The anatomy of urban social networks and its implications in the searchability problem

The appearance of large geolocated communication datasets has recently increased our understanding of how social networks relate to their physical space. However, many recurrently reported properties, such as the spatial clustering of network communities, have not yet been systematically tested at different scales. In this work we analyze the social network structure of over 25 million phone users from three countries at three different scales: country, provinces and cities. We consistently find that this last urban scenario presents significant differences to common knowledge about social networks. First, the emergence of a giant component in the network seems to be controlled by whether or not the network spans over the entire urban border, almost independently of the population or geographic extension of the city. Second, urban communities are much less geographically clustered than expected. These two findings shed new light on the widely-studied searchability in self-organized networks. By exhaustive simulation of decentralized search strategies we conclude that urban networks are searchable not through geographical proximity as their country-wide counterparts, but through an homophily-driven community structure

Analysis of surface extraction methods based on gradient operators for computed tomography in metrology applications

Among the multiple factors influencing the accuracy of Computed Tomography measurements, the surface extraction process is a significant contributor. The location of the surface for metrological applications is generally based on the definition of a gray value as a characteristic of similarity to define the regions of interest. A different approach is to perform the detection or location of the surface based on the discontinuity or gradient. In this paper, an adapted 3D Deriche algorithm based on gradient information is presented and compared with a previously developed adapted Canny algorithm for different surface types. Both algorithms have been applied to nine calibrated workpieces with different geometries and materials. Both the systematic error and measurement uncertainty have been determined. The results show a significant reduction of the deviations obtained with the Deriche-based algorithm in the dimensions defined by flat surfaces

Inhibition of γ-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells

γ-Secretase activity is vital for the transmembrane cleavage of Notch receptors and the subsequent migration of their intracellular domains to the nucleus. Notch overexpression has been associated with breast, colon, cervical and prostate cancers. We tested the effect of three different γ-secretase inhibitors (GSIs) in breast cancer cells. One inhibitor (GSI1) was lethal to breast cancer cell lines at concentrations of 2 μM and above but had a minimal effect on the non-malignant breast lines. GSI1 was also cytotoxic for a wide variety of cancer cell lines in the NCI60 cell screen. GSI1 treatment resulted in a marked decrease in γ-secretase activity and downregulation of the Notch signalling pathway with no effects on expression of the γ-secretase components or ligands. Flow cytometric and western blot analyses indicated that GSI1 induces a G2/M arrest leading to apoptosis, through downregulation of Bcl-2, Bax and Bcl-XL. GSI1 also inhibited proteasome activity. Thus, the γ-secretase inhibitor GSI1 has a complex mode of action to inhibit breast cancer cell survival and may represent a novel therapy in breast cancer

Setting conclitions, Petrology ancl Geochemistry of calc-alkaline rhyolites, stephanian-permian, in the iberian chains

[Resumen] Se exponen los caracteres del emplazamiento, la composición petrológica y geoquímica de unos sills riolíticos que, con afinidad calco-alcalina, se emplazaron, bajo un ambiente sin-colisional, en diversos sectores de la Cadena Ibérica. Estas riolitas representan un origen crustal, con baja tasa de fusión, previo a un magmatismo calco-alcalino de origen subcrustal.[Abstract] The setting characters, the petrological and geochemical composition are exposed for sorne rhyolitic sills, with calc-alkaline affinity, which were set, in a syncollisional environment, in several areas of the Iberian Chains. These rhyolites represent a crustal origin, with a low degree of fussion, previous to a calc-alkaline magmatism of subcrustal origino

Reference standard for the uncertainty estimation of X–ray Computed Tomography measurements of complex macro-and micro-geometries

Traditionally, measuring both macro and micro geometries with a single device has been challenging in metrology. Coordinate Measuring Machines (CMM) are common devices for the inspection of large features, while optical microscopes can achieve resolutions in the order of micrometers in small areas. X-Ray Computed Tomography (XCT) has become a solution not only to characterize both micro and macro geometries, but also to inspect internal features without destroying the sample. In this field, various reference standards have been developed in order to verify the capabilities of XCT systems, these artefacts include geometrical features or profiles for roughness inspection. This paper shows the design and develompent of a reference standard for XCT test which includes internal and external geometrical features and profiles for macro and micro geometrical inspection. The model is manufactured by additive manufacturing (AM), easing the process of fabrication of the artefact and allowing to test the capabilities of this technology to produce reference standards

Preliminary comparison of magmatic manifestations, calc-alkaline affinity and stephanian-permian age, in the Iberian Chain

[Resumen] En este trabajo se estudian, de forma sintética y actualizada, las manifestaciones (hipovolcánicas y volcanoclásticas) calco-alcalinas que, con carácter epizonal, pluriepisódico y edad Stephaniense-Pérmico, afloran en la Cadena Ibérica. El estudio del magmatismo en la cuenca de Sauquillo de Alcázar (Soria) permite identificar la geometría y la modalidad de este magmatismo con mayor precisi6n, respecto a lo obtenido en los cuatro afloramientos volcano-clásticos seleccionados. Los resultados obtenidos facilitan realizar consideraciones sobre el estudio espacio-temporal de este magmatismo..[Abstract] A synthetic and actualized study of several magmatic calc-alkaline manifestations of Stephanian-Permian age, of the Iberian Chain, is proposed in this papero The Sauquillo de Alcázar (Soria) outcrop allows a more complete study (with drilling logs and a surface profile) giving improved spacetime information on the geometry and evolution of this magmatism. Four pyroclastic outcrops are integrated in this compariso

