180 research outputs found
Influence of Doping Concentrations in White Organic Light-emitting Diodes based on Phosphorescent Iridium Complexes
AbstractPhosphorescent white organic light-emitting diodes (PhWOLEDs) based on blue (Firpic) and yellow [(t-bt)2Ir(acac)] phosphorescent emitters with various doping concentration were reported. A PhWOLED with high performance characteristics has been obtained when the doping concentration for Firpic and (t-bt) 2Ir (acac) is 8 wt% and at 6 wt%, respectively. The Commission Internationale del’Eclairage (CIE) coordinates of the optimal PhWOLED is (0.333, 0.416) at 10V. The high performance of the optimized PhWOLED is attributed to effective host-guest energy transfer and efficient exciton recombination combining with suppressed exciton-quenching process in the emitting layers
Hydrodeoxygenation of Methyl Laurate over Ni Catalysts Supported on Hierarchical HZSM-5 Zeolite
The hierarchical HZSM-5 zeolite was prepared successfully by a simple NaOH treatment method. The concentration of NaOH solution was carefully tuned to optimal the zeolite acidity and pore structure. Under NaOH treatment conditions, a large number of mesopores, which interconnected with the retained micropores, were created to facilitate mass transfer performance. There are very good correlations between the decline of the relative zeolite crystallinity and the loss of micropores volume. The Ni nanoclusters were uniformly confined in the mesopores of hierarchical HZSM-5 by the excessive impregnation method. The direct deoxygenation in N2 and hydrodeoxygenation in H2 of the methyl laurate were compared respectively over the Ni/HZSM-5 catalysts. In the N2 atmosphere, the deoxygenation rate of the methyl laurate on the Ni/HZSM-5 catalyst is relatively slow. In the presence of H2, the synergistic effect between the hydrogenation function of the metal and the acid function of the zeolite supports can make the deoxygenation level more obvious. The yield of hydrocarbon products gradually reached the maximum with the appropriate treatment concentration of 1M NaOH, which could be attributed to the improved mass transfer in the hierarchical HZSM-5 supports
Direct observation of magnon-phonon coupling in yttrium iron garnet
The magnetic insulator yttrium iron garnet (YIG) with a ferrimagnetic
transition temperature of 560 K has been widely used in microwave and
spintronic devices. Anomalous features in the spin Seeback effect (SSE)
voltages have been observed in Pt/YIG and attributed to the magnon-phonon
coupling. Here we use inelastic neutron scattering to map out low-energy spin
waves and acoustic phonons of YIG at 100 K as a function of increasing magnetic
field. By comparing the zero and 9.1 T data, we find that instead of splitting
and opening up gaps at the spin wave and acoustic phonon dispersion
intersecting points, magnon-phonon coupling in YIG enhances the hybridized
scattering intensity. These results are different from expectations of
conventional spin-lattice coupling, calling for new paradigms to understand the
scattering process of magnon-phonon interactions and the resulting
magnon-polarons.Comment: 5 pages, 4 figures, PRB in pres
Nucleolin links to arsenic-induced stabilization of GADD45α mRNA
The present study shows that arsenic induces GADD45α (growth arrest and DNA damage inducible gene 45α) mainly through post-transcriptional mechanism. Treatment of the human bronchial epithelial cell line, BEAS-2B, with arsenic(III) chloride (As(3+)) resulted in a significant increase in GADD45α protein and mRNA. However, As(3+) only exhibited a marginal effect on the transcription of the GADD45α gene. The accumulation of GADD45α mRNA is largely achieved by the stabilization of GADD45α mRNA in the cellular response to As(3+). As(3+) is able to induce binding of mRNA stabilizing proteins, nucleolin and less potently, HuR, to the GADD45α mRNA. Although As(3+) was unable to affect the expression of nucleolin, treatment of the cells with As(3+) resulted in re-distribution of nucleolin from nucleoli to nucleoplasm. Silencing of the nucleolin mRNA by RNA interference reversed As(3+)-induced stabilization of the GADD45α mRNA and accumulation of the GADD45α protein. Stabilization of GADD45α mRNA, thus, represents a novel mechanism contributing to the production of GADD45α and cell cycle arrest in response to As(3+)
MeDReaders: a database for transcription factors that bind to methylated DNA
