant association with autism. These results were still significant after using the permutation method to obtain empirical <it>p </it>values.</p> <p>Conclusions</p> <p>Our study provided evidence that the <it>DISC1 </it>may be the susceptibility gene of autism. It suggested <it>DISC1 </it>might play a role in the pathogenesis of autism.</p

The dynamical stability of W Ursae Majoris-type systems

Theoretical study indicates that a contact binary system would merge into a rapidly rotating single star due to tidal instability when the spin angular momentum of the system is more than a third of its orbital angular momentum. Assuming that W UMa contact binary systems rigorously comply with the Roche geometry and the dynamical stability limit is at a contact degree of about 70%, we obtain that W UMa systems might suffer Darwin's instability when their mass ratios are in a region of about 0.076--0.078 and merge into the fast-rotating stars. This suggests that the W UMa systems with mass ratio $q\leq0.076$ can not be observed. Meanwhile, we find that the observed W UMa systems with a mass ratio of about 0.077, corresponding to a contact degree of about 86% would suffer tidal instability and merge into the single fast-rotating stars. This suggests that the dynamical stability limit for the observed W UMa systems is higher than the theoretical value, implying that the observed systems have probably suffered the loss of angular momentum due to gravitational wave radiation (GR) or magnetic stellar wind (MSW).Comment: 4 pages, 3 figures, published in MNRAS (2006MNRAS.369.2001

The Effect of Organic-cr Dietary Supplementation on Stress Response in Transport-stressed Beef Cattle

Transportation over long distances resulted in stress at animal. Under these circumstances, animalusually manifest depression and the impact on physiological condition changes and loss of body weight.The objectives of the research were to examine effect supplementation of organic-Cr type into diets intransport-stress beef cattle on physiological condition, haematochemical (included were haematologicalcondition and blood chemical) and body weight changes. The experiment was conducted using 16 beefcattle those were transported by truck for a distance of 400 km from Malangbong to Tangerang. Theexperiment was arranged by Completely Randomized Design with four treatments and four replications.The dietary treatments consisted of R0 (basal diet without Cr supplemented), R1 (R0+3ppm organic-Crresulted of alkali hydrolysis), R2 (R0+3 ppm organic-Cr resulted from bioprocess), R3 (R0+3 ppmorganic-Cr resulted from bioremediation). The result indicated that type of organic-Cr supplementationat 3 ppm in diet did not influence physiological condition, haematochemical and body weight at beefcattle transported for seven hours. There was indication that beef cattle fed on control diet (without Cr)showed a stress symptom, their loss of body weight were higher (5.41%) compared to beef given dietcontains organic-Cr (3.72%, 5.04% and 4.83%, respectively for R1, R2 and R3)

A Major and Stable QTL for Bacterial Wilt Resistance on Chromosome B02 Identified Using a High-Density SNP-Based Genetic Linkage Map in Cultivated Peanut Yuanza 9102 Derived Population

Bacterial wilt (BW) is one of the important diseases limiting the production of peanut (Arachis hypogaea L.) worldwide. The sufficient precise information on the quantitative trait loci (QTL) for BW resistance is essential for facilitating gene mining and applying in molecular breeding. Cultivar Yuanza 9102 is BW resistant, bred from wide cross between cultivated peanut Baisha 1016 and a wild diploid peanut species A. chacoense with BW resistance. In this study, we aim to map the major QTLs related to BW-resistance in Yuanza 9102. A high density SNP-based genetic linkage map was constructed through double-digest restriction-site-associated DNA sequencing (ddRADseq) technique based on Yuanza 9102 derived recombinant inbred lines (RILs) population. The map contained 2,187 SNP markers distributed on 20 linkage groups (LGs) spanning 1566.10 cM, and showed good synteny with AA genome from A. duranensis and BB genome from A. ipaensis. Phenotypic frequencies of BW resistance among RIL population showed two-peak distribution in four environments. Four QTLs explaining 5.49 to 23.22% phenotypic variance were identified to be all located on chromosome B02. The major QTL, qBWB02.1 (12.17–23.33% phenotypic variation explained), was detected in three environments showing consistent and stable expression. Furthermore, there was positive additive effect among these major and minor QTLs. The major QTL region was mapped to a region covering 2.3 Mb of the pseudomolecule B02 of A. ipaensis which resides in 21 nucleotide-binding site -leucine-rich repeat (NBS-LRR) encoding genes. The result of the major stable QTL (qBWB02.1) not only offers good foundation for discovery of BW resistant gene but also provide opportunity for deployment of the QTL in marker-assisted breeding in peanut

Case Report: A Novel COL1A1 Missense Mutation Associated With Dentineogenesis Imperfecta Type I

Background: Osteogenesis imperfecta (OI) is a clinical and genetic disorder that results in bone fragility, blue sclerae and dentineogenesis imperfecta (DGI), which is mainly caused by a mutation in the COL1A1 or COL1A2 genes, which encode type I procollagen.Case Report: A missense mutation (c.1463G &gt; C) in exon 22 of the COL1A1 gene was found using whole-exome sequencing. However, the cases reported herein only exhibited a clinical DGI-I phenotype. There were no cases of bone disease or any other common abnormal symptom caused by a COL1A1 mutation. In addition, the ultrastructural analysis of the tooth affected with non-syndromic DGI-I showed that the abnormal dentine was accompanied by the disruption of odontoblast polarization, a reduced number of odontoblasts, a reduction in hardness and elasticity, and the loss of dentinal tubules, suggesting a severe developmental disorder. We also investigated the odontoblast differentiation ability using dental pulp stem cells (DPSCs) that were isolated from a patient with DGI-I and cultured. Stem cells isolated from patients with DGI-I are important to elucidate their pathogenesis and underlying mechanisms to develop regenerative therapies.Conclusion: This study can provide new insights into the phenotype-genotype association in collagen-associated diseases and improve the clinical diagnosis of OI/DGI-I