The effects of Stanozolol and high protein diet on Colon Anastomosis

Background: Anastomotic leakage after colonic resection and anastomosis are serious complications with high morbidity and mortality. Collagen synthesis is an essential feature of anastomotic healing. Objective: Our study aimed to investigate individual and combined effects of high protein diet and Stanozolol on the intestinal anastomosis in rats. Methods: Total of 48 Wistar-albino rats were divided into four groups. Group C: Control group; Group P: high protein diet (4mg/day) administered by gavage; Group A: group to which stanozolol was administered intramuscularly (i.m) (2mg/kg/day); Group A+P: group to which both stanozolol (2mg/kg/day) i.m and high protein diet (4mg/day by gavage) was administered. In each group, half of the animals underwent surgery on the 3rd postoperative (PO) day and the other half on the 7th PO day for analysis procedures. Bursting pressures of each anastomotic segment, tissue hydroxyproline levels, and histologic tissue repair process were evaluated. Results: On 7th PO day, group A+P had statistically and significantly higher bursting pressures than the control group. Hydroxyproline levels at the anastomotic segment on both 3rd and 7th PO days were also significantly higher in group A+P. Conclusion: A high protein diet and stanozolol do not significantly impact the anastomotic healing when used separately. We concluded that high protein diet and Stanozolol can be used after colorectal surgery in humans but requires further research

Aktivna deformacija Zemljine površine utvrđena preciznim nivelmanskim premjerom u Afyon-Akşehir grabenu u Zapadnoj Anadoliji u Turskoj

In the actively deforming region of western Anatolia, crustal deformation is accommodated by destructive earthquakes and a variety of aseismic events. In this study, we investigated the 2016–2017 aseismic sequence located in the Bolvadin Fault, one of the segments of the Akşehir-Simav Fault System of western Anatolia by analysing surface deformation derived from detailed geological mapping. Our findings suggest that surface deformation in the Bolvadin Fault is accommodated by aseismic episodes. During the field studies in the Bolvadin area, progressive surface deformations, such as surface faults and earth fissures with a length of 800 meters to 3 kilometres and strike of N15°E to N70°E were mapped on a 1/5000 scale. Furthermore, a levelling network was established to calculate the vertical displacements and deformation rate along the surface deformations. Precision level measurements were undertaken in 2016 and 2017. On the routes to the NW of the Bolvadin settlement, a vertical deformation rate of 30 mm/yr was detected in the period of 2016–2017, and a large deformation rate of 40 mm/yr was detected in the same period.Aktivna deformacija Zemljine kore se u regiji Zapadne Anadolije kompenzira razornim potresima i drugim seizmičkim događajima. U ovom smo radu na temelju detaljnog geološkog kartiranja analizirali deformaciju površine kako bismo proučili niza seizmičkih događaja u razdoblju 2016.–2017. na lokaciji rasjeda Bolvadin, jednoga od segmenata rasjednoga sustava Akşehir-Simav u Zapadnoj Anadoliji. Naši rezultati ukazuju na to da se površinska deformacije kompenzira tijekom aseizmičkih epizoda. Tijekom terenskih istraživanja u području Bolvadin, progresivne su površinske deformacije, poput površinskih rasjeda ili pukotina duljina od 800 m do 3 km, pružanja N15°E do N70°E, kartirane u mjerilu 1:5 000. Nadalje, uspostavljena je nivelmanska mreža kako bi se izmjerila brzina pomaka i deformacija. Precizna nivelmanska mjerenja izvedena su 2016. i 2017. godine. Na pravcima usmjerenima SZ od naselja Bolvadin, ustanovljena je brzina vertikalne deformacije od 30 mm/god., a u istom je razdoblju izmjerena i velika brzina deformacije od 40 mm/god

Investigation of prognostic significance of CD44 expression in women with vulvar squamous cell carcinoma

The aim of our study is to evaluate whether CD 44 isoform expression is a prognostic factor in vulvar carcinom and to correlate the expression with clinicopathological parameters. Methods: The study included 26 patients diagnosed with invasive squamous cell vulvar cancer. The data of patients were obtained from the oncology follow-up records and the hospital database. The haemotoxylene & eosin stained preparates of the cases were removed from the archives and re-evaluated by examination of the slides under a light microscope. The preparates of the patients were evaluated separately according to the extent and intensity of staining and the combined score applied with the immunohistochemical method in the anti-CD44 antibody in the epithelium and the stroma. Results: When the CD44 epithelial staining intensity and staining combined scores of the patients were examined according to other clinicopathological parameters, a statistically significant difference was found between the groups in terms of tumour grade, differentiation, age, lymph node positivity, and survival rates (p [Med-Science 2019; 8(4.000): 774-781

The effect of the type of surgery performed due to prostate cancer on preoperative patient anxiety, a prospective study