Triassic tholeiitic dolerites («ophites») of the El Grado diapir (Pyrenees, Huesca, Spain): emplacement and composition

Mesozoic dolerites in the south Pyrenean sector of El Grado (Huesca, Spain) preserve emplacement structures (fluidity structures at the top and load structures at the base) developed during their intrusion into unconsolidated marly-evaporitic Triassic sediments (Keuper facies). By analogy with other dolerites in the south Pyrenean domain, their emplacement age is equivalent to the uppermost Keuper facies terms, but prior to the final Triassic-early Liassic carbonated sediments. Radiometric ages (187-197±7 Ma) show that the emplacement occurred during the lower Liassic. The petralogical differentiation from the chilled margin facies to the central facies, and also to the late pegmatitoids, is consistent with that obtained from major elements, trace elements and REE. Their tholeiitic affinity, as defined by their geochemical composition, is equivalent to that of similar racks in the Pyrenean domain. However, the rocks analyzed here, which are located at the external sector of this domain, display a greater petralogical and geochemical differentiation as compared to similar rocks in the central sectors of the Pyrenean domain.Las doleritas mesozoicas del sector surpirenaico de El Grado (Huesca) conservan estructuras de emplazamiento (con desarrollo del movimiento de lava fluida al techo y de carga en su base) desarrolladas al instruir en los sedimentos margo-evaporíticos en facies Keuper, todavía inconsolidados. Por similitud con otras doleritas del dominio surpirenaico, la edad del emplazamiento es equivalente a la de los términos superiores de la facies Keuper y previa a la sedimentación carbonatada del Trías terminal-Lías inferior. Las determinaciones de edades radiométricas (187-197±7 Ma) indican que el emplazamiento debió tener lugar durante el Lías inferior. La diferenciación petralógica, desde la facies del borde enfriado a la central y, también, al posterior diferenciado pegmatoide concuerda con la obtenida con elementos mayores, trazas y REE. Su afinidad toleítica, definida por su composición geoquímica, coincide con la obtenida en rocas análogas para el dominio pirenaico; no obstante, estas rocas situadas en el borde más externo de dicho dominio representan una mayor diferenciación (petralógica y geoquímica) respecto a la obtenida, hasta el momento, para rocas análogas situadas en sectores más centrales del citado dominio pirenaico

The triassic alkaline dolerites of the Valacloche-Camarena Area (SE-Iberian Chain, Teruel): Geodynamic implications

The dolerite sills outcropping in the Valacloche-Camarena area (SE Iberian Chain), are the expression of an alkaline magmatism, emplaced in Keuper facies sedimentary rocks. Their pre-Hettangian age is deduced from the development of fluidality structures at the top of the sills together with the very low grade contact metamorphism of the host rocks. A differentiation trend, represented by two rock-types, with variable Ti-augite content, is confirmed by geochemical data (REE). The alkaline composition of this magmatism is close to that of the OIB type. Crust-derived enclaves (metapelites and granitoids) are common in these sills, suggesting that magma ascent took place through a fracture system, related to a distensive tectonic regime, that affected different levels of the crust. This magmatism was one of the expressions of the triassic rifting events that are well represented in the SE border of the Iberian Chain.Un magmatismo alcalino, emplazado en sedimentos triásicos en facies Keuper, está bien representado en los sills doleríticos del área de Valacloche-Camarena (SE de la Cordillera Ibérica). La edad pre-Hettangiense ha sido deducida a partir de la presencia de estructuras de fluidalidad y de un metamorfismo de contacto de grado muy débil. Petrológicamente se identifica una fraccionación según dos litotipos (con contenido variable en Ti-augita) que está corroborada por los datos de composición geoquímica (en tierras raras); la composición alcalina de este magmatismo es próxima a la del tipo OIB. La presencia, frecuente, de enclaves de corteza (metapelitas y granitoides) indica una fracturación que, en condiciones distensivas, afectó a distintos niveles de dicha corteza. Este magmatismo está ligado al rifting triásico que está bien expresado en el borde SE de la Cordillera Ibérica

A Testpart for Interdisciplinary Analyses in Micro Production Engineering

AbstractIn 2011, a round robin test was initiated within the group of CIRP Research Affiliates. The aim was to establish a platform for linking interdisciplinary research in order to share the expertise and experiences of participants all over the world. This paper introduces a testpart which has been designed to allow an analysis of different manufacturing technologies, simulation methods, machinery and metrology as well as process and production planning aspects. Current investigations are presented focusing on the machining and additive processes to produce the geometry, simulation approaches, machine analysis, and a comparison of measuring technologies. Challenges and limitations regarding the manufacturing and evaluation of the testpart features by the applied methods are discussed.Video abstrac