Video assisted thoracoscopy surgery a viable alternative for duplication cyst excision: a case report on foregut duplication cyst

Alimentary tract duplication is a relatively uncommon congenital abnormality. It can be found anywhere from the mouth to the anus and can be symptomatic or undetectable. Although congenital duplication can happen anywhere in the gastrointestinal tract, the ileum, oesophagus, and colon are the most common locations. The foregut, which includes the stomach, and first and second segments of the duodenum, is the source of one-third of all duplications. When foregut duplication involves the bronchial tree, respiratory symptoms are often present. Furthermore, excision through surgery is required for pathological examination of the resected specimen for definitive diagnosis. The most promising surgical approach for cyst excision has been thought to be open surgical resection through a posterolateral thoracotomy incision. However, video assisted thoracoscopy surgery has recently emerged as a viable surgical option for duplication cyst removal In paediatric surgery, video assisted thoracoscopy surgery has been established to facilitate the removal of mediastinal masses. However there is a limitation of research in the literature regarding the best surgical technique for oesophageal duplication cyst excision. In girls, foregut duplication is more common, especially in cases when bronchopulmonary involvement is present. While many duplications result in issues in early development, some are discovered by accident. When foregut duplication involves the bronchial tree, respiratory symptoms are often present. Haemoptysis and respiratory distress may be present in specific cases of the patient. Here, we described a 5-year-old male infant's case of foregut duplication with bronchial involvement and its management

Nickel(II) complex based on bis-(1-(pyridin-2-yl-methyl)-benzimidazol-2-yl-methyl) ether and its utilization in the oxidation of 2-amino-4-tert-butylphenol

A mononuclear nickel(II) complex [Ni(L)2].(NO3)2.H2O is synthesized utilizing a bis-benzimidazolyl ligand (L = bis-(1-(pyridin-2-yl-methyl)-benzimidazol-2-yl-methyl)ether) and characterized by single-crystal X-ray diffraction, elemental analysis, UV-vis and IR spectroscopy. Ni(II) complex crystallizes in the tetragonal system with space group I41/a and appears to be propeller-shaped when viewed along the c-axis. The [Ni(L)2].(NO3)2 complex has been utilized for the oxidation for 2-amino-4-tert-butylphenol to 4-tert-butyl-o-benzoquinone in the presence of hydrogen peroxide and the average rate of reaction is calculated to be 63×10–7 M min–1. The presence of externally added acetate ion tends to inhibit the rate of reaction

Intra-operative point-of-procedure delineation of oral cancer margins using optical coherence tomography.

ObjectivesSurgical margin status is a significant determinant of treatment outcome in oral cancer. Negative surgical margins can decrease the loco-regional recurrence by five-fold. The current standard of care of intraoperative clinical examination supplemented by histological frozen section, can result in a risk of positive margins from 5 to 17 percent. In this study, we attempted to assess the utility of intraoperative optical coherence tomography (OCT) imaging with automated diagnostic algorithm to improve on the current method of clinical evaluation of surgical margin in oral cancer.Materials and methodsWe have used a modified handheld OCT device with automated algorithm based diagnostic platform for imaging. Intraoperatively, images of 125 sites were captured from multiple zones around the tumor of oral cancer patients (n = 14) and compared with the clinical and pathologic diagnosis.ResultsOCT showed sensitivity and specificity of 100%, equivalent to histological diagnosis (kappa, ĸ = 0.922), in detection of malignancy within tumor and tumor margin areas. In comparison, for dysplastic lesions, OCT-based detection showed a sensitivity of 92.5% and specificity of 68.8% and a moderate concordance with histopathology diagnosis (ĸ = 0.59). Additionally, the OCT scores could significantly differentiate squamous cell carcinoma (SCC) from dysplastic lesions (mild/moderate/severe; p ≤ 0.005) as well as the latter from the non-dysplastic lesions (p ≤ 0.05).ConclusionThe current challenges associated with clinical examination-based margin assessment could be improved with intra-operative OCT imaging. OCT is capable of identifying microscopic tumor at the surgical margins and demonstrated the feasibility of mapping of field cancerization around the tumor