Understanding the molecular principles governing interactions between transcription factors (TFs) and DNA targets is one of the main subjects for transcriptional regulation. Recently, emerging evidence demonstrated that some TFs could bind to DNA motifs containing highly methylated CpGs both in vitro and in vivo. Identification of such TFs and elucidation of their physiological roles now become an important stepping-stone toward understanding the mechanisms underlying the methylation-mediated biological processes, which have crucial implications for human disease and disease development. Hence, we constructed a database, named as MeDReaders, to collect information about methylated DNA binding activities. A total of 731 TFs, which could bind to methylated DNA sequences, were manually curated in human and mouse studies reported in the literature. In silico approaches were applied to predict methylated and unmethylated motifs of 292 TFs by integrating whole genome bisulfite sequencing (WGBS) and ChIP-Seq datasets in six human cell lines and one mouse cell line extracted from ENCODE and GEO database. MeDReaders database will provide a comprehensive resource for further studies and aid related experiment designs. The database implemented unified access for users to most TFs involved in such methylation-associated binding actives. The website is available at http://medreader.org/
Electric-field-driven Non-volatile Multi-state Switching of Individual Skyrmions in a Multiferroic Heterostructure
Electrical manipulation of skyrmions attracts considerable attention for its
rich physics and promising applications. To date, such a manipulation is
realized mainly via spin-polarized current based on spin-transfer torque or
spin-orbital torque effect. However, this scheme is energy-consuming and may
produce massive Joule heating. To reduce energy dissipation and risk of
heightened temperatures of skyrmion-based devices, an effective solution is to
use electric field instead of current as stimulus. Here, we realize an
electric-field manipulation of skyrmions in a nanostructured
ferromagnetic/ferroelectrical heterostructure at room temperature via an
inverse magneto-mechanical effect. Intriguingly, such a manipulation is
non-volatile and exhibits a multi-state feature. Numerical simulations indicate
that the electric-field manipulation of skyrmions originates from
strain-mediated modification of effective magnetic anisotropy and
Dzyaloshinskii-Moriya interaction. Our results open a direction for
constructing low-energy-dissipation, non-volatile, and multi-state
skyrmion-based spintronic devices.Comment: Accepted by Nature Communications 11, 3577 (2020
Functional Divergence among Silkworm Antimicrobial Peptide Paralogs by the Activities of Recombinant Proteins and the Induced Expression Profiles
Antimicrobial peptides are small-molecule proteins that are usually encoded by multiple-gene families. They play crucial roles in the innate immune response, but reports on the functional divergence of antimicrobial peptide gene families are rare. In this study, 14 paralogs of antimicrobial peptides belonging to cecropin, moricin and gloverin families were recombinantly expressed in pET expression systems. By antimicrobial activity tests, peptides representing paralogs in the same family of cecropin and moricin families, displayed remarkable differences against 10 tested bacteria. The evolutionary rates were relatively fast in the two families, which presented obvious functional divergence among paralogs of each family. Four peptides of gloverin family had similar antimicrobial spectrum and activity against tested bacteria. The gloverin family showed similar antimicrobial function and slow evolutionary rates. By induced transcriptional activity, genes encoding active antimicrobial peptides were upregulated at obviously different levels when silkworm pupae were infected by three types of microbes. Association analysis of antimicrobial activities and induced transcriptional activities indicated that the antimicrobial activities might be positively correlated with induced transcriptional activities in the cecropin and moricin families. These results suggest that representative BmcecB6, BmcecD and Bmmor as the major effector genes have broad antimicrobial spectrum, strong antimicrobial activity and high microbe-induced expression among each family and maybe play crucial roles in eliminating microbial infection
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