Observation of Jonscher Law in AC Hopping Conduction of Electron-Doped Nanoporous Crystal 12CaO7Al2O3 in THz Frequency Range

We have performed terahertz time-domain spectroscopy of carrier-doped nanoporous crystal 12CaO7Al2O3 showing the Mott variable range hopping at room temperature. The real part of the dielectric constant clearly demonstrates the nature of localized carriers. The frequency dependence of both the real and imaginary parts of the dielectric constant can be simply explained by assuming two contributions: a dielectric response by the parent compound with no carriers and an AC hopping conduction with the Jonscher law generally reported up to GHz range. The possible obedience to the Jonscher law in the THz range suggests a relaxation time of the hopping carriers much faster than 1ps in the carrier-doped 12CaO7Al2O3.Comment: 4pages 3figures. to be published in Phys. Rev.

Deep Sequencing of Distinct Preparations of the Live Attenuated Varicella-Zoster Virus Vaccine Reveals a Conserved Core of Attenuating Single-Nucleotide Polymorphisms

The continued success of the live attenuated varicella-zoster virus vaccine in preventing varicella-zoster and herpes zoster is well documented, as are many of the mutations that contribute to the attenuation of the vOka virus for replication in skin. At least three different preparations of vOka are marketed. Here, we show using deep sequencing of seven batches of vOka vaccine (including ZostaVax, VariVax, VarilRix, and the Oka/Biken working seed) from three different manufacturers (VariVax, GSK, and Biken) that 137 single-nucleotide polymorphism (SNP) mutations are present in all vaccine batches. This includes six sites at which the vaccine allele is fixed or near fixation, which we speculate are likely to be important for attenuation. We also show that despite differences in the vaccine populations between preparations, batch-to-batch variation is minimal, as is the number and frequency of mutations unique to individual batches. This suggests that the vaccine manufacturing processes are not introducing new mutations and that, notwithstanding the mixture of variants present, VZV live vaccines are extremely stable

Hyperbolic Ordinal Embedding

Given ordinal relations such as the object i is more similar to j than k is to l, ordinal embedding is to embed these objects into a low-dimensional space with all ordinal constraints preserved. Although existing approaches have preserved ordinal relations in Euclidean space, whether Euclidean space is compatible with true data structure is largely ignored, although it is essential to effective embedding. Since real data often exhibit hierarchical structure, it is hard for Euclidean space approaches to achieve effective embeddings in low dimensionality, which incurs high computational complexity or overfitting. In this paper we propose a novel hyperbolic ordinal embedding (HOE) method to embed objects in hyperbolic space. Due to the hierarchy-friendly property of hyperbolic space, HOE can effectively capture the hierarchy to achieve embeddings in an extremely low-dimensional space. We have not only theoretically proved the superiority of hyperbolic space and the limitations of Euclidean space for embedding hierarchical data, but also experimentally demonstrated that HOE significantly outperforms Euclidean-based methods