84 research outputs found

    サンゴ状結石に対する体外衝撃波結石破砕単独療法

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    Made available in DSpace on 2012-09-04T05:10:21Z (GMT). No. of bitstreams: 1 yamaguchi.pdf: 2349463 bytes, checksum: 27988610bb087cf256c8e97c3b0c3d55 (MD5) Previous issue date: 1995-02-1

    Fluid-rock interaction recorded in black fault rocks in the Kodiak accretionary complex, Alaska

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    Ultrafine-grained black fault rocks (BFRs) in the Pasagshak Point Thrust of the Kodiak accretionary complex are examples of fault rocks that have recorded seismicity along an ancient subduction plate boundary. Trace element concentrations and 87Sr/86Sr ratios of BFRs and surrounding foliated/non-foliated cataclasites were measured to explore the nature of fluid-rock interactions along a subduction thrust. Foliated and non-foliated cataclasites do not show significant geochemical anomalies, suggesting that they were formed by slowly distributed shear. BFRs are characterized by Li and Sr enrichment, Rb and Cs depletion, and a low 87Sr/86Sr ratio. These geochemical signatures can be explained by fluid-rock interactions at >350°C, which result in preferential removal of Rb and Cs and formation of plagioclase under the presence of fluids with high Li and Sr concentrations and low 87Sr/86Sr ratios. Geochemical anomalies recorded by the BFRs indicate both frictional heating and external fluid influx into the subduction thrust

    Apical Cl-/HCO3- exchanger stoichiometry in the modeling of HCO3- transport by pancreatic duct epithelium

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    Pancreatic duct cells secrete a HCO3--rich (~140 mM) fluid. Using a computer model of the pancreatic duct, Sohma, et al. have demonstrated that the activity of a Cl-/ HCO3- exchanger with a 1 : 1 stoichiometry at the apical membrane would have to be suppressed in order to achieve such a HCO3--rich secretion. Recently the apical exchanger in pancreatic ducts has been identified as SLC26A6 and this probably mediates most of Cl--dependent HCO3- secretion across the apical membrane. SLC26A6 is reported to mediate electrogenic Cl-/2HCO3- exchange when expressed in Xenopus oocytes. To assess the implications of this 1 : 2 stoichiometry for HCO3- secretion, we have reconstructed the Sohma model using MATLAB/Simulink. To do this we have formulated an expression for the turnover rate of Cl-/2HCO3- exchange using network thermodynamics and we have estimated the constants from published experimental data. Preliminary data suggest that the 1 : 2 stoichiometry of SLC26A6 would favor HCO3- secretion at higher concentrations

    Site-directed mutagenesis of a possible type I copper ligand of bilirubin oxidase; a Met467Gln mutant shows stellacyanin-like properties

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    金沢大学理工研究域物質化学系In our previous paper, we reported a mutant of recombinant Myrothecium verrucaria bilirubin oxidase, in which the Met467 residue was replaced by Gly. This mutant displayed a remarkable reduction in enzymatic activity and an evident decrease in the intensity of the absorption band around 600 nm (type 1 charge transfer transition). In this study, we report the preparation of three Met467 mutants (Met467Gln, Met467His, and Met467Arg) and characterize their enzymatic activities, midpoint potentials, and absorption and ESR spectra. Met467His and Met467Arg show no enzymatic activity and a great reduction in the intensity of the absorption band around 600 nm. Furthermore, their ESR spectra show no type 1 copper signal, but only a type 2 copper signal; however, oxidation by ferricyanide caused the type 1 copper signal to appear. On the other hand, Met467Gln as expressed shows both type 1 and type 2 copper signals in its ESR spectrum, the type 1 copper atom parameters being very different from usual blue copper proteins but very similar to those of stellacyanin. The enzymatic activity of the Met467Gln mutant for bilirubin is quite low (0.3%), but the activity for potassium ferrocyanide is similar (130%) to that of the wild type enzyme. These results indicate that Met467 is important for characterizing the features of the type 1 copper of bilirubin oxidase

    Identification of 45 New Neutron-Rich Isotopes Produced by In-Flight Fission of a 238U Beam at 345 MeV/nucleon

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    A search for new isotopes using in-flight fission of a 345 MeV/nucleon 238U beam has been carried out at the RI Beam Factory at the RIKEN Nishina Center. Fission fragments were analyzed and identified by using the superconducting in-flight separator BigRIPS. We observed 45 new neutron-rich isotopes: 71Mn, 73,74Fe, 76Co, 79Ni, 81,82Cu, 84,85Zn, 87Ga, 90Ge, 95Se, 98Br, 101Kr, 103Rb, 106,107Sr, 108,109Y, 111,112Zr, 114,115Nb, 115,116,117Mo, 119,120Tc, 121,122,123,124Ru, 123,124,125,126Rh, 127,128Pd, 133Cd, 138Sn, 140Sb, 143Te, 145I, 148Xe, and 152Ba

    Anelastic strain recovery reveals extension across SW Japan subduction zone

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    Sediment dominated convergent margins typically record substantial horizontal shortening often associated with great earthquakes. The convergent margin south of Japan is arguably one of the most extensively investigated margins and previous studies have documented extensive evidence for accretion and horizontal shortening. Here, we show results from anelastic strains recovered from three partially lithified sediment samples (40~ porosities) across the southwest Japan accretionary prism and propose that the margin is dominated by horizontal extension rather than compression. The anelastic strain results are also consistent with stress directions interpreted from two independent techniques - bore hole breakout orientations and core-scale fault data. We interpret this unexpected result to reflect geologically recent underthrusting of a thick sediment package and concomitant weakening of the decollement
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