Introducing Three Tier Captcha to Prevent DDOS Attack in Cloud Computing

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Improvement of Voltage Profile and Loss Reduction Using Optimized Soft Computing Based Capacitor Placement Methodology

Significant exploration has been done on the arrangement of ideal capacitor arranging in the appropriation frameworks for the assignments of power factor adjustment, voltage profile improvement and misfortune decrease. Particularly, mechanical plant with variable load conditions has huge inductive loads and its power factor is exceptionally poor. These ventures advantage most capacitor banks. This bank gives improved power factor, expanded voltage level on the load and lessen the electric service bills. Moreover, programmed capacitor banks might be ready to dispose of kVAr stimulated at light-load periods and bothersome over-voltages. In most cases, the primary motivation behind why a client introduces a capacitor bank is to maintain a strategic distance from punishment in the power bill. Power factor is a proportion of the genuine power to evident power, and speaks to how a lot genuine power electrical gear uses. A power factor of any worth other than solidarity is brought about by inductive or capacitive reactance and harmonics in the circuit [2]. The expansion in power request and high load thickness in the urban zones makes the activity of power frameworks muddled. To fulfill the load need, the framework is required to extend by expanding the substation limit and the quantity of feeders. Notwithstanding, this may not be handily accomplished for some utilities because of different requirements. Along these lines, to give more limit edge for the substation to fulfil load need, framework misfortune minimization procedures are utilized. In addition, the impact of electric power misfortune is that heat energy is dispersed which builds the temperature of the related electric parts and can bring about protection disappointment. By limiting the power misfortunes, the framework may secure longer life expectancy and have dependability that is more prominent. Different techniques have been utilized to decrease power misfortunes financially by ideal choice of size, area and cost of capacitor bank

Mental Disability: A Retrospective Study of Socio-Clinical Profile of Patients Seeking Disability Certificate at a Tertiary Care Centre in Delhi

Background: Mental illness and mental retardation are included in "The persons with disabilities (Equal opportunities, protection of rights and full participation) Act, 1995” along with other causes of disabilities like blindness, hearing impairment, locomotor disability etc. The persons with disability are eligible for various social welfare benefits from the Government under this act if they have minimum 40% disability as certified by a Government medical authority. This is among one of the few studies on various mental disability related variables and socio-clinical profile of disability certificate seeking patients and is probably the only one to compare results with a similar kind of study done at the same centre five years ago.Objective: The study aims to assess the socio-demographic profile of the cases, severity of disability in the mentally retarded and mentally ill, co-morbid psychiatric and medical conditions, pattern of utilization of different government benefits and to compare results of current study with a study done at the same centre five years ago.Materials and Methods: The study was carried out in the Department of Psychiatry of a tertiary care multispecialty teaching hospital in New Delhi. This was a retrospective file-review based study of patients who were issued disability certificate for Mental retardation or Mental illness during January, 2015 to May, 2016. The subjects were diagnosed to be suffering from Mental retardation or Mental illness as per ICD-10 and disability was assessed as per guidelines issued by Government of India in 2001 for Mental retardation and for Mental illness in 2002. Indian Disability Evaluation and Assessment Scale (IDEAS) was used to assess disability in Mental illness cases.Statistical Analysis: The statistical analysis was done by using WHO'S Epi Info version 7.2. Frequency, percentages, t test and chi-square analysis were used to analyze the data.Results: Out of total 231 cases, majority were male 163 (70.6%), Hindu 211 (91.3%), under 18 years of age 160 (69.3%), unmarried 228 (98.7%), lived in nuclear family 186 (80.5%), from urban background 137 (59.3%). Total number of cases of Mental retardation were 220 (95.2%), 11 (4.7%) cases were of Mental illness.Severity wise in Mental Retardation group (220 cases) maximum number of cases were of Mild Mental Retardation 94(42.7%) having 50% disability, in Mental illness group 10 out of 11 cases had moderate disability (40-70% disability as per IDEAS Scoring). Medical co-morbidity was present in 22(9.5%) cases mainly in the form of Cerebral palsy, Epilepsy; 24(10.4%) patients had psychiatric co-morbidity in the form of Behavior problems, Attention Deficit Hyperactivity Disorder (ADHD), Conduct disorder. Maximum number of patients 177(76.6%) applied to get Monthly allowance. On comparison with a similar study done at the same centre five years back, the significant difference was low mean age of sample and increased rural representation in the present study and both the differences were statistically significant.Conclusion: Number of patients seeking disability certificate has risen as compared to previous study. Majority of the cases were male, mostly from urban background although rural representation in comparison to previous (2011) study has increased significantly. Cases of Mental Retardation outnumbers patients with Mental illness seeking disability certificates reflecting more number of Mental illness cases seeking treatment early in the course of illness and availability of better treatment options.Information related to disability and various beneficiary schemes by Government of India needs to be provided in detail so that maximum number of cases can avail other benefits along with monetary one

Boswellic Acid Suppresses Growth and Metastasis of Human Pancreatic Tumors in an Orthotopic Nude Mouse Model through Modulation of Multiple Targets

