Histone Shock and The Relation between Histone and Plasmin

The relation between protease and nucleoprotein (histone) is described on the point of anaphylactoid shock in guinea pigs. Histone caused the anaphylactoid shock in guinea pigs, but histone with plasmin incubated for twenty-four hours did not. Histone released the histamine significantly from the mast cells

Histamine Release from Isolated Rat Mast Cells by Adding Plasmin

The histamine release from isolated rat mast cells was accomplished by adding antigen, histamine liberators , and proteasse. The percentage of histamine release from the cells after adding the above mentioned agents is as follows : antigen, 41.5%; 48/80, 65.9; tween 20, 28.9; plasmin, 37.2; heated plasmin, 19.5; and trypsin, 42.8