WOS:000627038200008PubMed: 33816697Objective: Anxiety level in prostate cancer patients is common due to the increase in the incidence of prostate cancer diagnosis. We aimed to search for answers to the following questions such as whether there is preoperative anxiety in patients who will be operated for prostate cancer, what are the risk factors that may cause disease-induced anxiety and the type of surgery especially does robotic surgery reduce patient anxiety. Method: The patients who were taken into operation were divided into 2 groups as Open Radical Retropubic Prostatectomy-Group 1 and Robot-Assisted Laparoscopic Radical Prostatectomy-Group 2. Age, active surveillance history, preoperative prostate spesific antigen (PSA) level, prostate biopsy pathology result, time between prostate biopsy and operation, state and trait anxiety scores of these patients were recorded. Result: The study was conducted with a total of 149 patients; 61 patients in Group 1 and 88 patients in Group 2. The presence of active surveillance history, time between prostate biopsy and operation and state and trait anxiety levels were not found to be significant between both groups. However, it was concluded that the patients in Group 2 were significantly younger and operated with lower PSA and Gleason scores. The type of surgery had no effect on anxiety levels. Conclusion: Preoperative information about the surgical procedure was found to be an effective factor in reducing anxiety. Regardless of the type of surgery we recommend that patients' anxiety should be reduced by explaining the surgical procedure to patients enough and in a way that they can understand

The Role of Hematological Parameters in Predicting Fuhrman Grade and Tumor Stage in Renal Cell Carcinoma Patients Undergoing Nephrectomy

Background and objective: We investigated the ability of preoperative serum values of red blood cell distribution width (RDW), neutrophil lymphocyte ratio (NLR) and plateletcrit (PCT) to predict Fuhrman grades (FG) and tumor stages of renal cell carcinoma in patients who underwent radical nephrectomy. Materials and methods: Records of 283 patients that underwent radical or partial nephrectomy of renal masses at our clinic between January 2010 and April 2018, whose pathology results indicated renal cell carcinoma (RCC), and who had their FG and T1–4 N0M0 identified were retrospectively evaluated. The patients were divided into two groups based on their FG as low (I–II) and high (III–IV) and their T stages were similarly grouped as limited to kidney (pT1–pT2) and not limited to kidney (pT3–pT4). Results: Mean RDW, NLR, PCT cut-off values of the patients for FG and T stage were 15.65%, 3.54, 0.28% and 14.35%, 2.69, 0.28%, respectively. The RDW and NLR were determined to be statistically significant predictors of a pathologically high FG, whereas the PCT value was not a statistically significant predictor of high FG (p = 0.003, p = 0.006, p = 0.075, respectively). The relationship of RDW, NLR and PCT values with a limited to the kidney pathological T stage revealed statistically significant correlations for all three values. Conclusions: We determined that only RDW and NLR were markers predicting FG, while PCT had no prognostic value. On the other hand, all three of these values were associated with a limited to the kidney pathological T stage in patients who underwent nephrectomy due to renal masses and whose pathologies suggested RCC

Tear Nitric Oxide Levels in Behcet's Disease

The aim of this study was to evaluate the tear nitric oxide (NO) level in patients with Behcet's disease and to compare it with that in healthy subjects

Management of Priapism: Results of a Nationwide Survey and Comparison with International Guidelines

Objective: The aim of this study is to evaluate current urologic practice regarding the management of priapism in Turkey and compare with international guidelines. Methods: Urologists and urology residents were invited to an online survey consisting of 30 multiple-choice questions on priapism-related clinical practices that were considered most important and relevant to practices by using Google Forms. Results: Total number of responses was 340. Respondents reported that they recorded a detailed patient’s medical history and physical examination findings (n = 340, 100%) and laboratory testing, which includes corporal blood gas analysis (n = 323, 95%). Participants announced that they performed Doppler ultrasound for 1/4 cases (n = 106, 31%), but 22% of the participants (n = 75) replied that they performed in >75% of cases. Participants (n = 311, 91%) responded that the first-line treatment of ischemic priapism is decompression of the corpus cavernosum. Moreover, most respondents (n = 320, 94%) stated that sympathomimetic injection drugs should be applied as the second step. About three-quarters of respondents (n = 247, 73%) indicated adrenaline as their drug of choice. Phosphodiesterase type 5 inhibitors seems to be the most preferred drug for stuttering priapism (n = 141, 41%). Participants (n = 284, 84%) replied that corpora-glanular shunts should be preferred as the first. A large number of participants (n = 239, 70%) declared that magnetic resonance imaging can be performed in cases with delayed (>24 hours) priapism to diagnose corporal necrosis. Most of the participants (84%) responded that penile prosthesis should be preferred to shunts in cases with delayed (>48 hours) priapism. Conclusion: It would be appropriate to improve the training offered by professional associations and to give more training time to the management of priapism during residency