Efficacy of Manjistha and Ginger Powder in Extending the Lifespan of Drosophila melanogaster

Ageing is a condition of deterioration of the physiological functions necessary for survival and fertility over time. It is found to be due to cellular damage caused by reactive oxygen species produced during normal metabolism. Effect of manjistha and ginger were tested to see any effect on the lifespan of Drosophila melanogaster. Significant upsurge in the life span of flies reared on manjistha and ginger supplemented media was observed. These plant powders were observed to thwart the oxidative stress caused by paraquat, a potent herbicide and model neurotoxicant. Upon paraquat treatment, mortality rate of 12% and 8% was observed in male and female flies respectively that were reared on manjistha supplemented media whereas mortality of 100% and 92% were observed in male and female flies respectively when reared on control media. The present study suggests potential benefits on the longevity of the flies by the dietary supplementation with ginger and manjistha, especially in the oxidative stress condition. These findings should be further examined to identify active components in these plant products that show its manifestation on the well-being of the fly

Nickel(II) complex based on bis-(1-(pyridin-2-yl-methyl)-benzimidazol-2-yl-methyl) ether and its utilization in the oxidation of 2-amino-4-<i>tert</i>-butylphenol

36-42A mononuclear nickel(II) complex [Ni(L)2].(NO3)2.H2O is synthesized utilizing a bis-benzimidazolyl ligand (L = bis-(1-(pyridin-2-yl-methyl)-benzimidazol-2-yl-methyl)ether) and characterized by single-crystal X-ray diffraction, elemental analysis, UV-vis and IR spectroscopy. Ni(II) complex crystallizes in the tetragonal system with space group I41/a and appears to be propeller-shaped when viewed along the c-axis. The [Ni(L)2].(NO3)2 complex has been utilized for the oxidation for 2-amino-4-tert-butylphenol to 4-tert-butyl-o-benzoquinone in the presence of hydrogen peroxide and the average rate of reaction is calculated to be 63×10–7 M min–1. The presence of externally added acetate ion tends to inhibit the rate of reaction

Audio and image encryption scheme based on QR decomposition and random modulus decomposition in Fresnel domain

In this paper, an asymmetric audio and image encryption mechanism using QR decomposition and random modulus decomposition (RD) in the Fresnel domain is proposed. The audio file is recorded as a vector and converted to a two-dimensional array to act as an image or a sound map. This sound map is encrypted using the image encryption algorithm proposed in this paper. The proposed cryptosystem is validated for both audios and grayscale images. Fresnel parameters and the two private keys obtained from QR decomposition and random modulus decomposition (RD) form the key space. Computer-based reproductions have been carried out to prove the validity and authenticity of the scheme. Simulation results authenticate that the scheme is robust and efficient against various attacks and is sensitive to input parameters

Molecular docking and physicochemical studies of 1,3-benzodioxole tagged Dacarbazine derivatives as an anticancer agent

AbstractCancer, the biggest cause of death globally, remains a tough illness despite enormous advances in therapy. In the present study, 1,3-benzodioxole-tagged dacarbazine derivates were investigated as microtubule inhibitors in order to control cancer as microtubules are involved in cell proliferation. The tubulin protein was analyzed and its structure was validated by various protein validation tools. The binding potential of 1,3-benzodioxole-based dacarbazine-tagged derivatives with tubulin was checked using molecular docking software HEX 8.0 CUDA and AutoDock Vina. Swiss ADME online Web server and pkCSM are used for studying pharmacokinetic and pharmacological studies of compounds. The docking analysis ADME studies displayed that Compounds 1 and 2 bind effectively with the tubulin protein and showed potential properties to use as a potent anticancer drug