SIRANE modeling of oxides nitrogen (NOx) and ozone (O3) in the area of Agadir city, southwestern Morocco.

This work aimed to model the dispersion of the traffic emissions for the first time in the area of Agadir city (Morocco). The estimate of road emission (from vehicle counts) was performed with Circul’air software version 4.0 which is based on the European methodology Copert 4. While the dispersion modelling was performed using SIRANE model, an important tool which adopts the classic NOx photochemical process. The input data are pollutant emissions, background concentrations, meteorological parameters and building configuration data from QGIS software as well as a list of other factors such as latitude, albedo, etc.   Finally, the quality of the output results was validated by comparing observed measurements and modelled data

Accident vasculaire cerebral ischemique post-chimiotherapie pour cancer du sein

IntroductionLa chimiothérapie anticancéreuse est pourvoyeuse d’un large spectre de complications neurologiques. Parmi ces complications les accidents vasculaires cérébraux ischémiques (AVCI) restent un évènement inhabituel dont l’incidence est de 0,14%.ObjectifRapporter et commenter l’observation d’une patiente ayant présenté un AVCI dans les suites d’une chimiothérapie pour cancer du sein.ObservationPatiente âgée de 46ans, traitée pour une épilepsie généralisée, et sans facteur de risque cardiovasculaire, est suivie pour un cancer du sein. Elle a présenté au décours de la chimiothérapie un accident vasculaire cérébral ischémique sylvien droit confirmé au scanner cérébral. Les explorations cardiaques sont normales, ainsi que le bilan biologique étiologique.DiscussionLe diagnostic d’AVC post-chimiothérapie a été retenu chez notre patiente sur la base de l’absence de facteur de risque vasculaire et la négativité du bilan étiologique, ainsi que l’usage du 5 Fluorouracile qui a été incriminé dans la survenue d’AVC ischémiques. La survenue de cette complication dépend du type de drogue utilisé, et de certaines associations thérapeutiques, et relèverait de plusieurs mécanismes pouvant être intriqués. Le bilan doit être le plus complet possible afin d’affirmer l’imputabilité de la chimiothérapie.ConclusionNotre observation souligne la sévérité des complications neurologiques de la chimiothérapie, ainsi que le dilemme thérapeutique posé, en l’absence de protocole de prise en charge codifié.Mots clés : Accident vasculaire cérébral, cancer du sein, chimiothérapie, toxicité, 5-Fluorouracil

Improved flux limits for neutrinos with energies above 1022^{22} eV from observations with the Westerbork Synthesis Radio Telescope

Particle cascades initiated by ultra-high energy (UHE) neutrinos in the lunar regolith will emit an electromagnetic pulse with a time duration of the order of nano seconds through a process known as the Askaryan effect. It has been shown that in an observing window around 150 MHz there is a maximum chance for detecting this radiation with radio telescopes commonly used in astronomy. In 50 hours of observation time with the Westerbork Synthesis Radio Telescope array we have set a new limit on the flux of neutrinos, summed over all flavors, with energies in excess of $4\times10^{22}$ eV.Comment: Submitted to Phys. Rev. Let

Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics

Alcohol dehydrogenases (ADH) participate in the biosynthetic pathway of aroma volatiles in fruit by interconverting aldehydes to alcohols and providing substrates for the formation of esters. Two highly divergent ADH genes (15% identity at the amino acid level) of Cantaloupe Charentais melon (Cucumis melo var. Cantalupensis) have been isolated. Cm-ADH1 belongs to the medium-chain zinc-binding type of ADHs and is highly similar to all ADH genes expressed in fruit isolated so far. Cm-ADH2 belongs to the short-chain type of ADHs. The two encoded proteins are enzymatically active upon expression in yeast. Cm-ADH1 has strong preference for NAPDH as a co-factor, whereas Cm-ADH2 preferentially uses NADH. Both Cm-ADH proteins are much more active as reductases with Kms 10–20 times lower for the conversion of aldehydes to alcohols than for the dehydrogenation of alcohols to aldehydes. They both show strong preference for aliphatic aldehydes but Cm-ADH1 is capable of reducing branched aldehydes such as 3-methylbutyraldehyde, whereas Cm-ADH2 cannot. Both Cm-ADH genes are expressed specifically in fruit and up-regulated during ripening. Gene expression as well as total ADH activity are strongly inhibited in antisense ACC oxidase melons and in melon fruit treated with the ethylene antagonist 1-methylcyclopropene (1-MCP), indicating a positive regulation by ethylene. These data suggest that each of the Cm-ADH protein plays a specific role in the regulation of aroma biosynthesis in melon fruit

Identification of multiple root disease resistant wheat germplasm against cereal nematodes and dryland root rot and their validation in regions of economic importance

História da literatura portuguesa coordenada por Giulia Lanciani - primeiras páginas de um total pp. 7-108)História literária do século XVIII portuguêsGoverno de Portuga