Pancreatic cancer (PaCa) is one of the most lethal cancers, with an estimated 5-year survival of <5% even when patients are given the best treatment available. In addition, these treatments are often toxic and expensive, thus new agents which are safe, affordable and effective are urgently needed. We describe here the results of our study with acetyl-11-keto-β-boswellic acid (AKBA), an agent obtained from an Ayurvedic medicine, gum resin of Boswellia serrata. Whether AKBA has an activity against human PaCa, was examined in in vitro models and in an orthotopic nude mouse model of PaCa. We found that AKBA inhibited the proliferation of four different PaCa cell lines (AsPC-1, PANC-28, and MIA PaCa-2 with K-Ras and p53 mutations, and BxPC-3 with wild-type K-Ras and p53 mutation). These effects correlated with an inhibition of constitutively active NF-κB and suppression of NF-κB regulating gene expression. AKBA also induced apoptosis, and sensitized the cells to apoptotic effects of gemcitabine. In the orthotopic nude mouse model of PaCa, p.o. administration of AKBA alone (100 mg/kg) significantly inhibited the tumor growth; this activity was enhanced by gemcitabine. In addition, AKBA inhibited the metastasis of the PaCa to spleen, liver, and lungs. This correlated with decreases in Ki-67, a biomarker of proliferation, and CD31, a biomarker of microvessel density, in the tumor tissue. AKBA produced significant decreases in the expression of NF-κB regulating genes in the tissues. Immunohistochemical analysis also showed AKBA downregulated the expression of COX-2, MMP-9, CXCR4, and VEGF in the tissues. Overall these results demonstrate that AKBA can suppress the growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model that correlates with modulation of multiple targets

Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer

Traditional medicine and diet has served mankind through the ages for prevention and treatment of most chronic diseases. Mounting evidence suggests that chronic inflammation mediates most chronic diseases, including cancer. More than other transcription factors, nuclear factor-kappaB (NF-κB) and STAT3 have emerged as major regulators of inflammation, cellular transformation, and tumor cell survival, proliferation, invasion, angiogenesis, and metastasis. Thus, agents that can inhibit NF-κB and STAT3 activation pathways have the potential to both prevent and treat cancer. In this review, we examine the potential of one group of compounds called triterpenes, derived from traditional medicine and diet for their ability to suppress inflammatory pathways linked to tumorigenesis. These triterpenes include avicins, betulinic acid, boswellic acid, celastrol, diosgenin, madecassic acid, maslinic acid, momordin, saikosaponins, platycodon, pristimerin, ursolic acid, and withanolide. This review thus supports the famous adage of Hippocrates, “Let food be thy medicine and medicine be thy food”

Lung cancer metastasis to oral soft tissues; Systematic review of 122 cases

Lung cancer metastasis to oral region is very rare. Studies have been published analysing the cases of metastatic tumours to the oral cavity by many researchers. But very few research work has been conducted till date to analyse only the oral soft tissu

PHENO-GENOTYPIC CHARACTERIZATION OF LISTERIA MONOCYTOGENES FROM BOVINE CLINICAL MASTITIS

ABSTRACT The present study was carried out for pheno-genotypic characterization of L. monocytogenes (L. monocytogenes). A total of three isolates of L. monocytogenes were recovered from 85 mastitic milk samples (47 buffalos and 38 cows). Confirmation of the L. monocytogenes were based on biochemical tests followed by phenotypic characterization by hemolysis on sheep blood agar, the Christie Atkins Munch-Petersen (CAMP) test, phosphatidylinositol-specific phospholipase C (PIPLC) assay and phosphatidylcholine-specific phospholipase C (PIPLC) assay. The isolates were subjected to genotypic characterization with the help of PCR assay for five virulence associated genes namely, plcA, prfA, hlyA, actA and iap. The L. monocytogenes isolates were further subjected to multiplex-PCR based serotyping. All the three isolates of L. monocytogenes were hemolytic, CAMP positive, PI-PLC, PC-PLC positive, hlyA, pclA, actA, iap and prfA positive by PCR. All the three isolates of L. monocytogenes were serotyped as 4b

Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake (vol 80, vol 1021, 2010)

Retraction notice to “Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake” [Biochem. Pharmacol. 80 (2010) 1021–1032].Non peer reviewe

Effect of Electromagnetic Field on Antimicrobial Activity and Novel Antimicrobial Compounds

The objective of this study is to determine the antimicrobial activity of the essential oils and effect of electromagnetic field on the activity. To find out antimicrobial activity of essential oils (Thyme, Clove, Lavender), against test organisms disc diffusion assay was performed. MIC of all essential oils were determined under electromagnetic field and non-electromagnetic field. Both studies confirmed the antimicrobial activity of oils and effect of electromagnetic field. However, time killing experiment was conducted to calculate rate of inhibition for essential oils, lavender oil and thyme oil showed higher rate as compared to that of clove oil. This study provides evidence to antimicrobial activity of essential oils, and also confirmed the effect of electromagnetic field on the activity. The proposed mechanism for antimicrobial activity is inhibition of metabolic enzymes which has supported with Analytical Profile Identification (API 20NE)

Groundwater hydrochemistry of Rajnandgaon district, Chhattisgarh, Central India

The spreading of fluorosis diseases in Central India related to high concentrations of fluoride ion (F−) is a cause of major concern. In this work, the hydrochemistry of the aquifers related to Seonath River, in Rajnandgaon district, Chhattisgarh state, India, has been studied, focusing on the presence and sources of F−. Hydrochemical parameters were analyzed in the post-monsoon season in 160 wells located in nine tehsils, finding F− concentrations ranging from 0.6 to 18.5 mg L−1. Seasonal variations were also studied in Chhuikhadan tehsil, in which the highest F− values were registered, finding a noticeable enrichment in the pre-monsoon months. In many locations of the district, F− concentrations exceeded the recommended value of 1.5 mg L−1, which have led to the appearance of several health issues. Multidimensional analysis statistical methods were adopted to investigate the sources of F−, and the mineralization of bedrock elements into the groundwater was observed to be the primary source