High expression of a novel carnitine palmitoyltransferase I like protein in rat brown adipose tissue and heart: isolation and characterization of its cDNA clone

AbstractTo characterize energy metabolism in rat brown adipose tissue (BAT), we carried out differential screening of a cDNA library of BAT with a cDNA probe of white adipose tissue (WAT) and isolated one cDNA clone. It contained a single open reading frame of 2,316 bases which encodes a protein of 88.2 kDa. The predicted amino acid sequence showed the highest homology (62.6%) with that of rat carnitine palmitoyltransferase I (CPTI). The transcript corresponding to this cDNA was found to be abundantly expressed in BAT and heart. Therefore, the isolated clone is concluded to encode a CPTI like protein expressed in BAT and heart

A New Gamma-Ray Source in the Vicinity of the Galactic Supernova Remnant G306.3−-0.9

A new extended gamma-ray source, which was named as Source A, in the southwest of Galactic supernova remnant (SNR) G306.3$-$0.9 was detected with a significance of $\sim$13$\sigma$ at the location of R.A. (J2000) = 13$^{\rm{h}}$ 17$^{\rm{m}}$ 52$^{\rm{s}\!\!}$.80, Decl. (J2000) = $-$63$^{\circ}$ 55$'$ 48$"\!\!$.00 using about 9 years of Fermi-LAT data. In order to investigate this unidentified gamma-ray source in multi-wavelengths, we performed Swift observations of Source A. In this presentation we summarize the published gamma-ray results, report about the recent ToO Swift observations of Source A, and show our preliminary results of the gamma-ray analysis that we conducted using the new X-ray data.Comment: Published in proceedings of "7th Fermi Symposium 2017", PoS(IFS2017)10

Discovery of recombining plasma inside the extended gamma-ray supernova remnant HB9

We present the results from the Suzaku X-ray Imaging Spectrometer observation of the mixed-morphology supernova remnant (SNR) HB9 (G160.9+2.6). We discovered recombining plasma (RP) in the western Suzaku observation region and the spectra here are well described by a model having collisional ionization equilibrium (CIE) and RP components. On the other hand, the X-ray spectra from the eastern Suzaku observation region are best reproduced by the CIE and non-equilibrium ionization model. We discuss possible scenarios to explain the origin of the RP emission based on the observational properties and concluded that the rarefaction scenario is a possible explanation for the existence of RP. In addition, the gamma-ray emission morphology and spectrum within the energy range of 0.2$-$300 GeV are investigated using $\sim$10 years of data from the Fermi Large Area Telescope (LAT). The gamma-ray morphology of HB9 is best described by the spatial template of radio continuum emission. The spectrum is well-fit to a log-parabola function and its detection significance was found to be $\sim$25$\sigma$. Moreover, a new gamma-ray point source located just outside the south-east region of the SNR's shell was detected with a significance of $\sim$6$\sigma$. We also investigated the archival HI and CO data and detected an expanding shell structure in the velocity range of $-10.5$ and $+1.8$ km s$^{-1}$ that is coinciding with a region of gamma-ray enhancement at the southern rim of the HB9 shell.Comment: 12 pages, 7 figures, accepted for publication in MNRA

Massive trapezial metastasis from gastric adenocarcinoma resected and reconstructed with a vascularized scapular bone graft: A case report

Rationale: Isolated metastasis to the hand bones is very rare. Only seven cases of metastasis to the trapezium have been reported. To the best of our knowledge, this is the first report of a single metastasis to the trapezium from a gastric adenocarcinoma. Patient concerns: A 62-year-old man presented with pain and massive swelling in the right carpometacarpal joint of the thumb. Diagnoses: The patient was diagnosed with trapezial metastasis of advanced gastric adenocarcinoma. Interventions: The patient underwent systemic chemotherapy with cisplatin and S-1, radiotherapy to the metastatic bone, and treatment with denosumab. One year later, the huge metastatic tumor was resected, and the hand was reconstructed using vascularized scapular bone. Outcomes: Eighteen months postoperatively, the patient was satisfied with the appearance of the reconstructed hand and was able to use his right thumb in activities of daily living. Lessons: Although rare, metastasis to the trapezium should be considered in patients with persistent and progressive thumb CMC joint pain.ArticleMedicine 96(50) : e9294(2017)journal articl

A Preliminary Examination of Effect of Massage and Aroma Oil Massage in Foot Care Nursing

AbstractFoot care nursing is attracting attention as a medically effective treatment for the foot lesions caused by such problems as diabetes or aging. In this study, we experimentally examined how aromatherapy affects human brain functions during foot care nursing using near-infrared spectroscopy (NIRS). 11 subjects received both foot care nursing massages and aroma oil massages. We analyzed the changes in their oxygenated hemoglobin (oxy-Hb) concentrations based on their brain activity by t-tests, and the t-test results showed significant differences between two kinds of massages in both the somatosensory and prefrontal association areas. The oxy-Hb concentration in both massages with and without aroma oil also showed a tendency to decrease with time. Our questionnaire results showed that our subjects felt more comfortable and relaxed while receiving foot care nursing with aroma oils. These results suggest that aroma oil massages are an effective foot care nursing tool and that foot care nursing is a medically effective treatment

Tumefactive multiple sclerosis requiring emergent biopsy and histological investigation to confirm the diagnosis: a case report

<p>Abstract</p> <p>Introduction</p> <p>Tumefactive multiple sclerosis is a demyelinating disease that demonstrates tumor-like features on magnetic resonance imaging. Although diagnostic challenges without biopsy have been tried by employing radiological studies and cerebrospinal fluid examinations, histological investigation is still necessary for certain diagnosis in some complicated cases.</p> <p>Case presentation</p> <p>A 37-year-old Asian man complaining of mild left leg motor weakness visited our clinic. Magnetic resonance imaging demonstrated high-signal lesions in bilateral occipital forceps majors, the left caudate head, and the left semicentral ovale on fluid-attenuated inversion recovery and T2-weighted imaging, and these lesions were enhanced by gadolinium-dimeglumin. Tumefactive multiple sclerosis was suspected because the enhancement indistinctly extended along the corpus callosum on magnetic resonance imaging and scintigraphy showed a low malignancy of the lesions. But oligoclonal bands were not detected in cerebrospinal fluid. In a few days, his symptoms fulminantly deteriorated with mental confusion and left hemiparesis, and steroid pulse therapy was performed. In spite of the treatment, follow-up magnetic resonance imaging showed enlargement of the lesions. Therefore, emergent biopsy was performed and finally led to the diagnosis of demyelinating disease. The enhanced lesion on magnetic resonance imaging disappeared after one month of prednisolone treatment, but mild disorientation and left hemiparesis remained as sequelae.</p> <p>Conclusions</p> <p>Fulminant aggravation of the disease can cause irreversible neurological deficits. Thus, an early decision to perform a biopsy is necessary for exact diagnosis and appropriate treatment if radiological studies and cerebrospinal fluid examinations cannot rule out the possibility of brain tumors.</p

Endobronchial argon plasma coagulation for the management of post-intubation tracheal stenosis

The definitive version is available at www.blackwell-synergy.com.ArticleRespirology. 11(5):659-662 (2006)journal articl